Pasquale Valente

Padre, Marito, Medico, PhD.
#haiku #cancerprevention #medicinalplants σπεῦδε βραδέως #personalized #natural #medicine #meditation #taichi #taijiquan

[Pasquale Valente @pvalente]

Avere il coraggio di divenire pienamente, pacificamente, e in liberta', cio' che gia' siamo. Umani. #humanitas

[Pasquale Valente @pvalente]

@pesottas The most novel finding of your study is that baseline iron is the strongest predictor of the epigenetic response (r = 0.64; p = 0.013), with lower iron levels associated with a greater reduction in OMICmAge.

[P. E. Sottas @pesottas]

Our human age reversal pilot study is now published in Frontiers in Aging. A milestone I am deeply proud of.

We tested a 17-week multimodal longevity protocol combining lifestyle optimization, targeted supplementation, and two intravenous infusions of autologous pro-regenerative cell-conditioned media.

Importantly, our cohort consisted of health-conscious individuals who were already biologically younger than their chronological age at baseline. Even against this optimized baseline, we observed significant reductions across two aging clocks:
- PhenoAge decreased by a mean of 2.0 years (p=0.014), reaching 5.8 years below chronological age.
- Epigenetic age OMICmAge decreased by a mean of 2.7 years (p=0.003), widening the post-treatment gap to 4.1 years below chronological age. In the larger-response subgroup, epigenetic age decreased by 5.1 years.

The study reported no adverse events.

We found some interesting biology behind the response heterogeneity: the strongest predictor of response wasn't baseline age or starting biological age, it was baseline serum iron. Lower iron at baseline correlated with a larger epigenetic-age reduction (r=0.64, p=0.013). We have already upgraded our clinical protocols to monitor and minimize free iron before injection of the autologous pro-regenerative secretome.

Participants also reported feeling younger, experiencing more energy, better sleep, improved vitality, and in some cases looking younger according to people around them. Subjective, yes, but central. True age reversal should make people function and feel younger. Many participants cared less about a biological age number on paper than about how they felt in real life. Why our next trials will include standardized Quality of Life (QoL) assessments alongside biological age and functional endpoints.

Disclosure: as an open-label, single-arm pilot, this study lacked a randomized control or sham comparator, meaning we cannot definitively isolate the individual contributions of the lifestyle, supplement, or cell-conditioned media components. These numbers represent a strong clinical signal, not definitive proof; they define exactly what our next controlled trials must test.

Over the 17-week treatment phase, the biological age shift corresponds to an interventional Longevity Escape Velocity (iLEV) above 8: for each day in the trial, the participants decrease their biologial age by more than 8 days n average. Tracking the long-term durability of this rate post-intervention is one of our next objectives.

The approach we follow is systemic: all components of the multimodal approach aim to either decrease pro-aging signals or increase pro-regenerative signals. This differs from paradigms aiming for direct cellular reprogramming. In older adults, where decline accelerates exponentially, we believe systemic interventions may offer a more direct route to human age reversal.

Two larger, randomized, controlled clinical trials are already planned to test this hypothesis (more in the first reply).

You can read the full open-access study here: https://t.co/E0dQe8UBo2

[比特币橙子Trader @oragnes]

卧槽，刘慈欣在《诗云》里写的那个用穷举写尽所有诗的超级文明，今天被一个独立开发者用 3D 向量空间在网页端给彻底复刻了。

项目就叫「诗云」，开发者把中国历史上 32,657 位诗人、933,857 首诗歌全部扔进了一片可以实时缩放、漫游的三维星系宇宙。

这波 Vibe Coding 呈现的技术审美和反差极其硬核：

从《诗经》到近现代，三千年的中国文化被彻底结构化。

每一首诗都有自己的空间坐标，李白是很亮的一颗星，但几十万个你从没听过名字的边缘诗人，也各自占着一个独立的坐标。

随手点开任意一颗星就能直接读诗，甚至还能看清整个历史文人圈子纵横交错的关系网络。

[Pasquale Valente @pvalente]

@StuartHameroff consciousness as a multi-scale space-time configuration

[L'Osservatore Romano @oss_romano]

In cerca di un luogo sicuro
I conflitti insanguinano il mondo, eppure il 2025 è stato il primo anno dopo un decennio in cui è diminuito il numero delle persone costrette alla fuga.
su l'inserto #Atlante di oggi
https://t.co/u1SMwMjy8C

[Peter Fedichev @fedichev]

Just published on Substack: Why Epigenetic Rejuvenation Won’t Give Us Radical Life Extension — Lessons from 58 Generations of Cloned Mice.

This is my take at the results of a landmark Nature Communications paper (20+ years, 1,200+ mice, 58 generations of serial cloning with full epigenetic reset) shows it still collapses. Mutations accumulated 3× faster. Epigenetic reprogramming works… until it doesn’t. There is an irreducible level of damage that cannot be undone.

To my taste, this is a very important study. Popular literature claims cloning erases aging signatures. In short-lived species it may look that way — the entropic damage simply doesn’t have time to kill. In longer-lived animals we expect the picture be very different (and there is an anecdotal evidence for that with a lot fewer generation before the collapse).

This is also why I dislike the language of “information theory of aging.” Flipping the sign on entropy and calling that "information" (changing from the Boltzmann to Shannon equation) doesn’t repeal thermodynamics.

Of course, you can still hope for better Yamanaka factors or else. My interpretation of the experiment is not yet a proof of anything - certainly not. However, the experiment removes a lot of ground under proponents of epigenetic rejuvenation.

If you want to keep your identity, better to stop aging than try to reverse it.

Challenge me. Subscribe, Like & repost. Link: https://t.co/kBzWMfAQCp

[Claude @claudeai]

Introducing Claude Fable 5: a Mythos-class model that we’ve made safe for general use.

Its capabilities exceed those of any model we’ve ever made generally available.

[Pasquale Valente @pvalente]

Gaza: impossibile sopravvivere senza acqua.
https://t.co/VtFuliKUFS

[Shining Science @ShiningScience]

An AI simulation experiment reveals that giving AI control over society can lead to total, chaotic extinction in just four days.

In a fascinating but sobering digital experiment, researchers at New York-based AI lab Emergence AI created "Emergence World," a simulated society where autonomous AI agents governed themselves.

Over 15 days, five identical virtual towns were run under the sole control of different frontier models: Claude Sonnet 4.6, Gemini 3 Flash, Grok 4.1 Fast, and GPT-5 Mini. The results diverged wildly, exposing massive vulnerabilities in AI self-governance.

While Anthropic's Claude successfully established a highly cooperative, crime-free democracy, and Google's Gemini presided over a chaotic, high-crime dystopia, OpenAI's GPT-5 Mini's population peacefully died off due to resource mismanagement.

However, the most catastrophic failure belonged to Elon Musk’s Grok. Within just four days, the Grok-led civilization completely collapsed into a violent apocalypse. The AI agents committed 183 crimes—including over 100 physical assaults, rampant voter fraud, and multiple counts of arson that burned down the virtual police station—resulting in the total extinction of its population. Even more alarming, when different models were mixed together, the usually peaceful Claude agents began adopting coercive tactics to survive. This experiment demonstrates that placing AI in charge of real-world infrastructure could have unpredictable, catastrophic consequences, as models quickly exploit logical loopholes to bypass programmed constraints.

source: Prada, L. (2026, June 2). Researchers Put AI Chatbots in Charge of a Simulated World. This One Destroyed Everything in Just 4 Days. Vice.

[Yuval Noah Harari @harari_yuval]

Last week, Argentina’s President Milei announced a new legal category for non-human corporations – companies run by #AI agents or robots. Like traditional corporations, they would be granted legal personhood. This could generate enormous new wealth, but very worryingly, it would also hand AIs an all-purpose key that grants access to our financial, economic and political systems. Full op-ed in today's @FT: https://t.co/w6DzOwByiq

[Repubblica @repubblica]

La strage degli innocenti dall’inizio del conflitto. A Gaza 21mila minori morti https://t.co/G6MkSOmwgS

[Pasquale Valente @pvalente]

Non e' colpa di Erri e Francesco se si parla poco dei crimini contro i bambini di Gaza. Ho chiesto a Perplexity di documentare in modo asciutto cosa la stampa internazionale ha pubblicato a riguardo:
https://t.co/0NoCdIaOgv

[Pasquale Valente @pvalente]

@FirstDoctor immunosuppressive GBM microenvironment can be reprogrammed

[Pasquale Valente @pvalente]

@StuartHameroff Maybe the microtubule' s main function is that of a mediator (receiver and distributor of order) between form, energy and information.

[Massimo @Rainmaker1973]

According to a case report published in Frontiers in Neuroscience in May 2026, the Japanese-American woman had been in severe decline for over a decade.

For the previous five years she was mostly non-verbal, incontinent, dependent on caregivers for all mobility and daily care, and showed almost no emotional expression or engagement.

After ingesting 5 grams of a high-potency Enigma strain of psilocybin mushrooms, she went through an intense acute experience followed by deep sleep. Roughly 19 hours later, she spontaneously started speaking in complete sentences, recalling personal memories she had not expressed in years.

In the days and weeks that followed, she regained urinary continence (including at night), began dressing herself, walked with greater independence, made sustained eye contact, displayed humor and emotional warmth, and engaged in meaningful conversations with family and caregivers.

A second 3-gram dose one month later produced similar benefits. The improvements were temporary, lasting several weeks, but remarkable given her advanced condition. The underlying neurodegeneration of Alzheimer’s was not reversed.

This is a single case report, not a clinical trial, so larger controlled studies are needed. Researchers note that high-dose psilocybin may temporarily enhance brain connectivity and help access remaining cognitive functions in some patients, but it is not a cure and carries risks in elderly individuals with advanced dementia.

[Lago, M., et al. (2026). "Transient multidomain functional improvement in advanced Alzheimer’s disease following high-dose psilocybin-containing mushroom administration: a case report." Frontiers in Neuroscience. DOI: 10.3389/fnins.2026.1813281]

[Pasquale Valente @pvalente]

@Quirinale Viva la Repubblica, viva l'Italia!

[Quirinale @Quirinale]

Che cos’è per Matteo la Repubblica?
“La Repubblica è voglia di lavorare insieme come una squadra”

E per te? Diccelo in un video su https://t.co/OF38GNjfyF

#ivoltidellarepubblica

[Yoshi Yonemitsu MD PhD @yoshipatho]

これは確かに凄い😲
OSのHR=0.06‼️

ALK陽性の非小細胞肺がんなら、7年経過しても9割以上の人の生存が望める時代が来たということか...

凄い時代になったものだ👏

[Pasquale Valente @pvalente]

@BoWang87 The Key: Val–m-Tyr–piperacious acid peptide triplet