Vladimir Kubyshkin

Physical organic chemistry, fluorine, amino acids, peptides and more
currently at Enamine Ltd, Ukraine

[Vladimir Kubyshkin @polyproline]

Application of phosphonoproline in peptidomimetic design. Mind the chirality of the phosphorus center!
https://t.co/wbngnCcbo1

[Vladimir Kubyshkin @polyproline]

This is a really pretty review on SCF3 chemistry focusing on amino acids and peptides. By Thierry, Greg and the team
https://t.co/so2SmYQWz4

[Vladimir Kubyshkin @polyproline]

And then the second one by a mixed group from China, who summarize a large massive of information on proline and its derivatives published between 2020-2025 in the medicinal chemistry context:
https://t.co/9dCkwLbiGv

[Vladimir Kubyshkin @polyproline]

For the record, it is really important to mention two really deep review articles published earlier this year about the application of proline analogues in medicinal chemistry. First one written by the living legends, Hanessian and Meanwell:
https://t.co/aHxE1B3Tjy

[Vladimir Kubyshkin @polyproline]

There is a pretty cool recent publication that introduces bridgehead substituted [2]ladderanes as ortho-aromatic bioisosteres. Practical synthesis, structural analysis, and bioactivity validation.
https://t.co/2kBwgqEFCI

[Vladimir Kubyshkin @polyproline]

Proline-rich antimicrobial peptides are still out there combating some nasty pathogens:

https://t.co/6WIeACPAuv

[Vladimir Kubyshkin @polyproline]

Selective targeting of the key enzyme in proline biosynthesis:
https://t.co/Y9txCLnCqA

[Vladimir Kubyshkin @polyproline]

Well, this is interesting set of data. The effect of azetidine-2-carboxylic acid exposure on neuroblastoma cells.
https://t.co/k6yXR8877S

[Vladimir Kubyshkin @polyproline]

Did you know that in chemistry you can ride bicycles? Very small. Really tiny. Yet, they can take you places you've never thought before.

Discover what these bicycles can do to bring us close to novel drugs in our recent review with @MykhailiukChem

https://t.co/bKb1PUl7dX

[Vladimir Kubyshkin @polyproline]

What a sad message 😟 this used to be such a useful resource. Thank you, molinspiration team!

[Vladimir Kubyshkin @polyproline]

Production of xenoproteins on a gram scale. The incorporated noncanonicals include fluoroprolines.
Looks pretty cool to me! 👍🏾
https://t.co/rVWiQ2uDjJ

[Vladimir Kubyshkin @polyproline]

@TheRubiniGroup sincere congratulations! 🥂

[Vladimir Kubyshkin @polyproline]

Very much enjoyed reading the newest review from Ned, Hamid and Huy on genetic code engineering. A summary of efforts, pitfalls and challenges.

https://t.co/txKhtiiZqx

[Vladimir Kubyshkin @polyproline]

Really impressive review article on how to improve substance's solubility AND permeability at the same time, the trait combination that the authors called Aufheben. Great summary of strategies and examples from contemporary drug design! Open access

https://t.co/G7fJhwJjRL

[Vladimir Kubyshkin @polyproline]

Just learned that chronic Staph. aureus readjusts its metabolism to feed on proline from collagen deposits. Mindblowing!

https://t.co/NDxqk07FPl

[Vladimir Kubyshkin @polyproline]

A whole panel of 5-spirocyclic proline analogues prepared by colleagues from Enamine
https://t.co/hZtvlRbGjT

[Vladimir Kubyshkin @polyproline]

Another amazing work from the group of JC Horng, unveiling the effects of cation-pi interactions in the assembly of the collagen triplex
https://t.co/foVnEXVwEZ

[Vladimir Kubyshkin @polyproline]

A fold stabilizing effect of a proline analogue on a 36 residues miniprotein
https://t.co/pBSXAdnGZB

[Vladimir Kubyshkin @polyproline]

Few interesting heteroatomic proline analogues in collagen mimetics. Seems that 5-oxaproline is well tolerated and accelerates the triple helical assembly. Great work!
https://t.co/KzUaMNRSj3

[Vladimir Kubyshkin @polyproline]

Aromatic caps at the termini promote stability to triple helix in collagen mimics with just 4-6 GPO repeats
https://t.co/PLamFCfGXr