PlumeX Assets

one with plumenetwork

[Irina Dudanova @IrinaDudanova]

Our joint study with Takaki Komiyama @takaki_komiyama is out in @Nature !
https://t.co/bW0tvl9cao

We found cell type-specific changes in the cortical circuit of Huntington’s disease mice. Optogenetic stimulation of VIP cells rescued circuit defects and improved motor function.

[UCSD BioSciences @ucsdbiosciences]

New in @Nature: Many details behind Huntington’s disease are unclear. UC San Diego researchers have now identified neurons in the disease’s progression. Using a light-based technique, they improved the disease's debilitating deficits. https://t.co/awdG2IIXSj

[Genetic Engineering & Biotechnology News @GENbio]

In Huntington’s Mouse, Optogenetic Activation of VIP Neurons Restores Brain Function

Researchers identified VIP inhibitory #neurons in Huntington’s disease and used #optogenetics to restore motor neuron activity in mice

@takaki_komiyama, @IrinaDudanova
https://t.co/6I0xESHQNz

[PlumeX Assets @plumex_assests]

This is my first study on a disease model. Personally satisfying as it builds on our many years of work on basic neurobiology of learning and applies it for a potential disease treatment.

[PlumeX Assets @plumex_assests]

Our new paper is out in Nature, congrats to Sonja et al.! An excellent collab with Irina Dudanova's group.

We promoted neuroplasticity to improve behavior in a mouse model of a neurodegenerative disease.

https://t.co/9gkIs93VXs

[PlumeX Assets @plumex_assests]

We found that changes in primary motor cortex are required for the learning of consistent movement patterns, but not important for other aspects of the task learning, like learning to respond to a cue.

Congrats to Jake and the team! Jake will start his lab at Rutgers in 2027!

[PlumeX Assets @plumex_assests]

Our new paper is out in Current Biology!

We learn many things in parallel, and brain circuits are constantly rewiring across brain areas. It is notoriously difficult to understand which rewiring events are responsible for which type of learning.

https://t.co/af0CJNzHqx

[PlumeX Assets @plumex_assests]

@NateWBradford Cool!

[PlumeX Assets @plumex_assests]

We found that mice adjust their history-integration strategies, and identified adaptive reconfiguration of neural circuits in the retrosplenial cortex that match behavioral adaptation.

Great work by Eva and all co-authors!

[PlumeX Assets @plumex_assests]

Our new paper is out in Neuron!

https://t.co/FhP19Jg3du

How does the brain decide how much of the past to use when making decisions? In rapidly changing environments, recent experiences matter more; in stable environments, longer histories are useful.

[PlumeX Assets @plumex_assests]

Tell me that the world’s been spinning since the beginning and everything will be alright…

[PlumeX Assets @plumex_assests]

@AssafRamot Sometimes…

[PlumeX Assets @plumex_assests]

Our new work is out in Science Advances. We show that neural activity in the striatum reflects not just cortical inputs, but also often-underappreciated thalamic inputs.

https://t.co/ppLG7auidL

[PlumeX Assets @plumex_assests]

@KeikoUTorii Thank you!

[PlumeX Assets @plumex_assests]

@AssafRamot We miss you!

[PlumeX Assets @plumex_assests]

Come see me at my Special Lecture on cortical circuits for learned movements, Monday morning at 10:30AM. #Sfn2025

[The Kavli Foundation @KavliFoundation]

Will you be at #SfN25? Don’t miss these lectures in Ballroom 20:

📍Sun 11/16 3pm: The Neural Code of Speech (Edward Chang, KIFN)
📍Mon 11/17 10:30am: Motor Cortex Circuits for Learned Movements (Takaki Komiyama, KIBM)
📍Tue 11/18 5:30pm: Neuronal Aging & Cognitive Decline (Rusty Gage, KIBM)

#KavliNeuro

[PlumeX Assets @plumex_assests]

A mythical unicorn god on the baseball field

[Simons Foundation @SimonsFdn]

A new @Nature study from Simons Collaboration on the Global Brain investigator @takaki_komiyama finds that as mice learn a complex movement, the pathway from a deep brain region called the motor thalamus to the motor cortex rewires itself to drive the movement: https://t.co/UTSAa4OLMy #science #neuroscience