Petar Kanev

@LGS_IMB

[Radoslav Aleksandrov @radaleksandrov]

Hey there, PARP1 and DNA repair enthusiasts!
Check out our very (!) detailed and recently published “Protocol for quantifying PARP inhibitor-induced changes in PARP1 dynamics and activity through live-cell imaging” @STARProtocols
https://t.co/LhsyY6dhT0

👇A short thread!

[Laboratory of Genomic Stability @LGS_IMB]

Have you ever wanted to track individual #chromosomes during #mitosis? To do live cell #karyotyping and map the inter- and intra-chromosomal contacts dynamics? Our recent work made that possible. Check out our @NatureCellBio paper:
https://t.co/w6iaGC8a6n

[Petar Kanev @petkanev]

@holland_tom styles make fights

[Laboratory of Genomic Stability @LGS_IMB]

https://t.co/pdJlbc6sjs We are glad to see further evidence confirming our finding that loop extrusion is dispensible for the spread of gH2AX (doi: 10.1016/j.isci.2024.110826). #loopextrusion #cohesin #dnarepair #DDR #DSB

[Zha Lab @zha_lab]

Happy New Year from Social DNAing to you all! Let us roll with 2025!

[Petar Kanev @petkanev]

Contributing to efforts toward elucidating the response to replication stress, we provide a precise timescale of fork stalling and restart in live cells, at 30-s resolution (airyscan teaser below). https://t.co/cvLW0YaI5O
#replicationstress #DNArepair #ATR #replication #DNA #RPA

[Laboratory of Genomic Stability @LGS_IMB]

If you are curious whether loop extrusion is required for γH2AX spread and MDC1 recruitment, you can have a look at the most recently published work from our lab out now in iScience #dnarepair #ATM #MDC1 #γH2AX #DDR #loopextrusion #cohesin
https://t.co/os9tFT7Dvt

[Tom Holland @holland_tom]

“Grandiloquent, idle, useless, inactive & timid.”

Obituary of the Dauphin, Louis of Guyenne, following his death of dysentery in December 1415

[Radoslav Aleksandrov @radaleksandrov]

We are happy to share our latest paper “A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells”, out today in @CellReports. #PARP1 #PARPinhibitor #GenomicStability

Hopefully not a boring thread ↓

https://t.co/MCU6BsbJRQ

[Cell Reports @CellReports]

A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells https://t.co/2JOg06rdOh

[Euro-BioImaging ERIC @EuroBioImaging]

Interested in protein dynamics and #DNArepair? Why not work with the experts at Sofia BioImaging Node? The Node has 2 new instruments for Fluorescence-lifetime imaging microscopy (#FLIM) - and #funding for Bulgarian researchers. Learn more ⤵️
https://t.co/DEKmsXjodr