pharmacy by asim

💊 Love to break down complex medical and pharmacology concepts in simple words. 🎯 Follow us to remain updated with knowledge of medicine & health biology.

[pharmacy by asim @pharmed0929]

🎯Embark on a journey towards becoming a knowledgeable and skilled pharmacy professional with our comprehensive online pharmacy course.

📍You can register yourself by reaching us through:
🔸what's app: 00966570996069
🔸email: [email protected]
#pharmacy #medicine #courses

[pharmacy by asim @pharmed0929]

💊Hydroxyurea is an oral antimetabolite primarily used for:
- chronic myeloid leukemia (CML)
- sickle cell anemia &
- essential thrombocythemia
🦴reduce sickle cell crises by boosting fetal hemoglobin (HbF)
- Common side effects are myelosuppression, GI upset, and skin ulcers.

[pharmacy by asim @pharmed0929]

💊Tranexamic Acid (TXA) – Key Facts

- Competitive plasminogen inhibitor → prevents fibrin clot breakdown (antifibrinolytic)
- Used in Postpartum hemorrhage, Heavy menstrual bleeding & Hereditary angioedema
- Thromboembolism risk (use cautiously in DVT/PE history)

[pharmacy by asim @pharmed0929]

💊 Nebivolol's Unique Features 💊

- β₁-Selective with vasodilatory effect
- Neutral effects on glucose/lipids
- May improve endothelial dysfunction

📍 Combines β₁-blockade + NO-mediated vasodilation → preferred in HTN, especially in metabolic syndrome.

#MedTwitter #MedEd

[pharmacy by asim @pharmed0929]

💊 Ethambutol is known to cause optic neuritis (leading to blurred vision, color blindness, or vision loss) as a dose-dependent side effect.

💊 Patients on ethambutol should undergo baseline and periodic vision monitoring.

#Pharmacology #MedEd #USMLE #MedTwitter #Ethambutol

[pharmacy by asim @pharmed0929]

@Info_pharmacy ⚠️ Clarithromycin (a CYP3A4 inhibitor) significantly increases simvastatin levels → high risk of myopathy/rhabdomyolysis.

🚫 Avoid Combination:
Simvastatin doses >20 mg/day are contraindicated with clarithromycin.

[pharmacy by asim @pharmed0929]

🎯Levofloxacin injection should be administered for adult and pediatric patients by slow IV infusion over 60 minutes (250 to 500 mg) and over 90 minutes (for 750 mg).

🚨 Due to an increased RISK of HYPOTENSION, bolus or rapid IV administration should be avoided.

[pharmacy by asim @pharmed0929]

🎯 PPIs may diminish the therapeutic effect of CLOPIDOGREL, do not use OMEPrazole and ESOMEPrazole while taking clopidogrel.

🪀 inhibit enzyme CYP2C19 ---> converts clopidogrel into active form (antiplatelet effect).

🧊 RABEprazole or PANToprazole have less risk.

[pharmacy by asim @pharmed0929]

💊 CaptoPRIL Clinical Pearls 💊

- ACE-inhibitor drug
- angioedema (rare side effect)
- short half-life (2 hours) & typically requires dosing 2–3 times daily
- cause hyperkalemia
- teratogenic : avoid in pregnancy
- used in captopril renal scans

#captopril #HTN #clinicalpearl

[pharmacy by asim @pharmed0929]

💊 𝗡𝗶𝗮𝗰𝗶𝗻’𝘀 𝗜𝗺𝗽𝗮𝗰𝘁 𝗼𝗻 𝗟𝗶𝗽𝗶𝗱𝘀 💊
✅ Niacin + HMG-CoA Reductase Inhibitors (Statins) → ⬇️ LDL (additive effect)

✅ Niacin + Omega-3 Fatty Acids → ⬇️ Triglycerides (synergistic reduction)

✅ Niacin Alone → ⬆️ HDL (best pharmacologic HDL booster)

[pharmacy by asim @pharmed0929]

🍩 PPIs are acid-activated prodrugs metabolized by CYP2C19.
🪀 Metabolic variations affect efficacy: Asians & the elderly often have higher BA, requiring lower doses.
👀 Understanding their metabolism helps tailor dosing for optimal effectiveness across different populations.

[pharmacy by asim @pharmed0929]

💊 Amiodarone high iodine content disrupts thyroid function, cause hypo or hyperthyroidism.

🕯️ It also blocks T4→T3 conversion & has direct thyroid cell toxicity. Due to long half-life, thyroid dysfunction can develop months after starting therapy.

🧿 Monitor TSH regularly.

[pharmacy by asim @pharmed0929]

💊 DOXYCYCLINE is the only tetracycline antibiotic that can be safely used in patients with kidney failure because it is primarily EXCRETED via the gastrointestinal tract" (not the kidneys).

#tetracycline #antibiotics #pharmacology #ClinicalPearl

[pharmacy by asim @pharmed0929]

💡 Prednisolone Dispersible Tablet Advantages 💡

✅Dispersible prednisolone tablets dissolve quickly in water/saliva, offering:
- Faster absorption
- Easier administration

✅ Clinical Uses:
- Acute asthma attacks
- Chemotherapy-induced nausea
- Post-surgical inflammation

[pharmacy by asim @pharmed0929]

⚠️ Combining prednisolone & fluoroquinolones raises risk of tendonitis/rupture, especially in elderly, renal-impaired, or physically active patients.

💡 Corticosteroids amplify fluoroquinolone-induced collagen damage in tendons. Monitor for tendon pain/swelling during use.

[pharmacy by asim @pharmed0929]

🚨 Main patient counseling points for (SIiver Sulfadiazine) FLAMAZINE CREAM:

- discard cream after 7 days of opening
- don't use in pregnant and neonates
- may cause leukopenia on long term use
- only use for deep wounds not for superficial wounds

[pharmacy by asim @pharmed0929]

@nouf_almsabi هل يمكنك من فضلك أن تخبرني - كيف يمكننا التسجيل في هذه الدورة - شكرًا

[pharmacy by asim @pharmed0929]

🔎A 22-year-old traveler from "SOUTH ASIA" presents with fever, headache, and rose spots. Blood cultures grow SALMONELLA Typhi.

🎯 What is the FIRST-LINE antibiotic in areas without resistance?

#typhoid #salmonella #pharmacology #MedQuiz #ClinicalPearsl

[pharmacy by asim @pharmed0929]

💎 𝗣𝗶𝗼𝗴𝗹𝗶𝘁𝗮𝘇𝗼𝗻𝗲 𝗖𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗣𝗲𝗮𝗿𝗹𝘀💎

💊Pioglitazone belongs to 𝙏𝙝𝙞𝙖𝙯𝙤𝙡𝙞𝙙𝙞𝙣𝙚𝙙𝙞𝙤𝙣𝙚𝙨 (𝙏𝙕𝘿) 𝙘𝙡𝙖𝙨𝙨 is a PPAR-γ agonist, which 𝙚𝙣𝙝𝙖𝙣𝙘𝙚𝙨 𝙞𝙣𝙨𝙪𝙡𝙞𝙣 𝙨𝙚𝙣𝙨𝙞𝙩𝙞𝙫𝙞𝙩𝙮 in peripheral tissues (muscle, adipose) and mildly reduces hepatic glucose output.

💊 𝙎𝙩𝙖𝙣𝙙𝙖𝙧𝙙 𝙨𝙩𝙖𝙧𝙩𝙞𝙣𝙜 𝙙𝙤𝙨𝙚 is 15–30 mg once daily, with a maximum of 45 mg/day, adjusted based on response and tolerability.

💊 TZDs like pioglitazone are particularly 𝙚𝙛𝙛𝙚𝙘𝙩𝙞𝙫𝙚 𝙞𝙣 𝙞𝙣𝙨𝙪𝙡𝙞𝙣-𝙧𝙚𝙨𝙞𝙨𝙩𝙖𝙣𝙩 𝙥𝙖𝙩𝙞𝙚𝙣𝙩𝙨, especially those who are overweight or obese.

💊 Pioglitazone has 𝙛𝙖𝙫𝙤𝙧𝙖𝙗𝙡𝙚 𝙚𝙛𝙛𝙚𝙘𝙩𝙨 𝙤𝙣 𝙡𝙞𝙥𝙞𝙙𝙨: it can raise HDL, may reduce triglycerides, and does not significantly increase LDL like rosiglitazone.

💊 Pioglitazone causes fluid retention and is 𝙘𝙤𝙣𝙩𝙧𝙖𝙞𝙣𝙙𝙞𝙘𝙖𝙩𝙚𝙙 𝙞𝙣 𝙉𝙔𝙃𝘼 𝘾𝙡𝙖𝙨𝙨 𝙄𝙄𝙄/𝙄𝙑 𝙝𝙚𝙖𝙧𝙩 𝙛𝙖𝙞𝙡𝙪𝙧𝙚 due to risk of worsening edema and pulmonary congestion.

💊 Long-term use of TZDs is 𝙖𝙨𝙨𝙤𝙘𝙞𝙖𝙩𝙚𝙙 𝙬𝙞𝙩𝙝 𝙞𝙣𝙘𝙧𝙚𝙖𝙨𝙚𝙙 𝙛𝙧𝙖𝙘𝙩𝙪𝙧𝙚 𝙧𝙞𝙨𝙠, particularly in postmenopausal women, due to decreased bone mineral density.

🎳 𝗝𝗼𝗶𝗻 𝘂𝘀 𝗮𝘁 𝗪𝗵𝗮𝘁𝘀𝗔𝗽𝗽: https://t.co/Ul8bLZNmls

#diabetes #heartfailure #pharmacology #pharmacist #clinicalpearls

[pharmacy by asim @pharmed0929]

This patient presents with typical symptoms of uncomplicated cystitis (burning urination and frequency) in a young, non-pregnant woman with no systemic signs (e.g., fever, flank pain, nausea/vomiting), ruling out pyelonephritis.

In uncomplicated cystitis, always choose agents with narrowest spectrum, least collateral damage, and good urinary tract penetration—Nitrofurantoin fits this profile best.

[pharmacy by asim @pharmed0929]

💎 𝗛𝗲𝗺𝗼𝗿𝗿𝗵𝗼𝗶𝗱𝘀 (𝗣𝗶𝗹𝗲𝘀) 𝗖𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗣𝗲𝗮𝗿𝗹𝘀 💎

📍 Piles = 𝗛𝗲𝗺𝗼𝗿𝗿𝗵𝗼𝗶𝗱𝘀 → swollen rectal veins, internal or external.

📍𝗧𝘆𝗽𝗲𝘀: internal hemorrhoids and external hemorrhoids.

🔢 𝗚𝗿𝗮𝗱𝗶𝗻𝗴 𝗼𝗳 𝗶𝗻𝘁𝗲𝗿𝗻𝗮𝗹 𝗵𝗲𝗺𝗼𝗿𝗿𝗵𝗼𝗶𝗱𝘀:
Grade I: Bleeding, no prolapse.
Grade II: Prolapse on straining, spontaneously reduce.
Grade III: Prolapse, require manual reduction.
Grade IV: Irreducible prolapse, possible thrombosis.

💊 𝗗𝗮𝗳𝗹𝗼𝗻 (MPFF – diosmin + hesperidin): 1000 mg/day for chronic cases, higher for acute.

🧴 𝗧𝗼𝗽𝗶𝗰𝗮𝗹 𝗮𝗴𝗲𝗻𝘁𝘀:
Lidocaine: Local anesthetic
Hydrocortisone: Anti-inflammatory
Phenylephrine: Vasoconstrictor

🥗 𝗟𝗶𝗳𝗲𝘀𝘁𝘆𝗹𝗲 𝗶𝗻𝘁𝗲𝗿𝘃𝗲𝗻𝘁𝗶𝗼𝗻𝘀: High-fiber diet, hydration, stool softeners, avoid straining.

🩺 𝗦𝘂𝗿𝗴𝗶𝗰𝗮𝗹 𝗼𝗽𝘁𝗶𝗼𝗻𝘀 𝗳𝗼𝗿 𝗚𝗿𝗮𝗱𝗲𝘀 𝗜𝗜𝗜–𝗜𝗩: Rubber band ligation, sclerotherapy, or hemorrhoidectomy.

🔎 𝙔𝙤𝙪 𝙘𝙖𝙣 𝙖𝙡𝙨𝙤 𝙘𝙝𝙚𝙘𝙠 𝙤𝙪𝙩 𝙢𝙮 𝙙𝙚𝙩𝙖𝙞𝙡𝙚𝙙 𝙫𝙞𝙙𝙚𝙤 𝙖𝙗𝙤𝙪𝙩 "𝙃𝙀𝙈𝙊𝙍𝙍𝙃𝙊𝙄𝘿𝙎 𝙏𝙔𝙋𝙀𝙎, 𝙎𝙔𝙈𝙋𝙏𝙊𝙈𝙎 𝙖𝙣𝙙 𝙏𝙍𝙀𝘼𝙏𝙈𝙀𝙉𝙏" : https://t.co/vhsixKDAah

#HemorrhoidsCare #pilescare #PharmacistLife #clinicalpearls #youtubevideo #PharmacologyNursing #physiologyfacts #pharmacylectures #nursinglectures
#MedTwitter