Emma Lundberg

Assoc Prof. of #bioengineering and #pathology at @Stanford and @KTHUniversity, Director of the HPA Cell Atlas. Interested in cells, imaging and AI.

[Emma Lundberg @Prof_Lundberg]

What would it look like to see all ~13,000 proteins inside a single human cell at once?
We share ProtiCelli — a generative model that makes this possible. Besides benchmarking, we demonstrate utility in many tasks.

Preprint: https://t.co/faBevXiBBa
A thread 🧵👇

[Emma Lundberg @Prof_Lundberg]

7/ It takes a village... Grateful to be part of the fantastic scientific community at @Stanford @StanfordHAI @scilifelab @biohub and @ProteinAtlas !

[Emma Lundberg @Prof_Lundberg]

What would it look like to see all ~13,000 proteins inside a single human cell at once?
We share ProtiCelli — a generative model that makes this possible. Besides benchmarking, we demonstrate utility in many tasks.

Preprint: https://t.co/faBevXiBBa
A thread 🧵👇

[Emma Lundberg @Prof_Lundberg]

6/ This was a fantastic team effort led by @paul39277045 with @K_Kahnert @jn_hansen @wdleineweber Marvin Li, Wanyue Feng, Fredreric Ballllosera Navarro, Ulrika Axelsson and @imweio

[Emma Lundberg @Prof_Lundberg]

3/ We used ProtiCelli to generate Proteome2Cell — 30.7 million simulated images creating 2,400 "virtual cells" across 12 human cell lines. That's multiplexing at 100x the depth of current experimental methods

[Emma Lundberg @Prof_Lundberg]

2/ ProtiCelli lets us do something that has been experimentally impossible: visualize the spatial organization of nearly the entire proteome within individual cells

[Emma Lundberg @Prof_Lundberg]

And of course: A free link to the paper - I hope you enjoy reading it, and that it inspires you to think of proteins and cells in new ways!

https://t.co/SfGU1c8HQk

#openscience

[Emma Lundberg @Prof_Lundberg]

Our review "Subcellular localization as a driver of protein function" is out today in @NatRevMCB!
Thread on why protein subcellular localization matters for biology and medicine 🧵👇
Alina Sigaeva, @CharlH_Science @AnthonyCesnik @lilley_ks
https://t.co/izNljAjF2R

[Emma Lundberg @Prof_Lundberg]

As many of you know, this is a key topic in our research. It was so much fun to write this piece together with @lilley_ks and the next gen superstar scientists in spatial proteomics: Alina Sigaeva, @CharlH_Science, @AnthonyCesnik 🌟🌟🌟

[Emma Lundberg @Prof_Lundberg]

This was a fun collaborative effort, and I'd like to thank everyone involved. Special kudos to Jan Hansen who led the work @jn_hansen 🌟

[Emma Lundberg @Prof_Lundberg]

Excited to present a spatial proteome map of primary cilia! Discoveries range from 91 novel cilia proteins to a novel ciliopathy gene. We hope this resource will be valuable to the #ciliopathy community.

Paper: @CellCellPress
Data: @ProteinAtlas

[Cell @CellCellPress]

Now online! Intrinsic heterogeneity of primary cilia revealed through spatial proteomics https://t.co/zVRgu3Z8JD

[biohub @biohub]

SubCell is a #ML model trained on 1.1M cell images from the @ProteinAtlas representing 13,141 genes + 35 subcellular structures. This new preprint by @Prof_Lundberg + team is the first iteration of a virtual cell model based on images 🧵👇