Chris Larsen

Renal pathologist, researcher, and leader @arkanalabs

[Chris Larsen @renalpathdoc]

Had a great conversation with Dr. Irfan Agha about navigating glomerulonephritis: from diagnosis to emerging approaches in care and why close collaboration between nephrologists and pathologists matters so much for patients.
https://t.co/x55Pa8CWdO

[Chris Larsen @renalpathdoc]

I learned so much from this podcast. I encourage you to share it with your colleagues who are wanting to improve their renal biopsy technique!
https://t.co/Z833V4r1gf

[Chris Larsen @renalpathdoc]

@arkanalabs @shary_tang Sorry for the delay in responding! Nephrotic-range proteinuria is present in 10% to 26% of cases.
https://t.co/OHfv89BM0G

[Chris Larsen @renalpathdoc]

The amazing @Tiff_Caza educating us on NELL1 membranous!

[Chris Larsen @renalpathdoc]

Great job @MolenOdia and @nephrosharma on the presentation of ‘Machine Learning Classification of Kidney Biopsy Smartphone Images for Adequacy Assessment’. I look forward to seeing where this goes!
https://t.co/7hmnXJJ4rf

[Chris Larsen @renalpathdoc]

@lochon77 @arkanalabs A patient with clinical nephrotic syndrome and tip variant on biopsy should be considered to have a primary podocytopathy.

[Chris Larsen @renalpathdoc]

Quick teaching on the characteristic IgG staining pattern seen in anti-LRP2 nephropathy/ABBA. Enjoy!
https://t.co/glLrmJmo5r

[Chris Larsen @renalpathdoc]

@BJegorovic @arkanalabs @set_fortess Infection was quite rare in these GIN case series. Tb belongs in the differential though. The series below includes 17 pts with M. tuberculosis and renal biopsy. 16/17 had GIN on biopsy with caseating granulomata in only 3/16. 0/17 were pos for AFB.
https://t.co/zZi4P4EXKl

[Chris Larsen @renalpathdoc]

@VrushaliPatho @arkanalabs I have always found the approach of Nasr, et al helpful.... "a ratio of calcium oxalate deposits per glomerulus was calculated. The mean and median number of calcium oxalate deposits per glomerulus was 3.5 and 3.1 (range 1.5 to 7.9)."
https://t.co/igXVHrdhMg

[Chris Larsen @renalpathdoc]

@jesperkers 🤔 not sure. I suspect it is negative since these are composed of light chains but I did not check.

[Chris Larsen @renalpathdoc]

The morphologic spectrum of light chain proximal tubulopathy (LCPT). https://t.co/9tRJ2cF7Tf

[Chris Larsen @renalpathdoc]

Quick case-based teaching on the active lesions of ANCA including medullary angiitis and necrobiotic granulomas. https://t.co/1UWgiMWIB0

[Chris Larsen @renalpathdoc]

I have an interesting transplant biopsy with a great teaching point. Enjoy! https://t.co/3LqK273bG2

[Chris Larsen @renalpathdoc]

Continuing with the theme of genetic tubulointerstitial diseases that can be seen on biopsy. Enjoy!
https://t.co/NmIuZ4o9QN

[Chris Larsen @renalpathdoc]

@BajinderR @arkanalabs No, I have not seen anything specific at all. I'll try to cover that in a future episode!

[Chris Larsen @renalpathdoc]

Trying out something new here... Here is a quick teaching point from @arkanalabs to you! https://t.co/iH8pHJyO22

[Chris Larsen @renalpathdoc]

@BajinderR @arkanalabs A pathogenic variant was identified.

[Chris Larsen @renalpathdoc]

Ever wonder what to look for in uromodulin storage disease? Find out in this quick teaching point from @arkanalabs! https://t.co/375Ai2ZMNM

[Chris Larsen @renalpathdoc]

@DrGeetikaSingh1 @NephBean @MPAlexanderMD @SethiRenalPath @Richard @nephrosharma I usually only count as a percentage of intact glomeruli too. I think of this as a measure of activity and a globally sclerotic glomerulus cannot have an active crescent. As such, it does not make sense to me to use it in the denominator.

[Chris Larsen @renalpathdoc]

Love this!

https://t.co/SX61PON0Uj

[Roger Rodby @NephRodby]

@arkanalabs @VertexPharma "Hypertensive nephrosclerosis" (HTN-NS), move over, there's a new sheriff in town: APOL1 mediated renal disease. Its about time we move into the 21st century. Testimg just got a lot easier. RIP HTN-NS