Pep Mogul

Covering peptides, longevity, and the future of medicine.

[Pep Mogul @pepmogul]

@ItsPeptime i think the most optimal stack would be:
- dermaroller
- minoxidil (topical)
- GHK-Cu/AHK-cu topical

[Superpower @superpower]

A study from 2025 estimated that 76% of future stomach cancers may be attributable to one bacterium in the stomach.

But unlike most cancer risks, this one actually can be treated: (1/16)

[Pep Mogul @pepmogul]

@morellifit what's the cost of the entire testing?

[Pep Mogul @pepmogul]

@velvetpunch @BasedBiohacker this is where i get bromantane, but it's for RUO only, not for human consumption.

regarding modafinil, it's a prescription drug

https://t.co/VzorJgcQEl

[Pep Mogul @pepmogul]

I'll leave an affiliate link to where I get this Russian smart drug if you want to check it out. It's currently at 50% off.

This isn't medical advice and the bromantane mentioned is for research use only. Always consult your doctor.
https://t.co/Obw60jgeXh

[Pep Mogul @pepmogul]

It's happening to porn too.

As GLP-1 use exploded, Pornhub traffic fell from roughly 2.45B monthly visits in 2023 to 1.7B by late 2024.

At the same time, semaglutide prescriptions were up 442% from 2021.

[Max Marchione @maxmarchione]

GLP-1s are eating the food industry.

After households start GLP-1s, grocery spending falls 5.3%, fast-food spending 8%, and savory snacks 10%.

Among high-income households, grocery spend drops 8.2%.

Big Food has a GLP-1 problem.

[Pep Mogul @pepmogul]

GLP-1s are the most disruptive drugs of this century.

[Max Marchione @maxmarchione]

GLP-1s are eating the food industry.

After households start GLP-1s, grocery spending falls 5.3%, fast-food spending 8%, and savory snacks 10%.

Among high-income households, grocery spend drops 8.2%.

Big Food has a GLP-1 problem.

[Pep Mogul @pepmogul]

@Inversarian @BasedBiohacker the only side effect i experienced was 1000% business growth this year

[Pep Mogul @pepmogul]

Good news if you’re a 20-month-old female mouse:

Semaglutide extended median lifespan by 12%

Not exactly human longevity proof yet, but still a pretty strong result.

[Lifespan @JoinLifespan]

New paper @Nature: Semaglutide recapitulates many of the benefits of caloric restriction in female mice & extends lifespan by almost 100 days. Males not yet tested for lifespan

Below: Red traces = mouse movement

[Pep Mogul @pepmogul]

@morellifit absolutely love it

[Pep Mogul @pepmogul]

I'll leave an affiliate link to where I get this Russian smart drug if you want to check it out. It's currently at 50% off.

This isn't medical advice and the bromantane mentioned is for research use only. Always consult your doctor.
https://t.co/Obw60jgeXh

[Pep Mogul @pepmogul]

Bromantane is probably the most desired nootropic when it comes to increasing motivation.

Motivation is everything.

Without motivation you don't get anything done, you're not productive.

What's said about bromantane is that you can ingest it once and experience good levels of motivation throughout the whole course of the day.

It's often described as an adaptogen, meaning a nootropic that can better help you handle stress and better help you tolerate stress.

Bromantane could be special because it could help you relieve stress and at the same time help to energize you and motivate you.

Some people do notice an acute benefit.

They take it, feel a little bit stimulated, feel slightly more energetic, and then a lot of people have noticed that it does have a cumulative build-up effect.

Meaning that when you continuously use bromantane, it will work better day by day.

It becomes more and more noticeable.

What I do like about bromantane when I look at the research and some of the anecdotes is that it seems to be very effective for anxiety.

Something definitely neat and worth pointing out is the fact that bromantane did result in mice having decreased levels of anxiety in multiple studies.

So maybe there is something to say about bromantane being able to improve motivation levels while at the same time decreasing anxiety levels.

And if you look at individuals with neurasthenia specifically, a condition characterized by fatigue, headache, mental weariness and insomnia, those are the individuals that notice bromantane working.

This was shown in a month-long study of over 700 people, where they found that it helped to reduce their symptoms and even helped them to improve their sleep.

Bromantane looks neat.

Improving motivation levels while at the same time decreasing anxiety levels is what makes it especially interesting.

[Michael Morelli @morellifit]

Bromantane may be a God-level nootropic.

I've been taking this Russian smart drug for months now.

It gives me this calm energy without jitters. It also feels as if it has permanently increased my motivation.

Here's the breakdown: (1/11)

[Pep Mogul @pepmogul]

When you actually read studies behind these popular functional medicine remedies like Berberine, you'll realize that most of it is just hype.

Nothing compares to good-old Big Pharma products and their effectiveness.

[Superpower @superpower]

Berberine is often called a “real-world GLP-1.”

But if you’re using it just to lose weight, you may be overlooking its stronger effects on blood sugar, insulin and cholesterol.

Here’s the breakdown: (1/15)

[Pep Mogul @pepmogul]

@maxmarchione validates my decision of throwing that overpriced whoop bracelet in trash

[Pep Mogul @pepmogul]

Normies can’t comprehend that elites are on advanced biohacking stacks hence why they’re running laps around you.

But they’ll still try to convince you the secret is affirmations.

[George Ferman @Helios_Movement]

JFK's stack is so wild.

He was on:
-Cytomel
-Ritalin
-Barbiturates
-Hydrocortisone
-Methyltestosterone
-Antispasmodics
-Procaine injections
-Stelazine
-Chlordiazepoxide
and much more.

[Pep Mogul @pepmogul]

Fascinating.

[Michael Morelli @morellifit]

Dogs may be the best way we have to understand human aging.

Researchers analyzed thousands of metabolites in dogs' blood and looked for patterns to whether they died earlier or lived longer.

Then they compared this with 5 large human mortality studies.

And guess what?

Many of the metabolic signals associated with longer/shorter lifespan in dogs looks similar to the ones they've seen in humans.

These metabolites can reflect things like metabolism, inflammation, how cells are responding to stress, etc.

Dogs also give researchers speed.

They live in the same homes we do and share our environment along with age-related diseases we get.

So instead of waiting for 70+ years to study an entire human lifespan, we can test ideas about aging in dogs who live around 12-13 years, and potentially extend their lifespan and healthspan.

This is what we're doing with ChooChoo who is right now the most measured dog on the planet.

We’re measuring:

- Gut microbiome
- Food intolerances
- Glyphosate exposure
- Heavy metals + minerals
- Mycotoxins
- Vitamin D
- Full in-home integrative assessment
- Personalized recommendations
- 40-minute results review

And this is only the beginning.

We wanna understand every measurable input into his health, track how it changes over time, and use that data to maximize both lifespan and healthspan.

This way, we can allow other dogs and their owners to do the same.

And the more we learn about extending healthy lifespan in dogs, the more we can learn about doing the same in humans.

[Michael Morelli @morellifit]

“Peptides probably don’t do that much.”

The peptides on day 100:

[Pep Mogul @pepmogul]

@morellifit 😂

[Pep Mogul @pepmogul]

In 10 years, dog longevity will be a category everyone talks about, and @morellifit will be the guy who started it.

[Michael Morelli @morellifit]

ChooChoo is 14 years old.

Before peptides, he couldn't walk or jump and limped every time he tried. We put him on BPC-157 and TB-500, and now he moves like a young dog.

He's the best peptide case study in my life.

Comment PAW and I'll send you his protocol.

[Pep Mogul @pepmogul]

@morellifit paw