Citizen Science Foundation

[Citizen Science Foundation @realCSF]

📍 For those in the St. Petersburg/Tampa/Clearwater area:

🎥 A screening of The Cholesterol Code will take place April 6th at the AMC Sundial in St. Petersburg, FL at 7:00pm

🎙️Join host Siouxie Boshoff, @ifixhearts, @AnnetteBosworth, @doctorkiltz, Dr. Nelson Vazquez, and @realdavefeldman for a Q&A following the film.

🎟️: https://t.co/wrdNFhzAs9

Proceeds from this fundraising event to benefit Citizen Science Foundation @realCSF.

Hope to see you there!

[Citizen Science Foundation @realCSF]

What an incredible weekend at CoSci 2026 🙌

We’re beyond grateful to everyone who joined us—attendees, speakers, and sponsors—for making this event so special. 💙 Your energy, curiosity, and passion created something truly meaningful… more than just a conference, but a community coming together to share ideas, learn, and connect.

Whether it was your first CoSci or you’ve been with us all three years, seeing the impact this event had on so many of you is what made it all worthwhile. ✨

Thank you for supporting the Citizen Science Foundation @realcsf and being part of this journey with us. 🙏

#CoSci26 #CitizenScience #ThankYou #Gratitude #Community #Science #MetabolicHealth #LasVegasEvents #Finale

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

Dave Feldman at #CoSci Las Vegas

100 Hearts.

@realDaveFeldman addressed the retraction of the LMHR Coronary Plaque Progression (CCTA) study and explained what led to that decision.

A candid look at the data, the analysis, and the reasoning behind pulling the paper, including a surprise twist later.
If you want the full story and where this research goes next, the conference recordings are worth it.
@realCSF

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

Dr. Shawn Baker at #CoSci, Las Vegas.
He says: joints need load.
Strength, full range of motion, progressive loading.
“Bouncing on a rebounder is not enough.”
@SBakerMD @realDaveFeldman @realCSF

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

Siobhan Huggins at CoSci, Las Vegas.

Lymphedema is a devastating and often lifelong side effect of cancer treatment.
Most of the effort goes into managing it after it appears.
Siobhan is asking a different question: could metabolic health before treatment change the risk?
Her hypothesis is that insulin resistance may play a role, and metabolic therapies such as ketogenic diets might help reduce that risk.

@siobhan_huggins @realDaveFeldman @realCSF

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

Louis Burns on stage at #CoSci Las Vegas.

All Models Are Wrong: Reconciling Carbs vs Calories

The carbs vs calories debate may exist because the two models explain different things.
Calories help explain body weight and composition.
Carbohydrates help explain metabolic health.
Both sides may be right, just talking about different problems.

@realDaveFeldman @realCSF

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

Jenna Ericson on stage at #CoSci Las Vegas.

Reactive Oxygen Species and Physiological Insulin Resistance

Her model: insulin resistance may begin in the mitochondria.
When excess electrons back up in the electron transport chain, reactive oxygen species are produced, which can blunt insulin signaling.
The fuel you burn may determine how much of that stress your cells generate.

@realDaveFeldman @realCSF

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

Dr. Stephen Hussey on stage at #CoSci Las Vegas.

Atherosclerosis: Are We Asking the Wrong Question?

For decades the focus has been on cholesterol, LDL, ApoB, Lp(a).
But plaque does not form in the bloodstream alone. It forms in a much more complex environment.
Dr. Hussey’s point: after decades of narrowing the question to lipids, maybe it is time to start asking different questions.

@DrStephenHussey @realCSF @realDaveFeldman

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

Emily Harari on stage at #CoSci, Las Vegas.

How to actually personalize medicine

Most lab reference ranges are built on population averages.
But none of us are the “average.”

Emily talks about microsampling. Small, simple blood samples people can collect at home and send in regularly.
The idea is to build your own baseline over time, instead of comparing yourself to a population range that may not fit you at all.
@realDaveFeldman @realCSF

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

Dr. Annette Bosworth on stage at CoSci, Las Vegas.

Sequenced Metabolic Repair

@AnnetteBosworth presents a striking case of severe metabolic dysfunction. Type 2 diabetes, prior cancer treatment, obesity, edema. HbA1c 10.9%. Triglycerides 547.

Standard approaches failed. Even a 21 day water fast did not produce meaningful ketosis. Two years of high dose tirzepatide had no effect.

Dr. Boz then shifted the strategy: repair metabolism first.
Nutritional ketosis to restore mitochondrial function, then reintroducing GLP-1 therapy at a tiny micro dose.

After 90 days: HbA1c down to 6.0%, 44 lbs lost, edema resolved, metabolic flexibility restored.

@realDaveFeldman @realCSF #CoSci

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

The Cholesterol Code documentary panel at CoSci, Las Vegas.

Following yesterday night’s screening at The Beverly Theatre.

Moderated by director Jennifer Isenhart, with Matt Baszucki, Robyn Dobbins, and Eric Rodgers, all featured in the film.

The conversation pulled back the curtain on the stories behind the documentary and the people whose experiences helped shape it.

@Metabolic_Mind @DrEricRodgers @matthewbaszucki @robynrdobbins @realCSF @realDaveFeldman

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

At #CoSci in Las Vegas @DominicDAgosti2

Brain Energy and Brain Injury: Considerations for Older Adults

We tend to associate traumatic brain injury with athletes or the military. In reality, it is most common in older adults.

After 65, even relatively small head impacts can have serious consequences.

Dr. D’Agostino framed brain injury as a problem of brain energy and resilience, not just the impact itself.

Protecting brain metabolism, maintaining strength and balance, and supporting metabolic health may reduce risk and improve recovery as we age.

@realDaveFeldman @realCSF

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

“I would have had to take that cocktail of meds for the rest of my life just to stay stable.”
Matt Baszucki at #CoSci

After years of manic psychosis, hospitalizations, and a bipolar diagnosis, he says ketogenic therapy changed everything.

“Once I fed my brain the right foods, everything fell into place. My manic episodes stopped.”

Now symptom-free after adopting a ketogenic diet under the care of @ChrisPalmerMD.

@janellison @Metabolic_Mind @realDaveFeldman @matthewbaszucki

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

Kicking off Day 3, the final day at CoSci.

Dr. Eric Westman: A review of the clinical research on keto diets. Where do we go from here?

Keto may be best known as a weight loss diet, but the research goes far beyond that.

Dr. Westman reviewed decades of clinical studies on low carb and ketogenic diets and looked at the evidence through an evidence based medicine lens.

The big question: where should the next generation of clinical research go?
@drericwestman @realDaveFeldman @realCSF

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

Dr. Ken Berry MD on stage at CoSci, Las Vegas.

“Never doubt that a small group of thoughtful, committed citizens can change the world; indeed, it’s the only thing that ever has.”
— Margaret Mead

Phase one is spreading the ideas.

The next step is becoming a foundational supporter.

That is how movements grow and reach more people.

@KenDBerryMD @Metabolic_Mind @TheSMHP @OfficialADSOrg

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

Dr. Nadir Ali on stage at CoSci, Las Vegas:

Statin trials often claim plaque “regression” based on coronary CT angiography (CCTA).

But small changes on CCTA are close to the limits of what the scan can reliably measure.

When you account for that noise, many trials actually show increases in coronary calcium and plaque volume.

In other words, the data often looks more like plaque progression than regression.

@eatmostlyfatali @realCSF

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

Craig Emmerich on stage at CoSci, Las Vegas:

Lipotoxicity and glucotoxicity are not separate problems. They are two sides of the same coin: energy toxicity.

When glycogen and fat storage are full, excess fuel spills into the liver, pancreas, muscle, and bloodstream.

That overflow drives insulin resistance, rising triglycerides, and chronically elevated fasting insulin, often long before glucose rises.

The key concept: the personal fat threshold. Metabolic disease is not just about body weight, but where excess energy ends up.

@emmerich_craig @realCSF

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

Beth Zupec-Kania on stage at CoSci, Las Vegas:

Menopause often brings rising insulin resistance as estrogen declines.

Beth shared her own story. At 50, she adopted a ketogenic diet and added moderate exercise.

Hot flashes resolved. Sleep improved. Glucose and insulin normalized.

Seventeen years later: strong metabolic health, no osteoporosis, no HRT.

Menopause is a metabolic transition. Lifestyle can change the trajectory.

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

Cynthia Thurlow: The Menopause Gut – The Microbiome as a Regulator of Aging in Women
CoSci, Las Vegas.

Perimenopause and menopause are not just a hormone story. The gut microbiome is part of the equation.

Hormonal shifts can change the microbiome, and the microbiome can influence how those hormonal changes are experienced. That may help explain why some women continue to struggle with symptoms despite standard approaches.

Supporting gut health, along with lifestyle measures and when appropriate HRT, may be an important piece of improving outcomes for women in midlife.
@_CynthiaThurlow @realDaveFeldman @realCSF

[Roxana Soetebeer, MPHC NNP MHP PFC @REV_Insulin_Res]

At CoSci Las Vegas: the LMHR panel with Dr. Nadir Ali, Dr. Nick Norwitz, Dr. Bret Scher, and Dave Feldman.

The Lean Mass Hyper Responder phenotype has become one of the most debated topics in metabolic health. These are people who are metabolically healthy on low carb or ketogenic diets, yet show very high LDL, alongside high HDL and low triglycerides.

That pattern does not fit the traditional cardiovascular risk model, which is why it has sparked so much discussion.

The panel looks at the emerging research, clinical observations, and what LMHRs might mean for how we think about cholesterol, metabolism, and cardiovascular risk.
@realDaveFeldman @bschermd @eatmostlyfatali @nicknorwitz @realCSF