Pyry Sipilä

Epidemiologist

[Pyry Sipilä @PyrySipila]

The role of frailty and comorbidities in severe infections and the risk of dementia: a prospective, multicohort, observational study
https://t.co/oXUUXMy1Lg

[Pyry Sipilä @PyrySipila]

The role of noninfectious comorbidities in the association between severe infections and risk of dementia in Finland: A nationwide registry study https://t.co/MR6AobaRbg

[Pyry Sipilä @PyrySipila]

Adult obesity and risk of severe infections: a multicohort study with global burden estimates - The Lancet https://t.co/DLE0h9zlR3

[Pyry Sipilä @PyrySipila]

A study finds that eating disorder patients with type 1 diabetes receive hospital treatment for their eating disorder less often than those eating disorder patients who do not have diabetes. https://t.co/fZB8fkvKZo

[Pyry Sipilä @PyrySipila]

Association of LEAF-Q and EDE-QS scores with cholesterol levels in Finnish female athletes https://t.co/zimz8L0wdH

[Pyry Sipilä @PyrySipila]

Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline
https://t.co/YDkmeYSL39

[Pyry Sipilä @PyrySipila]

Proud of PhD student Leon Hirvelä from our department, whose paper about broad eating disorder symptoms and alcohol problems was published on Friday. https://t.co/j15k7iFhCj

[Mika Kivimaki @MikaKivimaki]

Predicting long-term risk of #dementia for cognitively healthy individuals is challenging. Error rates are very high even with the risk scores currently used in research and health care.
@Gill_Livingston @epiAgeing @PyrySipila

https://t.co/BHE27vyGq1

[Circulation @CircAHA]

#ICYMI: Severe Infection and Cardiovascular Disease @PyrySipila @MikaKivimaki @uk_biobank @wellcometrust #AHAJournals

[Circulation @CircAHA]

#OriginalResearch: In this multicohort study, hospital-treated infections associated w/ significant increase in short-term risk and modest long-term risk of major CVD events. @MikaKivimaki @nellimarikki@PyrySipila #AHAJournals https://t.co/51JSJkS6l4

[Samuli Ripatti @samrip]

This massive study combined evidence for the link between autoimmune diseases and dementia using 6 different big-data approaches.

The work was lead by @jlindbohm and @ninajmars with contributions from @pyrysipila, @heikorunz, @Gill_Livingston, Ramnik Xavier and many others

[Mika Kivimaki @MikaKivimaki]

Observational evidence suggests:
–#Obesity decreases disease-free years much more than longevity.
–The proportion of #multimorbidity by age 75 in people with healthy weight was reached already by age 55 in those with obesity.
#multicohort #UKBiobank

https://t.co/lhimCjy91f

[The Lancet Healthy Longevity @LancetLongevity]

What causes dementia? 2 studies using retrospective cohort data find that risk of developing #dementia increases after having a serious #infection. What does this mean for #LongCovid?
@TheLancetInfDis https://t.co/4qAtCAeTPh
@LancetLongevity https://t.co/LUN7IktlTQ

[Mika Kivimaki @MikaKivimaki]

If anti-amyloid drugs do not prevent clinical dementia, what are the alternatives? This paper identifies 15 new protein targets for #dementia drug development.
#Whitehall study #ARIC study
@jlindbohm @gill_livingston @gottesman_lab
https://t.co/qCXbrB3e7J

[The Lancet Infectious Diseases @TheLancetInfDis]

New research Article: Hospital-treated infectious diseases and the risk of #dementia: a large, multicohort, observational study with a replication cohort 🇫🇮🇬🇧 https://t.co/AfNMjGVgY3

[Mika Kivimaki @MikaKivimaki]

Multicohort study links #infections to #dementia risk:
- stronger effects on vascular dementia than Alzheimer’s
- attributable to general inflammation rather than any specific pathogen
- systemic infections sufficient to affect the brain.
@UK_Biobank
https://t.co/udAaOr7YUf

[Mika Kivimaki @MikaKivimaki]

Amyloid and tau have dominated pathophysiological models of dementia aetiology.
This preprint identifies 15 novel proteins associated with cognitive decline and dementia.
@Whitehall2study #ARIC @JLindbohm @gottesman_lab @epiAgeing @Gill_Livingston

https://t.co/yqDtxwyqrb

[Mika Kivimaki @MikaKivimaki]

For comparison, mild traumatic brain injury with loss of consciousness is also associated with a ~2-fold increase in the risk of dementia diagnosis

https://t.co/hio335GZBi

[Mika Kivimaki @MikaKivimaki]

NEW multicohort study: #BingeDrinking a long-term #dementia risk factor even if a person usually drinks moderately.
Alcohol-induced loss of consciousness linked to a 2-fold increased dementia risk among both moderate and heavy drinkers.

https://t.co/omh0yLO35m

[Mika Kivimaki @MikaKivimaki]

Risk factors, such as hypertension, obesity and physical inactivity are targets of #dementia prevention. New research suggests that many inflammatory diseases (gastritis, duodenitis, erysipelas) may be equally strong long-term predictors of dementia. https://t.co/WmVgqp2dh3