Preethi Sekar

Renal Pathologist | MD
Fellow: @UChicago & IKDRC
Decoding biopsies & transplant tech (HLA/Luminex/Flow)
Coimbatore, India 🇮🇳

[Preethi Sekar @PreethiSekarMD]

A case of Membranous nephropathy showing several intracapillary neutrophils and a thrombus. These features can be observed in the setting of renal vein thrombosis and malignancy. #renalpath #pathology

[Preethi Sekar @PreethiSekarMD]

@WCMCPathology @ChangUCanSpare Congratulations!

[Preethi Sekar @PreethiSekarMD]

@ChangUCanSpare Interested

[Jonathan Zuckerman MD PhD @JZRenalPath]

Slowly progressive subnephrotic proteinuria and several year history of everolimus + avastin therapy. Glomeruli with hyaline thrombi-like deposits + TMA features suggestive of VEGF inhibitor associated glomerulopathy. #renalpath #onconephrology https://t.co/7p1ftKrDTJ

[GlomCon @GlomCon]

Join us this Sunday on "Post-transplant Recurrence of Glomerular Diseases" by

Dr. Agnes Fogo @AgnesFogo

Join via zoom
ID 875 5077 1266
Code 202122

sign up https://t.co/PGuM4LyP6c

[Anthony Chang, MD (張賀文) @ChangUCanSpare]

PSA: 2 kidney bxs in last 3 days with hydralazine-associated ANCA GN. #JustSayNoToHydralazine

https://t.co/oYUGXX3eYU

[Sanjeev Sethi @SethiRenalPath]

Now out in print: FAT1-associated MN.

Hematopoietic Stem Cell Transplant-Membranous Nephropathy Is Associated with Protocadherin FAT1.

https://t.co/OW9OISnc1l

[Preethi Sekar @PreethiSekarMD]

Active antibody-mediated rejection:
Glomerulitis
Peritubular capillaritis
C4d peritubular capillary deposition #renalpath

[Anthony Chang, MD (張賀文) @ChangUCanSpare]

TMA webinar on Apr 24 @ 10 am (central). I'll try to simplify this complex topic, which is more common than most believe. It often smolders and is the 2nd diagnosis (aka most commonly missed diagnosis in medicine)
https://t.co/kWGg9u53xu

[Preethi Sekar @PreethiSekarMD]

C4d peritubular capillary staining is frequently seen in ABO-incompatible renal transplants without histologic evidence of rejection and may represent a marker for stable graft accomodation. #renalpath
https://t.co/9h7q2mCzg5

[Lilian Palma🇧🇷 @LilianPalma412]

First report of the Brazilian aHUS Registry - aligned with the Global aHUS Registry, the positivity of genetic findings is 66% and children presented more severe hemolysis. Link for paper: https://t.co/fuwUyEi1ob

[vivek kute @drvivekkute]

@PreethiSekarMD @priti899 @AnandhUrmila @drmanishasahay @krithicism @foreseesaurabh

[Preethi Sekar @PreethiSekarMD]

Elderly male with proteinuria (UPCR 10.2:1)
Biopsy shows: Amyloidosis, AL type (lambda light chain-restricted).
Deposits involve the capillary walls.
Jones silver stain shows "spike" formation ("eyelash effect"). #renalpath #pathology

[Jonathan Zuckerman MD PhD @JZRenalPath]

Pt with ovarian cancer on PARP inhibitor. Bx for proteinuria: chronic microangiopathy with segmental mesangiolysis/hyalinosis which can be seen with anti-VEGF therapy (https://t.co/oCSoqaIF8k). Nephrologist did not know if pt had previously received :(. #renalpath #kidneypath

[Grace Choung, MD 박영이 @grace_choung]

Middle-aged woman with fever, chills, pain in extremities, TIA-like sx, & +anti-MPO. Bx'ed for presumed vasculitis, but found this instead:
Vacuolated podocytes which contain myeloid or "zebra bodies" by EM
Led to genetic testing confirming fabry disease in pt & family.#renalpath

[Preethi Sekar @PreethiSekarMD]

Elderly female with diabetes being evaluated for nephrotic syndrome (UPCR 9:1).
Bx shows: Membranous nephropathy (PLA2R positive) along with diabetic nephropathy changes #renalpath #pathology

[Megan Smith @megothelioma]

Wow, I almost wouldn't have known this was a kidney, but some shriveled glomeruli gave it away. This is a case of autosomal recessive polycystic kidney disease in a <1 month old baby. #PathTwitter #PediPath

[Nicole Arva, MD/PhD @Nicole_Arva_MD]

ARPKD can also be diagnosed on macroscopic examination, showing radially elongated dilated tubules. I added some pictures from our collection. #pedipath #pathtwitter #GUpath #pathology #pathologists

[Pediatric Nephrology @Ped_Neph]

Membranous nephropathy is an uncommon cause of nephrotic syndrome in pediatrics. Read this Original Article that reviews kidney biopsies w/membranous nephropathy w/o evidence of systemic lupus erythematosus within 6 months of biopsy.
https://t.co/gLdlrUvPPS

[Sanjeev Sethi @SethiRenalPath]

Arteritis, with features of severe acute and chronic cellular rejection. Case today.
1) Endothelialitis (blk arrow),acute
2) Endothelial swelling (arrowhead), acute
3) Foam cells (red arrow), chronic

Endothelialitis>25% circumference, in this case 💯=Acute cellular rejection IIB

[Jean Hou, MD @JeanHouMD]

Progressive FSGS: Child w/ FSGS bx'ed in 2019, steroid non-responsive, switched to Tacrolimus, now w/ 40% global glomerulosclerosis and juxtaglomerular apparatus hyperplasia (reported w/ CNI toxicity). GBM variably thickened, podocytes partially effaced. Genetic testing pending.