Bukkie.Y

PhDing, Chemistry & Biochemistry| Luxury Addict | She/Her |GSC Ambassador| Mom-ing my way through life |

[Bukkie.Y @qbyusuph]

!!!

[Bukkie.Y @qbyusuph]

If you have the resources for @Tesla I highly recommend trying it out 😁

[Bukkie.Y @qbyusuph]

@PhD_Genie Consistency will yield those results. Keep showing up

[Tola @adetolaov]

I’d say this slowly:

Refuse to let anyone define you by single moments in your life, whether mistakes you made or victories you won. Accept that you are more than both.

[Bukkie.Y @qbyusuph]

@schmidtim 😂😂

[Bukkie.Y @qbyusuph]

#BlackInChemGradSchool101

Grad school can be challenging, so starting to read journals early & tracking your references can help reduce pressure. Building a community and staying involved is also important; finding balance is key to your well-being. Remember, you’re not alone🥰

[Bukkie.Y @qbyusuph]

@calculus_ng Mix all of them 🌚

[Bukkie.Y @qbyusuph]

@hadjimart1 @OleMiss Ameen and you too

[Bukkie.Y @qbyusuph]

It is that time of the year again 💃🏼💃🏼

#BlackInChemRollCall

Hi everyone,

I am Quadrat , a 4th Year Ph.D student @Olemiss where I am mapping Glycans topography using CF3 radical & Tandem Mass Spectrometry.

Glad to connect with y’all.

[Bukkie.Y @qbyusuph]

@sonsydarlin @OleMiss 8. Understanding the surface structure of glycans helps us:
a. Learn how viruses or bacteria stick to our cells.
b. Design better vaccines, diagnostic tools, or therapies.
•Discover new ways to target diseases that rely on sugar–protein interactions (like cancer )

[Bukkie.Y @qbyusuph]

@sonsydarlin @OleMiss Imagine Glycans as Trees and Proteins as Forests
1. Glycans are complex sugar chains found on the surface of cells, like branches and leaves sticking out from a tree.
2. These glycans help cells communicate, fight infection, and carry out many essential functions,

[Bukkie.Y @qbyusuph]

@sonsydarlin @OleMiss c. Then it analyzes the weight of each piece, allowing us to determine which pieces have the CF₃ tag and therefore were exposed.
d.With this information, we can reconstruct a 3D-like surface map of the glycan (what’s on the outside, what’s hidden, and what’s interacting).

[Bukkie.Y @qbyusuph]

@sonsydarlin @OleMiss 7. After the glycan is hit with CF₃ radicals:
a.Tandem Mass Spectrometry (MS/MS) is like a powerful scanner that can read exactly where the CF₃ paintballs landed.
b.First, it breaks the glycan into smaller pieces.

[Bukkie.Y @qbyusuph]

@sonsydarlin @OleMiss 3. But to really understand what glycans are doing, we need to map their surface: which parts are exposed, which are buried, and which interact with proteins. This surface map is what we call glycan topography.

[Bukkie.Y @qbyusuph]

@sonsydarlin @OleMiss 6. And we call the process of adding the CF3 “footprinting” : because the radicals leave marks where they hit, just like footprints in wet sand.

[Bukkie.Y @qbyusuph]

@sonsydarlin @OleMiss 5. CF₃ radicals are extremely reactive particles that randomly stick to exposed spots on the glycan.
If a spot is buried or shielded (perhaps by a protein), the paintball can’t hit it. So, wherever these radicals stick, we learn: “Aha! That part of the glycan is accessible.

[Bukkie.Y @qbyusuph]

@sonsydarlin @OleMiss 4. And think of CF₃ (trifluoromethyl) radicals as tiny paintballs fired at the glycan “tree.”

[Bukkie.Y @qbyusuph]

@sonsydarlin @OleMiss just like how leaves help a tree interact with its environment.

[Bukkie.Y @qbyusuph]

@calculus_ng @OleMiss Oga mi sir

[Bukkie.Y @qbyusuph]

@Atobatele_1 @OleMiss Thank you

[Bukkie.Y @qbyusuph]

@Habeebok3 @OleMiss 😂😂