International Society of Protein Termini (ISPT), we have a shared interest in protein terminal modifications and their downstream effects on protein function.
As we conclude this inspiring conference, we extend our heartfelt thanks to all the speakers, organizers, and participants for their invaluable contributions. See you all in Palermo for the next one.
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Our recent publication led by Ying Meng @Purdue_MCMP explores how NTMT1-mediated Na-methylation affects the stability and interaction of PAD1, offering insights into protein N-terminal methylation. Great contributions on proteomics by Wang lab at UCR. https://t.co/QXN9AEMs8X
As we conclude this inspiring conference, we extend our heartfelt thanks to all the speakers, organizers, and participants for their invaluable contributions. See you all in Palermo for the next one.
#proteintermini24
Final talk of the session and the meeting, Daniel Youngjae Park (Seoul National University) presents ‘Targeted Protein Degradation as a Novel Therapeutic Approach Against Amyotrophic Lateral Sclerosis (ALS)’.
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Thierry Meinnel (Université Paris-Saclay) presents his work on ‘Novel, tightly structurally related N-myristoyltransferase inhibitors with potent yet distinct inhibitory mechanisms’.
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Next up, elevator pitch by Hye Yeon Kim on ‘A novel small-molecule AUTOTAC that selectively degrades pathological tau aggregates and improves outcomes in Alzheimer’s disease’.
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After some excellent work from Yong Tae Kwon, it is now time to hand over the baton to Carmela Giglione @Giglionelab as new leader of the ISPT!
Carmela will also be the host of the next ISPT conference in the sunny Palermo (June 2026)!
Stay tuned 🎉
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Next up: Jihoon Lee discusses ‘Targeted degradation of α-synuclein aggregates in Parkinson’s disease via the AUTOTAC chemical platform’.
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The terminal session of the protein termini meeting kicks off with Emmanuelle Graciet, diving into ‘The N-degron pathway’s role in the crosstalk between hypoxia signaling and plant immunity’.
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Elevator pitch time!
First of the day is Rebecca Latter on ‘Modulation of Arabidopsis thaliana Plant Cysteine Oxidase 4 (AtPCO4) activity’.
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Today's last (flash) talk, Samuel Madden, will tell us about "Plant Cysteine Oxidase (PCO) Oxygen -Sensing Function Is Conserved in Unicellular Algae"
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Next, all the way from Seoul, we will hear from Min Ju Lee, presenting "Degradation of melanosome/melanin and chemical modulation of melanophagy by the N-degron pathway via p62/SQSTM1-dependent macroautophagy".
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Janet Kumita, coming from Cambridge, is next. She will tell us about "The impact of N-terminally acetylated α-synuclein on designing therapeutic strategies to combat Parkinson’s Disease"
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