Rachel Bennett

Neuroscientist investigating Alzheimer’s, brain vasculature, & tau tangles. Asst Prof @MGH_RI & @harvardmed. 🧠 🔬 ☕️ 🔁 she/her

[Rachel Bennett @RBennett_PhD]

More clues that blood vessels are a key component of changes taking place in Alzheimer's disease, this time we focused on white matter:
https://t.co/ACzW4SZlKo

[Sudeshna Das, PhD @sdas617]

1/4: So nice to our manuscript on role of underdog #astrocytes in #Alzheimers finally in print:
https://t.co/V4NH2HkDGT
@MGHNeurology @MGHNeuroSci @AlSerranoPozo @ayushnoori @li132285 @MGH_RI

[Rachel Bennett @RBennett_PhD]

@sdas617 @ayushnoori Way to go @ayushnoori!

[Transduce this @Reallyviral]

https://t.co/ztvJ9h8RdK

[Rachel Bennett @RBennett_PhD]

Hey @PhDMarie I had so much fun speaking with you for this @PBtScience episode. Thanks for the opportunity to reflect on life in science and speak about some of my favorite things.

[People Behind the Science @PBtScience]

This new episode with @RBennett_PhD covers her research on how changes in blood vessels may contribute to #Alzheimers disease, mentors who shaped her career, major challenges she has overcome in #science, life outside the lab, outdoor adventures, & more.

https://t.co/7Kdps8KVCR

[Biomedical Picture of the Day BPoD @BPoD_s]

#Twophotonmicroscopy & image analysis provides insight into relationship between #tau neurofibrillary tangles & #neurons in #Alzheimers mice model & human tissue. Image & research by @Stray_Scientist et al @MGH_RI @harvardmed in @CellReports. On https://t.co/qKZKNcqM3e

[Rachel Bennett @RBennett_PhD]

In Alzheimer's the presence of neurons with tau tangles is a close correlate for neuron loss BUT in new 2P longitudinal imaging work from the lab we show that neurons with tangles live while neurons without tangles die. I'm surprised, are you? @MGH_RI :
https://t.co/dc0yn9Qffg

[Rachel Bennett @RBennett_PhD]

In people w/ Alzheimer's, blood vessels are tortuous and irregular just like what we reported in tau models in 2018. In our new work, we show that there's a lot more perivascular tau than previously thought. Read about clear brains + vascular tau here: https://t.co/Bm3Ipwim6d

[Rachel Bennett @RBennett_PhD]

@hoppzor @UTHealthSA @CaitlynFastenau @GeroScienceAGE Nice work--I learned a lot reading the discussion! Are α-2,6 N-SA groups on proteins on the extracellular surface of microglia or are they internalizing proteins/lipis with α-2,6 N-SA?

[Rachel Bennett @RBennett_PhD]

What causes cognitive impairment in MS and other neurodegenerative diseases? Colleagues Becky Gillani and Ted Zwang just published some SUPER(resolution) imaging work examining synapses. Neuroinflammation alters stability!

[Mass General Brigham Research @MGBResearchNews]

In a recent study published in the Journal of Brain, Behavior, and Immunity, researchers from @MGHNeurology and colleagues investigated MS and synapse damage from inflammation.

Read more: https://t.co/43nlyVmSYt @mghneurosci

[Rachel Bennett @RBennett_PhD]

Invisible tau and shunned neurons? A little teaser for work we have been doing with Brad Hyman and Ted Zwang. More to come soon (I hope)! https://t.co/Bxffm5bj39

[Rachel Bennett @RBennett_PhD]

snRNAseq studies deserve >1 publication to really break down ALL the data. Woodbury et al. examines microglia changes across brain regions and disease stages in AD, following up on our report from endothelial cells in the same donors. Happy reading! https://t.co/65xygc4aAP

[Rachel Bennett @RBennett_PhD]

@arambling_rosie @BevDavidsonCHOP I think this is a real game changer--awesome work showing that a gene therapy approach could help in AD. Nice job Rosie!

[Rachel Bennett @RBennett_PhD]

Do tau tangles kill neurons? Come debate the evidence with me this afternoon at poster 58. #tau2024

[Rachel Bennett @RBennett_PhD]

Combined immunolabeling for tau and blood vessels in thick tissues reveals accumulation reminiscent of CAA?! This preprint describes what we've been up to recently: https://t.co/hbSF8g3kWj

[Rachel Bennett @RBennett_PhD]

@macauleylab @YNHH Sending positive vibes your way

[Rachel Bennett @RBennett_PhD]

The new, improved peer-edited version of our work describing #endothelialcells across multiple brain regions and in #Alzheimers disease is up on J Neurosci!
https://t.co/6Lcbd6fvuK

[Rachel Bennett @RBennett_PhD]

Nice summary of our transcriptomics study! 👇I’m so excited that endothelial cells get their moment in the spotlight and looking forward to a continued dialogue about how we can use these data to improve brain vascular health and reduce #Alzheimersdisease

[Alzforum @alzforum]

A new atlas of endothelial cell gene expression identified regional diversity in human brain, as well as large effects of #alzheimersdisease pathology. @MassGeneralNews https://t.co/vVRlT25n7c

[Rachel Bennett @RBennett_PhD]

Also, this is a first foray into the world of snRNAseq, R and pre-prints for me. It's been a crazy learning experience, I know there is a lot left to unpack. Also, I'm so thankful of and impressed by those of you who have paved the way for the rest of us. 🥰🙏3/3

[Rachel Bennett @RBennett_PhD]

New pre-print! Are endothelial cells from different brain regions all the same? How are they impacted by the temporal progression of AD pathology? We wanted to know and performed a giant snRNAseq study using 5 different cortical areas 1/3 https://t.co/C7zaTn4lXu

[Rachel Bennett @RBennett_PhD]

This is only a subset of the total snRNAseq study. For the companion piece examining astrocytes please see 2/3: https://t.co/XxnK4ZpcOu