Kyuto Sonehara

Postdoctoral Fellow at @SangerInstitute
(formerly working at @UTokyo_News_en and @UOsaka_en)
Interested in statistical genetics and computational biology

[Kyuto Sonehara @qsonehara]

Honoured to give an oral presentation at #ASHG2025🧬 in Boston!
I'll present tomorrow (!) a WGS study of psoriasis focused on structural and rare variants.

📅Wednesday, October 15, 11:30-11:45
🏡Room 253ABC (Level 2)

[Georgios (Yiorgos) Kalantzis @YiorKalantz]

Pleased to announce that our paper, Meta-analysis across six global biobanks identifies recessive coding associations with complex traits and diseases, is now officially published by @AJHGNews.
A quick 🧵 below:

https://t.co/fpnNzf17nO

#recessive #GWAS #metaanalysis #genomics

[Shinichi Namba @NambaShinichi]

Just out in @Nature🚀
GWAS treats genetic effects as fixed —but they’re not always.

Using large biobanks, we map gene–environment interactions and show how dynamic genetic effects enable environment-aware polygenic prediction and drug discovery.
https://t.co/Aju4sqy15t

[YukinoriOkada @okada_yukinori]

Our Platforms & Finalists #ASHG2025🎉🧬
@qsonehara SV & RV psoriasis risk by WGS: CERCAM as novel risk gene
Sugahara K. East Asian GWAS of serum immunoglobulin & subclass for humoral immunity
@Go_Sato_UT Male genetic regulation of germline & somatic Y chr variation shape T2D risk

[東京大学 | UTokyo @UTokyo_News]

[プレスリリース] 全ゲノムシークエンス解析により乾癬の新規関連遺伝子を発見――見逃されてきた希少変異と構造変異の関与を解明―――医学系研究科・医学部
https://t.co/nLUsZcM59X

[Cell Genomics @CellGenomics]

Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene https://t.co/zctV44aJeD

[Kyuto Sonehara @qsonehara]

I would like to thank @okada_yukinori, all other collaborators, and participants supporting this study. Thank you, all! (5/5)

[Kyuto Sonehara @qsonehara]

Excited to share our whole-genome sequencing study on psoriasis out in @CellGenomics!
Looking into rare and structural variants highlighted the disease genetics that conventional GWASs have overlooked.
https://t.co/o7IDlhVX3I

[Kyuto Sonehara @qsonehara]

As in-vivo validation, Cercam-knockout in a psoriasis mouse model showed aggravated dermatitis with elevated T-cell retention in the subepidermis. (4/5)

[Go SATO @Go_Sato_UT]

Our new paper in Nature Genetics!!
Single-cell deconvolution of various somatic mutations including mCAs, loss of Y, and mt-heteroplasmy.
https://t.co/2D2QHmUjps

[Ryuya Edahiro @RyuyaEdahiro]

Our Japanese multi-omic immune cell atlas is out in @NatureGenet!
We projected omics layers — from germline/somatic mutations to metagenomics — into single-cell space to uncover dynamic immune regulation.

https://t.co/H5BRqlxi0M

[東京大学 | UTokyo @UTokyo_News]

[プレスリリース] COVID-19ワクチン接種時の免疫獲得に関わる遺伝子の発見――生まれつきのゲノム変異と後天的なゲノム変異の関与が明らかに―――医学系研究科・医学部
https://t.co/hBvlF4Jdnf

[Cell Genomics @CellGenomics]

Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity https://t.co/npKoXZrQee

[YukinoriOkada @okada_yukinori]

Germline ＆ somatic mutations at MHC & IGH define COVID-19 vaccine immunogenicity. mCA at 6p-MHC, 14q-IGH, mosaic loss of sex chromosome decrease vaccine titer but increase infection, allergy, rheumatic disease risk. @qsonehara @HoNamkoong @CellGenomics
https://t.co/sJIbl1sztj

[Kyuto Sonehara @qsonehara]

I would like to thank Dr Yoshifumi Uwamino, @okada_yukinori, @HoNamkoong, and all other colleagues, collaborators, and participants for their valuable contribution!

[Kyuto Sonehara @qsonehara]

Our paper on germline/somatic mutations influencing COVID-19 vaccine immunogenicity is out @CellGenomics!
https://t.co/FAOleAZCvX

[Kyuto Sonehara @qsonehara]

We further examined haematopoietic mosaic chromosomal alterations. In agreement with the germline variants, these somatic alterations at MHC/IGH also impaired the immunogenicity, while they conferred the risk of infectious/immune-related diseases.