Delighted to finally share our study - the result of a lot of hard work by Dr McClure and the last published before our team’s move to @EdinburghUni@EdinUni_IGC!
New #BasicScience in #OAC this work from McClure et al. uses lipodystrophy mouse models to investigate the effects of systemic versus intra-articular adipose tissue dysfunction on the knee.
https://t.co/KiddJfr8iI
New #BasicScience in #OAC this work from McClure et al. uses lipodystrophy mouse models to investigate the effects of systemic versus intra-articular adipose tissue dysfunction on the knee.
https://t.co/KiddJfr8iI
Novel insights into fibroblast taxonomy:
▶️ link between ontogeny and phenotypic diversity
▶️ functional specialization in response to injury
▶️ Sox5 and Foxo1 emerged as key transcription factors
🔗 https://t.co/uCfv1vw4Ut
Our latest manuscript identifying the taxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolution
https://t.co/51KpgT2PO8
@VersusArthritis @ScotVArthritis
Gdf5-lineage synovial #fibroblasts (SF) are key pathogenic in inflammatory #arthritis
IL-6 --> Yes-associated protein (Yap) complexing with Snail ➡️drive the invasiveness of SF
https://t.co/K3LUwnCrrx
After a quick trip up to our Foresterhill campus, HRH is now meeting academics and students from our Centre for Arthritis and Musculoskeletal Health. @ClarenceHouse
#YAP is a #mechanosensitive transcriptional activator with a critical role in #cancer, #regeneration & #organsize control. Interestingly, force applied to the nucleus directly drives YAP #nuclearimport by reducing mechanical restriction in nuclear pores. https://t.co/dBQBY0qENx