Physician. Creator of Opus23. NYT best-selling author. Resuscitator of old VWs and mechanical watches. Expert knob-twiddler. Still codes in perl. #AI#ML.
New piece from our lab: alpha-Gal syndrome from a glycobiologist's perspective. How glycans in ticks' saliva immunize us, and how our immune system responds to similar glycans present in red meat.
https://t.co/dWWIF3NR97
@alphagal_info#glycotime
In silico transcriptome-based drug screening identifies celastrol as a multi-species therapeutic agent against aging-related sarcopenia and mitochondrial dysfunction
https://t.co/gfYuXWKSDJ
Is cellular rejuvenation the future of medicine? A groundbreaking clinical trial is set to test "partial reprogramming"—a method that dials back cell development to refresh aged tissues and organs. From restoring eyesight to rejuvenating the brain, the potential is massive. https://t.co/iUXbBxGxYP
#Longevity #Biotech #rejuvenation #Cells #Biology #CellularReprogramming #AntiAging #ScienceNews #Innovation #BrainResearch #epigenome
‘What truly stands out is the generosity of spirit and the breadth of curiosity on display. These are not academic essays aimed at impressing peers. They are piecemeal approximations of reality, offered by a man who has spent a lifetime paying attention across medicine, publishing, computation, systems theory, bioinformatics, and the arts. The result is a book that feels like a long, wise conversation with someone who has seen a great deal, thought deeply about it, and emerged with a perspective that is entirely his own. Each entry is short enough to be savored in a quiet moment, yet substantial enough to linger.
I believe Seeing Is Louder Than Words has strong appeal for readers of philosophical essays, reflective nonfiction, and anyone who enjoys the eclectic, erudite, and deeply human writing of Oliver Sacks, Lewis Thomas, or Nassim Nicholas Taleb. With its blend of personal history, professional insight, and quiet wisdom, the book is well-positioned to engage an audience seeking meaning, connection, and a fresh perspective on the ordinary elements of daily life. ‘
‘What truly stands out is the generosity of spirit and the breadth of curiosity on display. These are not academic essays aimed at impressing peers. They are piecemeal approximations of reality, offered by a man who has spent a lifetime paying attention across medicine, publishing, computation, systems theory, bioinformatics, and the arts. The result is a book that feels like a long, wise conversation with someone who has seen a great deal, thought deeply about it, and emerged with a perspective that is entirely his own. Each entry is short enough to be savored in a quiet moment, yet substantial enough to linger.
https://t.co/wohaq95Ttf
Conjecture Institute Advisor @yudapearl on the three levels of reasoning:
Lowest level: statistics (correlations between events)
Middle level: action (the world of intervention, randomized experiments)
Highest level: counterfactual, understanding, retrospection, explanation, imagination
Huge congratulations to the incredible @23andMeResearch Team for getting this over the finish line. And as always, a huge thank you to the @23andMe participants who made all this research possible! Check out the full paper here:
https://t.co/z3AhJ28mId
The Library of Alexandria was never destroyed in a single fire. The real story is even more tragic.
Everybody knows the story: fanatics burned down the Library of Alexandria, and centuries of the world's knowledge was lost in a night, never to be recovered.
The problem? None of it holds up. There were disasters, certainly, but the Library either survived or was rebuilt. After Caesar's famous accidental fire during his civil war in 48 BC, for example, the geographer Strabo documents visiting the site. We hear that a Christian mob destroyed a library in 391 AD, and a famous story has Caliph Omar ordering the scrolls burned as bathhouse fuel during the Islamic conquest of 642 AD — but the first wasn't the main Library, and the second is little more than myth.
The real story is slower and harder to dramatise: funding cut, stipends abolished, foreign scholars expelled, papyrus scrolls left to crumble. The scholarly community had probably ceased by the 260s AD.
The dramatic version persists because it's a better story. The real version (a great institution quietly defunded and neglected) is less cinematic. It's also considerably more familiar.