Pascal Maguin

Sr Scientist at Regeneron Pharmaceutical - Former PhD student in the @MarraffiniLab.

[Amer Azim Hossain @amer_hossai1]

Excited to share my latest work from the @MarraffiniLab, in collaboration with @PhoebeARice, now online @Nature!!

https://t.co/95cscM2MJr

We report the discovery of DNA glycosylases that provide anti-phage defense in bacteria!

A thread 🧵: 1/

[Pascal Maguin @pmaguin]

@graigu You’d better not kill the groove

[Nora Pyenson @norapyenson]

Can the simplest living things coexist 🏘️ in the face of competition?

We found that bacterial viruses (phages) could easily form diverse communities, even though they shared the same resource 🍝 (an isogenic host population) (1/7)
https://t.co/FexjXLVPUH

[alex meeske @alexjmeeske]

Pleased to present the final version of work showing how RM systems resolve the type VI CRISPR immune response. We’re very proud of Maddie and Lexi’s efforts and hope it spurs more investigations of defense systems working in concert with each other

[Andrew Varble @andrewjvarble]

I’m happy to announce that I’m bringing my miniprep skills to the University of Rochester to start my own lab focused on CRISPR, HGT, and recombinases. This is where people usually say interested postdocs, students, RAs contact me, not going to rock the boat, so same! @UofR

[Jakob T Rostøl @jakob_tr]

when you say one bacteria instead of one bacterium

[Pascal Maguin @pmaguin]

@jakob_tr @MarraffiniLab Awww merci!

[Pascal Maguin @pmaguin]

@AudeBer @MarraffiniLab Merci Aude!

[Jakob T Rostøl @jakob_tr]

Me: I need to do more reading to bolster my knowledge and improve as a scientist

The reading:

[Andrew Varble @andrewjvarble]

My CRISPR-integrating phage paper is out! https://t.co/oUvi2KKW03

Thanks everyone, especially ΦAP1.1, who without it's dedication this would have been impossible.

[Nature Microbiology @NatureMicrobiol]

OUT NOW: Prophage integration into CRISPR loci enables evasion of antiviral immunity in Streptococcus pyogenes

A work by Marraffini & co @MarraffiniLab @andrewjvarble @RockefellerUniv

read it here: https://t.co/2iGUdA99G3

https://t.co/jM0yPa7iLH

[Amanda Shilton @AKShilton]

Congrats on your well deserved induction into the American Academy of Arts and Sciences @MarraffiniLab! We’re all proud to be in your lab!

[Jakob T Rostøl @jakob_tr]

Delighted to finally share our most recent story on the type III CRISPR accessory nuclease Card1!🎉 More bacterial (CRISPR) immunity through non-specific catalytic activities… Fun collaboration with the Patel lab at MSKCC.
https://t.co/aO4ud6H6i0
A quick summary🧵:

[Pascal Maguin @pmaguin]

Congrats @reworkman0 and @jwmodell !! Great story!

[Rachael Workman @reworkman0]

Excited to share my first first-author paper from my PhD in the @jwmodell lab, out in @CellCellPress today!! Read about how we discovered bacteria evolved their very own CRISPRi sgRNAs to control their native CRISPR-Cas systems, story thread below (https://t.co/YMPYfOTimd)

[Pascal Maguin @pmaguin]

Congra-

[Pascal Maguin @pmaguin]

👏🏻👏🏻

[alex meeske @alexjmeeske]

I'm starting my lab at the @UW Dept of Microbiology next month - so excited to be joining a fantastic group of scientists and exploring CRISPR and phages on the west coast! Check out https://t.co/6jlqw1Q8JE for positions and more info

[Pascal Maguin @pmaguin]

🥳

[Kamala Harris @KamalaHarris]

We did it, @JoeBiden.

[Jakob T Rostøl @jakob_tr]

Jacques Monod and Francois Jacob, discussing the intricacies of the lac operon (Paris, early 1961)

[Jakob T Rostøl @jakob_tr]

Actually, it's only called CRISPR if it comes from the CRISPR region in France. Otherwise, it's called sparkling RNA-guided nucleases