Robert Gilchrist

Prof and NHMRC Fellow at UNSW, Sydney; Head Oocyte Biology Research Unit; Director of Research, SWCH; oocyte and reproductive biologist

[Robert Gilchrist @RG_EggLab]

Thanks Claire. Lots of ups and downs along the way but it has been worth it

[Claire Roberts @clairetroberts]

Wow! I remember when this was your dream Rob People don’t have a clue about how hard it is to get our great science from bench to bedside Congratulations!🙌

[Lindsay Wu @LindsayWu_UNSW]

Grateful for this lovely writeup of our work on chemo induced infertility in @EmboMolMed! Many thanks to @norahspears @AgnesStefansd and Adomas Liugaila

Can we manipulate the ovary’s own metabolism to protect it from chemotherapy-induced damage? https://t.co/3TNWhlIbzg

[Robert Gilchrist @RG_EggLab]

Hormone-free infertility treatment....well, here we are finally...it's a clinical reality!! 20 years ago, our old IVM alliance: myself, @jeremygthompso2, Johan Smitz and @MdevosMD made this our aspirational goal. Now Dr Lan Vuong and @TuongMHo got there!!

[Robert Gilchrist @RG_EggLab]

Super article that one…ha ha 😁😁

[Reproduction journal @ReprodJournal]

New #openaccess review published as part of the Reproductive Ageing collection:

'Reproductive Ageing: Metabolic contribution to age-related chromosome missegregation in mammalian oocytes' by Bettina P Mihalas et al.

Read it here: https://t.co/HCsHcg7Giv

[Robert Gilchrist @RG_EggLab]

Collectively about 60 years of pre-IVM research right there @AlbertoMLuciano @redbiolab @SSRepro

[ReDBioLab @redbiolab]

Some few more pictures that need to de shared #Ssr2024 @SSRepro
@AlbertoMLuciano @RG_EggLab #Johan_Smitz @ufpjhansen @Federic37835007 @GiuliaMusmeci55 @MarcSirard @masroorsagheer2

[Robert Gilchrist @RG_EggLab]

What an achievement from @TuongMHo and the @research_hope , completely hormone-free ART with good pregnancy outcomes. Only possible with an advanced IVM system. Awesome - we have been waiting a long time to get to this point. Congrats!!

[Tuong M Ho @TuongMHo]

Hormone-free ART for PCOS women | Presented at ESHRE 2024 to a large audience.
It is feasible and efficient. Single blastocyst transfer with good pregnancy outcome.

[Michel De Vos @MdevosMD]

Interested in IVM in hyperresponders? 👉 Check our poster on (cori)follitropin priming of antral follicles and the impact on oocyte yield and pregnancy rates #ESHRE2024 @BrusselsIVF @UZBrussel @ESHRE

[Robert Gilchrist @RG_EggLab]

@HillLabSask That is super interesting from many different perspectives, not least how important post-grad students are to a lab

[Robert Gilchrist @RG_EggLab]

fantastic work @TuongMHo @research_hope . OTO-IVM (ex vivo IVM; immature oocytes from ovarian tissue) is a no-brainer for fertility preservation for a lab routinely running IVM for infertility treatment. Easy peasy !!

[Tuong M Ho @TuongMHo]

OTO & CAPA IVM | We retrieved immature oocytes from ovarian tissue, applied biphasic IVM. We got 22 MII oocytes for vitrification in this case. Really potential !

[Robert Gilchrist @RG_EggLab]

@PepinLab @NatGeo @NUDuncanLab Can't get to it - National Geographic subscribers only 🫤

[Robert Gilchrist @RG_EggLab]

Ask the Experts - what is IVM? https://t.co/z34KmqTw1N via @YouTube

[Robert Gilchrist @RG_EggLab]

This is what mastery of IVM looks like #ESHREjc and with zero patient stimulation!

[Tuong M Ho @TuongMHo]

Another day of IVM in December last year and results.
All four were PCO women, without stimulation before OPU.

[Robert Gilchrist @RG_EggLab]

Wow..!! Zero stimulation ART is a thing! This is what can be achieved when you have an excellent quality and very experienced IVM clinic. Congrats @TuongMHo and @research_hope

[Tuong M Ho @TuongMHo]

Why stimulation for PCO women?
Today we have 4 cases of IVM for PCO. We collected at least 20 oocytes each, without any gonadotropin priming. Our maturation rate is > 60%. > 90% of our IVM cases have blastocysts for transfers.

[Robert Gilchrist @RG_EggLab]

@SofiaMakieva @FlorSR5 @OmarRawi89 @VuongThiNgocLan @krammecc @SofiaMakieva oocytes from older women definitely need help, regardless whether IVM or COS-IVF oocytes. But how and with what is the million $$ question, right? In theory IVM could provide an opportunity for treatment that COS-IVF does not. But no silver bullet yet. #ESHREjc

[Flor Sánchez @FlorSR5]

@SofiaMakieva @OmarRawi89 @VuongThiNgocLan @krammecc Good question … An inverse relationship between the oocyte developmental status at collection and the length of pre-IVM culture has been hypothesized (Gilchrist et al. 2024) @RG_EggLab. Oocyte developmental status depends on gonadotropin (dose) priming, follicle size. #ESHREjc

[Robert Gilchrist @RG_EggLab]

@SofiaMakieva @FlorSR5 @OmarRawi89 @VuongThiNgocLan @krammecc Do you mean age of the patient? If so, it is identical to COS-ART: IVM success rates decline with maternal age and are poor by 40

[Tuong M Ho @TuongMHo]

@FlorSR5 @RG_EggLab @SofiaMakieva @krammecc @GLiperis @BortolettoMD @MdevosMD @VuongThiNgocLan @maclaudiaa @juanjo_fraire At least 10% IVF patients should not have ovarian stimulation, to get enough embryos for high accumulative live birth rate per OPU.

[Flor Sánchez @FlorSR5]

@SofiaMakieva @krammecc @GLiperis @BortolettoMD @RG_EggLab @MdevosMD @VuongThiNgocLan @maclaudiaa @juanjo_fraire I do not believe we should see IVM as replacing IVF. However IVM should be acknowledge for their advantages and should be considered as a complementary tool available for the treatment of a selected groups of patients (hyperresponders) within a conventional IVF program. #ESHREjc

[Robert Gilchrist @RG_EggLab]

@MdevosMD @SofiaMakieva @GLiperis @SofiaMakieva. High - no, abnormal - yes. Remember a naked GV oocyte is an abnormal oocyte. In vivo, at no stage are oocytes ever naked. CCs are the oocyte’s nurse cells. No one should be surprised aneuploid rates are higher with Rescue IVM. #ESHREjc