Proton

Interesting ideas & Networking. Opinions are my own/RT/follow/favorites are not endorsements. No money is made from this and please give original poster credit.

[REGENT @regentcraft]

We’re continuing to test and develop our autonomous Seaglider drone, Squire. We’ve proven our max speeds of 70kts – now we’re focused on expanding the platform’s endurance, demonstrating the reliability, resilience, and mission readiness that modern maritime operations demand.

[Object Zero @Object_Zero_]

Single Crystal CVD Diamond

Have no doubt, you are at the dawn of an industrial revolution. There is a string of breakthroughs happening throughout upstream industries that all compound.

Diamond manufacturing is now able to produce CPU size single crystals wafers.

Currently these are marketed as heat spreaders because they have thermal conductivity of 2,200 W/mK which means they move heat incredibly effectively.

However, that somewhat misses the wood for the trees…

Diamond has physical and electrical properties that exceed traditional silicon, making it uniquely suited for high demand applications.

Thermal Conductivity: Heat is the enemy of electronics. Diamond conducts heat better than almost any other known material, about 5 times better than copper and over 10 times better than silicon.

A diamond chip can act as its own heat sink.

Ultra Wide Bandgap: Diamond can handle massive amounts of voltage and operate at incredibly high temperatures without electrical breakdown.

This makes it perfect for high power applications like electric vehicle inverters, power grids, and aerospace technologies.

High Frequencies: Electrons move very quickly through diamond, allowing chips to operate at much higher frequencies, which is ideal for advanced telecommunications and radar.

Radiation Hardness: Diamond is incredibly resilient to radiation, making diamond based chips ideal for satellites, space exploration, and nuclear facilities.

To make a material act as a semiconductor, you have to "dope" it. To do this you inject impurities into the crystal lattice to create a positive (p-type) or negative (n-type) charge.

Diamond's atomic structure is so tightly packed that forcing other elements into it is hard. While p-type doping (with boron) has been figured out, reliable n-type doping (with phosphorus) remains a massive hurdle.

Theoretical ceilings

Band gap
Silicon wafer = 1.1 eV
Diamond CVD wafer = 5.5eV

Clock speed
Silicon wafer = 5-6 GHz clock wall
Diamond CVD wafer = 1-2 THz clock wall

Max Running Temp
Silicon wafer = 150°C
Diamond CVD wafer = 1,000°C

Whilst we etch silicon with photolithography and Extreme UV light, this doesn’t really work with chemically inert diamond.

Diamond CVD is currently etched with oxygen plasma etching, but this lacks the precision of EUV.

However, we can etch diamond to extreme precision with electron projection lithography. EPL was invented in the 90s by Bell Labs, IBM and Nikkon but abandoned as it was harder than EUV.

Electrons repel each other so the beams blurrs too readily.

What if we built a femto electron beam?
What if we built it to extreme such that it was a ‘single electron’ pulse?

What if we build a microscopic "bed of nails" containing millions of nanoscale tungsten or silicon tips (photocathodes). You shine a massive, highly complex femtosecond laser system across the entire array.

Every time the laser pulses, millions of tiny tips each fire a single, perfectly straight electron at the exact same time.

Turns out, research teams at likes of MIT and Stanford are currently experimenting with exactly this, laser driven nanotip electron emitters.

Pair that tool with Diamond CVD substrate tech and we approach the material limits of both semiconductors and nanotechnology.

Would require asynchronous logic to escape fatal clock skew and operate at full capability.

But I think I will live to see it.

[Derya Unutmaz, MD @DeryaTR_]

Another major cancer treatment advance with a personalized mRNA vaccine for melanoma, on top of immune therapy, >70% survival! This fully mobilizes the immune system to destroy the tumor. In fact, it could potentially be applied to most cancers that have specific mutations!

[Owen Brake @OwenBrakes]

NoLoRa: Team from Edinburgh demonstrated LoRa transmission on MCUs with no radio chips, by utilizing the 27th harmonic of the SPI peripheral

[Sholto David @addictedtoigno1]

When trying to purchase an antibody for p16-INK4a dozens of labs seem to have ordered an antibody for "p16-ARC" which has no structural or functional relationship. Papers with hundreds of citations published in Nature, Cancer Cell, and eLife are impacted.

[Sholto David @addictedtoigno1]

Today I'm posting a new blog about an astonishing scientific own goal. Hundreds of papers have reported using a completely wrong antibody to investigate the tumor suppressor p16. This mistake has happened because scientists have muddled the names of two proteins 🧵

[Ali H. Shaib @AliHShaib]

Hello world, meet 1,000× Expansion Microscopy.
1,000,000,000× expansion by volume! A gel that starts at a few centimeters will then expand to the volume of an Olympic swimming pool. https://t.co/E43kxx4O5M
In our new bioRxiv preprint, work carried out between MIT and UMG, led by Helena Hu in collaboration with scientists from the labs of @eboyden3 Ed Boyden, Silvio Rizzoli, and myself, we present Thousandfold Expansion Microscopy.
By enlarging biological specimens across multiple rounds of expansion, molecular-scale features, as small as the distances between adjacent amino acids, can be visualized with conventional optical microscopes.
Democratizing super-resolution microscopy.

[Proton @proton243]

@ZelenskyyUa Well done. /k/

[Jordan Taylor @Jordan_W_Taylor]

I love the fact that if you're motivated, or have a need for simplicity & robustness, you can build a basic logical computer with pneumatic systems.

[SciTech Era @SciTechera]

This could reshape the future of computing.

Scientists just demonstrated a new way to build computer chips vertically instead of only making them smaller and flatter.

Researchers successfully stacked 3 layers of high-performance silicon transistors directly on top of each other using low-temperature processing compatible with semiconductor fabrication limits.

Their monolithic 3D chip architecture achieved:
> Sub-10 nanometer layer alignment
> Processing below 400°C
> Current densities above 650 μA/μm approaching advanced silicon transistor performance

why this matters:

Modern chips are approaching physical scaling limits. But this approach increases computing power by building upward like a skyscraper.

The researchers also demonstrated working logic circuits and SRAM memory directly inside the stacked architecture.

If scalable for commercial manufacturing, this could become one of the most important post Moore’s-Law advances in semiconductor engineering.

[University of Oxford @UniofOxford]

NEW: Oxford researchers have helped to achieve a world first: loading a complete genome onto a quantum computer. This makes an important step towards a future where quantum computing accelerates biological discovery.

Find out more ⬇️
https://t.co/5DROjxivgr

[Proton @proton243]

@FanlessTech I know this is meant for passive cooling… but I want to run coolant through it anyway.

[Frankie™️🦅 @B7frankH]

Ferrari 288 GTO
There are thousands of Ferraris all over the world.
But this one is "Godfather" of all. Last one sold on an auction in Paris 2026 for €9,117,500 (Christie's)
You can glorify your electric car as much as you want but this thing is "Final Boss".

[Gateway @Gateway2Space]

Cape Canaveral residents waking up to one of the biggest manmade non-nuclear explosions in history:

[rari @0xwhrrari]

Claude opus 4.8 dropped and Anthropic released Boris Cherny's prompt workshop

One of the people actually building claude explains how to use it properly

Free
No signup
No paywall

The first 8 minutes are better than most $300 ai courses

Context
Task structure
Cleaner outputs
Fewer wasted prompts

Watch it and bookmark it before this gets sold back to you as a course

[Proton @proton243]

@The_Real_ITDUDE Don’t mess with Burt.

[Shining Science @ShiningScience]

Blocking vitamin B7 shown to completely shut down treatment-resistant tumors.

Oncologists have long known that many aggressive tumors exhibit an extreme "glutamine addiction," depending heavily on this specific amino acid to power their rapid cellular replication.

However, when therapeutic interventions cut off this vital nutrient supply, resilient cancer cells routinely survive by activating an emergency metabolic bypass that utilizes a mitochondrial enzyme called pyruvate carboxylase.

An international research team at the University of Lausanne has discovered that this structural backup system has a fatal vulnerability: it relies completely on biotin—commonly known as vitamin B7—to function. By running a comprehensive functional nutrient-genetic profile, scientists demonstrated that restricting the availability of biotin completely paralyzes this enzyme, trapping the cancer cells in an inescapable state of nutrient starvation that halts tumor growth.

This metabolic trap proved exceptionally lethal in tumors harboring mutations in the FBXW7 gene, a common genetic alteration linked to chemotherapy resistance across a broad spectrum of human cancers.

While this molecular discovery provides a powerful new blueprint for targeted oncology, public health experts emphasize that these preclinical findings are confined to controlled laboratory models and do not mean individuals should eliminate vitamin B7 from their daily diet. Biotin remains a fundamental cofactor for healthy systemic metabolism, nervous system function, and cellular gene regulation in normal human tissues. Instead, the true clinical value of the research lies in the development of highly specific, localized pharmacological agents designed to temporarily inhibit biotin-dependent enzymes directly within the tumor microenvironment.
Reference

Lisci, M., Allen, S. R., & Fendt, S. M. (2026). Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction. Molecular Cell, 86(10), 1845-1859.

[Shining Science @ShiningScience]

Developed by scientists at the University of Florida, the vaccine uses mRNA technology—similar to that used in COVID-19 vaccines—to train the immune system to mount a general attack on tumors. Unlike personalized cancer vaccines, which must be custom-made for each patient, this version is off-the-shelf and ready to use, a potential game-changer for speed and accessibility. Its secret weapon?

It boosts type-I interferons, immune molecules that help the body detect and destroy cancer cells early.

[OSINTdefender @sentdefender]

Some of the best footage yet of tonight’s explosion involving Blue Origin’s New Glenn, during a Static Fire Test at Cape Canaveral Launch Complex 36 (LC-36) in Florida. LC-36 appears to have suffered significant damage, with several towers and other structures entirely missing, likely to require months if not over a year of repair work by Blue Origin, NASA, and the U.S. Space Force.

[Bluntly Put Philosopher (BPP) @SocraticScribe]

A drone flying with no battery tether sounds impossible until you see it. GuRu wirelessly transmitted power through the air to directly run an untethered drone from 30 feet away and has kept one flying for 96 hours straight. Power beaming is moving out of science fiction fast.