Ranjan Kumar Maji, PhD

postdoc @ Inst. of Cardiovascular Regeneration, Goethe Universitätsklinikum, computational biology, multi-omics, deep learning, small RNA-informatics

[Itai Yanai @ItaiYanai]

'Night science' is what you do when you're not sure what's the question.

[Nature Methods @naturemethods]

Out today from the Schwartz lab! A new way to study cell-cell communication from spatial transcriptomics data. Cell Neural Networks on Spatial Transcriptomics (CellNEST) can detect both signals between individual cells and relay networks of communication. https://t.co/bb0fwtp5ep

[Itai Yanai @ItaiYanai]

For clear thinking, cultivate passionate indifference. Buddhists call it non-attachment. We all have hopes, desires and ambitions. Non-attachment means acknowledging them, accepting them, and then not inserting them into a process that has nothing to do with you.

[Itai Yanai @ItaiYanai]

When your kids ask you what you did to save US science in the crisis of ‘25, you will say that you showed up! Please spread the word and join us!!

[Prof. Nikolai Slavov @slavov_n]

This rate of validation suggests that antibodies should be considered non-specific until proven otherwise:

357 validated out of 1,124 tested.

.

[Itai Yanai @ItaiYanai]

This classic book on creativity stresses two tools that have helped me a lot:
1. "The Morning Pages", a daily ritual of writing 3 pages on anything that comes to mind, and
2. "The Artist Date", a dedicated block of time to go for a walk and think about how the project is going.

[Itai Yanai @ItaiYanai]

Knowing how to give a good talk is a crucial skill to have, but it's mostly not formally taught very well. Here's my strategy for how to prepare for the presentation, actually present it, and then answer the questions.

[Top Science @isciverse]

Science and writing, thinking and rethinking

[Itai Yanai @ItaiYanai]

I think most of it is inhabiting the data.. if you are really trying to get a full understanding of a mechanism, then every piece of data either fits or doesn't fit.. it's always trying to live inside the data and use it to test the structure. – Ellen Rothenberg

[Itai Yanai @ItaiYanai]

What to look for in a science buddy

[Chenxin Li, PhD (@chenxinli2.bsky.social) @ChenxinLi2]

In addition to applied statistics, I have another repository on Data visualization: "quick data vis" (https://t.co/87bQt5Ac6z). It used to be under "Online_R_learning" but now has its own repository on GitHub. I have used this content to teach 1st year grad students for 3 years.

[Itai Yanai @ItaiYanai]

#1 rule of talking with your science buddy: always make them look good. Good ideas and improvisations only flow when everyone is feeling comfortable and secure.

[Fabian Theis @fabian_theis]

Excited to share our atlas build&use guide, out @naturemethods today. Led by @KHrovatin & @SikkemaLisa w @MDLuecken, our review highlights best practices for building, sharing, and leveraging atlases to unlock new biological discoveries. 🌍@humancellatlas
https://t.co/K48r85HuEI

[Tami Geiger (lab) @LabGeiger]

👀New on bioRxiv: Our high-throughput #SingleCellProteomics pipeline analyzing 1,536 single cells/experiment, identifying 3,000+ proteins/cell. Applied to tumor macrophages in a lung metastasis model, we found ~500 differentially expressed proteins. 🔗 https://t.co/KWB0zaWXCS

[Lior Pachter @lpachter]

There are three plots in this figure and all are terrible at conveying what they are intended to convey.

[Sushmita Roy @sroyyors.bsky.social,genomic.social @sroyyors]

https://t.co/SPPFABmq3P

[The Nobel Prize @NobelPrize]

Newly awarded literature laureate Han Kang’s work is characterised by this double exposure of pain, a correspondence between mental and physical torment with close connections to Eastern thinking.

In Han Kang’s short story 에우로파 (2012; ‘Europa’, 2019), the male narrator, himself masked as a woman, is drawn to an enigmatic woman who has broken away from an impossible marriage. The narrative self remains silent when asked by his beloved: “If you were able to live as you desire, what would you do with your life?” There is no room here for either fulfillment or atonement.

#NobelPrize

[Oren Gottfried, MD @OGdukeneurosurg]

Immune system one pager

[The Nobel Prize @NobelPrize]

MicroRNA genes have evolved and expanded within the genomes of multicellular organisms for over 500 million years.

Today, we know that there are more than a thousand genes for different microRNAs in humans, and that gene regulation by microRNA – discovered by this year’s medicine laureates – is universal among multicellular organisms.

#NobelPrize

[annalisa marsico @lisamar2017]

feeling particularly proud of our latest microRNA paper today @bulutkarslioglu @lambosaur and of my favourite (post-doc) paper from my time @VingronLab the PROmiRNA model https://t.co/6uYQ848GaM