Pub Snips 🔬

Ridiculously short, human-written summaries of impactful biological publications written by a PhD scientist (art by David Goodsell)

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Antibody based targeting of CRISPR-Cas9 containing particles for cell type specific and potentially in vivo genome editing https://t.co/1qYdJ2rvdx @biorxivpreprint

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SP140 is an immune-restricted PHD and bromodomain-containing epigenetic reader and topoisomerase inhibitor that maintains heterochromatin for proper macrophage fate and function https://t.co/6iHbuB7s2g @CellCellPress

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GTSF1 is an auxiliary protein that potentiates the weak, intrinsic, piRNA-directed RNA cleavage activities of PIWI proteins https://t.co/RTyWrccFkC @Nature

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cis-RNA editing QTLs (edQTLs) are associated with common inflammatory conditions and reduced editing by ADAR1 contributes to inflammatory disease risk https://t.co/ws28v9zkik @Nature

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Generation of iPSC-derived microglia and use of a CRISPRi screening platform to identify genes involved in survival, phagocytosis, etc - microglia-like cells secrete cytokines, can be cocultured with iPSC-derived neurons https://t.co/XIfhc55k1D @NatureNeuro

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Common non-synonymous SNPS in the serotonin receptor gene 5-HT2AR modestly, but significantly, affect psychedelic efficacy and potency... enter psychedelic pharmacogenomics https://t.co/pVJSsfSJEW

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ADAR1 prevents autoimmunity through A-to-I editing of endogenous Alu RNAs and preventing activation of the Z-nucleic acid sensor ZBP1, a mechanism for Aicardi–Goutieres syndrome
https://t.co/qLCcBnmQZf https://t.co/EdhngrOPXh https://t.co/uJrKHqI6YD @Nature

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150,119 genomes in the UK Biobank, including 585,040,410 single-nucleotide polymorphisms, representing 7.0% of all possible human single-nucleotide polymorphisms, and 58,707,036 indels https://t.co/REi0ffj8AX @Nature

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Intermittent fasting promotes axonal regeneration after sciatic nerve crush in mice through gram-positive gut microbiome and serum metabolite indole-3-propionic acid (IPA) https://t.co/iXSxyjxvR8 @Nature

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Over half of KCNH2 "hot spot" exon 2 variants have no functional effect and a massively parallel trafficking assay predicts functional effects better than REVEL and bioinformatics tools https://t.co/8d1vfjLaff @AJHGNews

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Clinical Variant Analysis Tool (CVAT) helps standardize clinical interpretation of genomic variation for better collaboration and more transparent reporting https://t.co/QVZfcuYL6k @GIMJournal

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DPH5 homozygous and heterozygous missense and frameshift variants are associated with craniofacial abnormalities, multisystem dysfunction, miscarriage and severe neurodevelopmental delays https://t.co/9rZPws5qG2 @GIMJournal @UDNconnect

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Host variation in IL10RB, PLSCR1, BCL11A, FUT2, ATP11A, MUC1, SELE, ICAM5, CD209, F8 predispose to more severe COVID illness https://t.co/cXF6yJaa44 @Nature

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Most enhancers activate all promoters in a similar amount - intrinsic enhancer and promoter activities multiplicatively combine to determine RNA output - housekeeping gene promoters have intrinsic motifs to decrease responsiveness https://t.co/vLutslbImT @Nature

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During sleep, circulating tumour cells (CTCs) are stimulated by circadian rhythm hormones such as melatonin, testosterone and glucocorticoids for increased metastasis potential https://t.co/9vNULOiHMz @Nature

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Persistently elevated CCL11 and the hippocampus may be key in the pathology of long COVID neurologic symptoms https://t.co/DUszQJBgTa @CellCellPress

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If you needed a reminder, we need larger ethnicity-specific genomic datasets @QatarGenome @medrxivpreprint https://t.co/I67R6Ftl1S

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@greally DNA, but not that DNA

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Background nonsynonymous variants (mostly in chaperonin-encoding genes) are in trans and contribute to the recessive Mendelian disorder Bardet–Biedl syndrome (BBS) - we're all looking for a "second hit"! https://t.co/tmINxDmqR2
@NatureGenet

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@UtahWildfire Humans are the problem