PREdiCCt

A #bigdata study looking to increase understanding of how #environment, lifestyle, #diet, genetics & the #microbiome influence flare in #Crohn's disease & #UC.

[Kate Low @covil_kate]

@VIPStudy1 Had your 3rd vaccine?😀. Please let your local site know 🙏🙏🙏

[CLARITY IBD @clarityibd]

Hey folks 👋
Do you want to know more about @clarityibd?

✅how/why it started? The latest results and what they mean?

Then do watch the talk by Dr Tariq Ahmad (@clarityibd very own 🎩🌟)

Annual General Meeting 2021 | Crohn's & Colitis UK https://t.co/cJIGxVsudr

[Charlie Lees @charlie_lees]

The environmental pressures on a modern gut are undoubtedly different from those of our hunter-gatherer ancestors. The microbiomes would reflect this.

What does this mean for us today?

The paleo vs plant-based debate shows this is complex.

More data would help!

[Charlie Lees @charlie_lees]

We now have clear guidance from JCVI on those patients eligible for a 3rd primary dose of COVID vaccine.

This includes IBD patients on infliximab, adalimumab, ustekinumab, tofacitinib, prednisolone and some on high-dose aza/mp/mtx.

Details here & below

https://t.co/aykyv766sJ

[Charlie Lees @charlie_lees]

The impact of Crohn's disease and UC on a person's life can be devastating.

With 1 in 125 of the population living with #IBD it is important we realise what they might be going through.

It isn't just physical; here 👇 are just some of the ways IBD affects people.

[PREdiCCt @predicct]

A reminder about our important study

TO ALL PARTICIPANTS:
- please log into the portal and complete a questionnaire today
- it doesn't matter how late it is
- late is definitely better than never

Thank you

[Kevin Whelan @ProfWhelan]

Meta-analysis of studies of nutrient intake in #InflammatoryBowelDisease #IBD #Crohns #Colitis

Low intake of fibre is strongest and most consistent finding

How can we help people with IBD to increase #fibre intake?

Full paper @HoldGeorgina @APandT 👉🏽 https://t.co/8G6s1ArbXn

[Charlie Lees @charlie_lees]

We are developing and testing increasingly targeted therapies for Crohn's disease & ulcerative colitis.

New molecules will hopefully bring increased efficacy with minimal / no safety issues.

Not all will make it to market - some have already failed.

But there is more to come.

[Charlie Lees @charlie_lees]

Prevention and cure are big words with a big impact.

But are they possible in IBD?

I've mapped out some of the key steps to move us to preventing IBD.

Data are coming ...

#ship30for30

[Charlie Lees @charlie_lees]

Day 13 of #ship30for30 paging all @predicct participants and requesting you complete the final follow-up questionnaire please
https://t.co/9FYN7NCjVk

[Charlie Lees @charlie_lees]

What happens when the delicate balance between environment, genes and microbiota is disrupted?

Inflammatory bowel disease (IBD) can develop

Crohn's disease and ulcerative colitis now affect 1 in 125 people in the developed world.

The numbers are going up fast elsewhere.

[Charlie Lees @charlie_lees]

I have a big favour to ask.

Have you taken part in the @PREdiCCt study? Then we need your help.

Please log into the PREdiCCt portal and complete the final questionniare.

Here is why this is so important and a big thank you.

@crohnscolitisUK @crohnscolitisc3

[Charlie Lees @charlie_lees]

Multiple environmental factors impact the gut in health and inflammatory bowel disease:

• diet
• sleep
• travel
• stress
• surgery
• hygiene
• exercise
• smoking
• geography
• emulsifiers
• medications

Important to take a HOLISTIC approach to health and disease.

[Charlie Lees @charlie_lees]

These data were presented as an e-poster at the DDW and ECCO meetings this year by our IBD clinical fellow turned consultant @SSiakavellas

Here is the full poster [👇]
@predicct @UoE_CGEM @LauranneDerikx

[Charlie Lees @charlie_lees]

What causes disease flares in IBD?

We asked the 2639 participants of the @PREdiCCt study in their baseline questionnaire.

1946 replied - these were their top responses
• stress (69.8%)
• dietary changes (46.8%)
• alcohol (19%)
• sleep disturbance (17%)

#ship30for30

[PREdiCCt @predicct]

Still open if you’ve had your 2nd vaccine in June or July. Please check it out #IBD

[Charlie Lees @charlie_lees]

We are now studying the affect of ustekinumab and tofacitinib and drug combinations in IBD as part of the @VIPStudy1
https://t.co/ity9kFq43x

[Charlie Lees @charlie_lees]

I've started to think about life for our patients post-pandemic.

We face many challenges but I'm optimistic.

Advances in drug development, genomics, digital health, AI & more.

This is the start of a new series on Innovations in IBD & the story of the innovators.
#ship30for30

[Charlie Lees @charlie_lees]

We asked 1946 patients with Crohn's and UC in remission about fatigue: here's what we found.

40% of patients were fatigued >50% of the time.

Factors associated with fatigue
• depression & anxiety
• clinical disease activity
• female sex and higher BMI

@PREdiCCt #Ship30for30

[Cure Crohn's Colitis - Funding IBD research @CrohnsColitisC3]

@DCAnonBro Studies like this are happening - @predicct for example.

[Kate Low @covil_kate]

Yes Edinburgh is open ✅