ISPT_ProteinTermini

International Society of Protein Termini (ISPT), we have a shared interest in protein terminal modifications and their downstream effects on protein function.

[ISPT_ProteinTermini @proteintermini]

As we conclude this inspiring conference, we extend our heartfelt thanks to all the speakers, organizers, and participants for their invaluable contributions. See you all in Palermo for the next one.
#proteintermini24

[Huanglab @rhuanglab]

Our recent publication led by Ying Meng @Purdue_MCMP explores how NTMT1-mediated Na-methylation affects the stability and interaction of PAD1, offering insights into protein N-terminal methylation. Great contributions on proteomics by Wang lab at UCR. https://t.co/QXN9AEMs8X

[ISPT_ProteinTermini @proteintermini]

And last, a quick shoutout to the (almost) full organizing team: @emily_flashman, @Fra_LicO2si and both of their groups! As always, better together.

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[ISPT_ProteinTermini @proteintermini]

As we conclude this inspiring conference, we extend our heartfelt thanks to all the speakers, organizers, and participants for their invaluable contributions. See you all in Palermo for the next one.
#proteintermini24

[Frederica Theodoulou @freddietheodou1]

Just back from an excellent @proteintermini meeting in Oxford. Lovely to catch up with #proteostasis friends and hear about the latest results. Big thanks to @emily_flashman, @Fra_LicO2si and the team for organising 👏

[ISPT_ProteinTermini @proteintermini]

Congratulations to the winners of the best Poster prize - Samuel Zolg, Dani Amat and Anna Dirr. Best talk - Mahima Bhat.
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[ISPT_ProteinTermini @proteintermini]

Final talk of the session and the meeting, Daniel Youngjae Park (Seoul National University) presents ‘Targeted Protein Degradation as a Novel Therapeutic Approach Against Amyotrophic Lateral Sclerosis (ALS)’.
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[ISPT_ProteinTermini @proteintermini]

Thierry Meinnel (Université Paris-Saclay) presents his work on ‘Novel, tightly structurally related N-myristoyltransferase inhibitors with potent yet distinct inhibitory mechanisms’.
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[ISPT_ProteinTermini @proteintermini]

Next up, elevator pitch by Hye Yeon Kim on ‘A novel small-molecule AUTOTAC that selectively degrades pathological tau aggregates and improves outcomes in Alzheimer’s disease’.
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[ISPT_ProteinTermini @proteintermini]

After some excellent work from Yong Tae Kwon, it is now time to hand over the baton to Carmela Giglione @Giglionelab as new leader of the ISPT!

Carmela will also be the host of the next ISPT conference in the sunny Palermo (June 2026)!

Stay tuned 🎉

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[ISPT_ProteinTermini @proteintermini]

Next up: Jihoon Lee discusses ‘Targeted degradation of α-synuclein aggregates in Parkinson’s disease via the AUTOTAC chemical platform’.
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[ISPT_ProteinTermini @proteintermini]

The terminal session of the protein termini meeting kicks off with Emmanuelle Graciet, diving into ‘The N-degron pathway’s role in the crosstalk between hypoxia signaling and plant immunity’.
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[ISPT_ProteinTermini @proteintermini]

Last talk before the break, Mikie Kukwikila from Oxford Nanopore on new advances in protein sequencing.

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[ISPT_ProteinTermini @proteintermini]

Next up, Ron Huang talking about new inhibitors for human N-terminal Methyltransferases.

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[ISPT_ProteinTermini @proteintermini]

Elevator pitch time!

First of the day is Rebecca Latter on ‘Modulation of Arabidopsis thaliana Plant Cysteine Oxidase 4 (AtPCO4) activity’.

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[ISPT_ProteinTermini @proteintermini]

First scientific talk of the day, Beatrice Giuntoli sharing some new insights on substrate discovery for plant Cys N-degron pathway.

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[ISPT_ProteinTermini @proteintermini]

Starting off the last day with some talks from @FEBSnews representatives Matera Mancek Keber and Duncan Wright.

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[ISPT_ProteinTermini @proteintermini]

After a fruitful day of science! Conference dinner at Wadham College.
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[ISPT_ProteinTermini @proteintermini]

Today's last (flash) talk, Samuel Madden, will tell us about "Plant Cysteine Oxidase (PCO) Oxygen -Sensing Function Is Conserved in Unicellular Algae"

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[ISPT_ProteinTermini @proteintermini]

Next, all the way from Seoul, we will hear from Min Ju Lee, presenting "Degradation of melanosome/melanin and chemical modulation of melanophagy by the N-degron pathway via p62/SQSTM1-dependent macroautophagy".

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[ISPT_ProteinTermini @proteintermini]

Janet Kumita, coming from Cambridge, is next. She will tell us about "The impact of N-terminally acetylated α-synuclein on designing therapeutic strategies to combat Parkinson’s Disease"

#proteintermini24