Sarah Mackenzie-Dyck

[Sarah Mackenzie-Dyck @prairiegirrl]

Amazing! One woman, three autoimmune diseases: CAR-T therapy vanquishes ultra-rare disease trio https://t.co/HOEBTLLjwt

[Sarah Mackenzie-Dyck @prairiegirrl]

Cool! Succinate drives macrophage inflammation by promoting GPR91 mitochondrial signaling in rheumatoid arthritis | Science Translational Medicine https://t.co/F9nZBvLpbH

[Manuel Ruiz @manruipa]

🔴 I think it is time to start taking seriously the disease model we have been proposing for Long COVID and ME/CFS.
For years, we have argued that persistent viral reservoirs may be the initiating event connecting many of the mechanisms observed in these diseases:

-Chronic antigenic stimulation.
-Immune hyperactivation.
-T-cell exhaustion.
-Reactivation of latent herpesviruses.
-Chronic inflammation.
-Loss of immune tolerance.
-Autoimmunity in genetically susceptible individuals.

A new study has now identified the kind of cellular response that this model predicts:
Persistent, virus-specific, cytolytic and exhausted CD8⁺ T cells directed not only against SARS-CoV-2, but also against EBV and CMV.

This is not simply “an immune system that forgot to switch itself off.”
These lymphocytes recognize viral antigens.
The more important question is:
What continues stimulating them?

(1/13)🧵

[Sarah Mackenzie-Dyck @prairiegirrl]

Want to get more from AI? Treat every prompt like an experiment https://t.co/IlD89Oks9v

[Sarah Mackenzie-Dyck @prairiegirrl]

$25 million project will hunt for ‘self’ antibodies that alter cancer risk | Science | AAAS https://t.co/onIt3cKk50

[Sarah Mackenzie-Dyck @prairiegirrl]

This’ll be awesome! Because of course, Cats! 🐈‍⬛ 😀🐾

[Ricky Gervais @rickygervais]

25 years after my breakthrough show, I’m bringing out another one. ALLEY CATS drops next month on Netflix. It’s quite different to The Office. But it is a sitcom. Just with cats. 🐈‍⬛

[Dr. Sean Mullen @drseanmullen]

In 2020, my concern was infection and death.

By early 2021, after reading everything I could get my hands on, talking with infected individuals, and seeing changes emerge in cognitive screenings from my own lab, I realized we were dealing with something much bigger.

I’d tell my students, almost matter-of-factly, “Covid causes brain damage.” They’d look at me like I was Tom Hanks having a conversation with Wilson in Cast Away.

Years later, what’s hardest isn’t being right. It’s realizing how much of this could have been prevented…and how many people never had the chance.

[Sarah Mackenzie-Dyck @prairiegirrl]

I want to see a prison-to-PhD pipeline https://t.co/HATM0v9Gsz

[Sarah Mackenzie-Dyck @prairiegirrl]

“Quantum Just Killed the Trillion-Dollar Data Center Bet” by iswarya writes https://t.co/L17wj5ct9t

[Sarah Mackenzie-Dyck @prairiegirrl]

Spare a few bucks for a lovely cause 💜🐾

[Niall Harbison @NiallHarbison]

If you like the dogs I share and they cheer you up daily, I’d love you to watch this one video.

I only do this once a year and never ask any other time.

You can support here and if you can’t sharing this video helps 🙏 https://t.co/Roftrb3ZWW

[Sarah Mackenzie-Dyck @prairiegirrl]

At last, a pill that can prevent COVID after exposure to infected people https://t.co/EvxCKSfou2

[LongevityLab @LxngevityLab]

2 of the world's top cancer researchers just exposed everything wrong with how we treat cancer today.

Here are 7 lessons that could save your life (or someone you love):

1. Learn about the most underused free cancer "drug" in the world (in just 40 seconds):

[Valerie Anne Smith @ValerieAnne1970]

IVERMECTIN: FULL DOSAGE SCHEDULE FOR CANCER & PREVENTION

1000s of people use Dr. William Makis MD’s IVERMECTIN dosing chart. Here’s a clear, categorized breakdown based on body weight (mg/kg per day).

LOW DOSE: ≤ 0.5 mg/kg/day
**Best for:**
- Cancers in remission
- Strong family history or genetic predisposition
- Prophylaxis (preventive)
**Side effects:** No long-term side effects reported.
**Example:** Dr. Tess Lawrie reported a Stage 3 ovarian cancer case treated with chemo + 12 mg ivermectin daily. Tumor marker CA125 dropped from 288 to 22 after 2 months and the tumor vanished.

MEDIUM DOSE: 1.0 mg/kg/day
**Best for:** Starting dose for **most cancers** (lung, pancreatic, renal cell, gastric, etc.).
**Side effects:** No long-term side effects reported.
**Example:** Dr. Shankara Chetty’s 70-year-old prostate cancer patient (PSA 89) took 45 mg/day (plus lactoferrin). After two months PSA fell to 10.9.

HIGH DOSE: 2.0 mg/kg/day
**Best for:** Very aggressive cancers (leukemia, pancreatic, brain cancers).
**Side effects:** No long-term side effects reported.
**Example:** Dr. Allan Landrito’s Stage 4 gallbladder cancer patient took 2 mg/kg daily for 14 months — cancer disappeared.

VERY HIGH DOSE: ≥ 2.5 mg/kg/day
**Best for:** Extensive metastatic disease, extremely poor prognosis, or certain brain cancers.
**Side effects:** Possible short-term & transient visual effects (usually resolve in a few days).
**Example:** Dr. Shankara Chetty treated a patient with 2.5 mg/kg/day — no side effects reported.

**Quick conversion example (for a 60 kg / 132 lb person):**
- Low: ≤30 mg/day
- Medium: 60 mg/day (≈5×12 mg tablets or 1 teaspoon liquid)
- High: 120 mg/day
- Very High: ≥150 mg/day

Many anecdotal reports exist of long-term daily use (months to over a year) with no serious toxicity, but individual responses vary.

Always work with a knowledgeable clinician, especially if you have pre-existing conditions (e.g., vision issues or glaucoma). This is for educational purposes only.

Share to spread awareness — information is power. 💊

[Sarah Mackenzie-Dyck @prairiegirrl]

How Gut Bugs Use the Vagus Nerve as a Backdoor to the Brain https://t.co/zFA4DV7g8t

[Sarah Mackenzie-Dyck @prairiegirrl]

“What if we started thinking of mRNA-CRISPR gene editing the same way — as molecular surgery, not as a pharmaceutical product?” This May Be the Most Important Medical Story of the Decade https://t.co/UTFve6BIvT via @NYTOpinion

[Sarah Mackenzie-Dyck @prairiegirrl]

Neat!

[The Curious Tales @thecurioustales]

The science of fetal microchimerism should have broken the internet by now.

It hasn’t.

When I read about a research I was so curious to know what’s actually happening.

Fetal cells — carrying the child’s own DNA — cross into the mother’s bloodstream during pregnancy and never fully leave. They embed into her organs. Her heart muscle. Her brain tissue.

Researchers have found a child’s living cells inside mothers in their 90s, from pregnancies six decades old. The child left the womb. The cells didn’t.

And they don’t just sit there. They migrate toward damage. Women with heart injuries show fetal cells concentrated at the wound site. Women with thyroid disease show their children’s cells inside the affected tissue.

The body that built the child gets tended to, in return, by the child’s own cells. Nobody designed this consciously. Evolution quietly built a repair system out of the mother-child bond itself.

The brain side of this is equally staggering. Pregnancy triggers gray matter reorganization — a structural rewiring that sharpens threat detection, deepens empathy, fundamentally alters how a mother processes the world. These changes persist for years after birth.

Possibly permanently. A mother’s nervous system doesn’t return to its factory settings. It was updated by the experience of carrying another person, and that update sticks.

The part worth sitting with longest — women who experienced pregnancy loss carry fetal cells too. The cellular merging doesn’t require a birth. It doesn’t require years of raising someone. Those cells remain regardless of what happened after. A mother grieving a child she never brought home is grieving someone biologically still present inside her. The world consistently underestimates that grief. The science says we have no business doing that.

Mothers always knew the connection didn’t end at birth.

Turns out it doesn’t end at the cellular level either.

[Sarah Mackenzie-Dyck @prairiegirrl]

“This is the health documentary with real solutions...” https://t.co/uJEqqobG2x

[Sarah Mackenzie-Dyck @prairiegirrl]

America’s Rare-Earths Solution Is Hiding in Plain Sight https://t.co/WR5DTfMl34 via @NYTOpinion

[Sarah Mackenzie-Dyck @prairiegirrl]

Yipes! Brain cells birth zombielike transport vesicles | Science | AAAS https://t.co/oZG4zrNKDr

[Zdenek Vrozina @ZdenekVrozina]

Review paper.
At the center of Long COVID are three processes that reinforce each other -
persistent viral material, damage to the gut barrier, and chronic immune dysregulation. Together, they help explain why neurological and neuropsychiatric symptoms are so common and so persistent🧵