Francesco Ricci Lab

Professor @ Univ. of Rome Tor Vergata. #Nanotechnology, #SyntheticBiology, #Nanomachines and #Nanodevices.

[J. Am. Chem. Soc. @J_A_C_S]

Immune-Induced Antibody–DNA Hybrid Condensates | Journal of the American Chemical Society https://t.co/xUxQVzUaYJ

[Francesco Ricci Lab @RicciLab]

All results were nicely described by theory and simulations of a phase-field model by our collaborators Lorenzo Rovigatti and Marco Cappa @SapienzaRoma. Finally thanks to co-corresp author
@erica_delgrosso for her invaluable support and @AIRC_it and @ERC_Research for funding. 6/n

[Francesco Ricci Lab @RicciLab]

New paper from our group just out in @J_A_C_S! We show the combined use of DNA-DNA and antibody–antigen interactions to induce phase separation of antibody–DNA hybrid condensates. https://t.co/j8wpPiDH2J Congrats to Sara (@sara29_ss) for her first first-author paper!👇🧵 1/n

[Francesco Ricci Lab @RicciLab]

We also show that by simply replacing the antigen on the DNA nanostar we can induce the phase separation of different condensates in a orthogonal way without any crosstalk...here is the microscopy image of three condensates formed upon addition of three different antibodies! 5/n

[Francesco Ricci Lab @RicciLab]

All places have been filled!

[Francesco Ricci Lab @RicciLab]

The next Functional DNA Nanotechnology workshop #FDN2025 (Rome 15-17 October) is just around the corner! Due to last minute cancellations, we still have a couple of places available if anyone is interested... https://t.co/0wMP4Zx8ZX

[Francesco Ricci Lab @RicciLab]

Nice to see this collaborative work out in @angew_chem. We joined forces with @Ale_Sorrenti1 and @PuigmartiLuis to achieve non-equilibrium steady states using DNA-based systems and controlled RNA fuel supply. Congrats to @erica_delgrosso and @JamesDNicholas🥳

[Alessandro Sorrenti @Ale_Sorrenti1]

📢Check out our new paper! ✨
We demonstrate non-equilibrium steady states of a DNA-based system that dynamically adapt in real-time to subtle on-the-fly variations of a RNA fuel supply, and correspond to a true non-equilibrium composition of the system.
https://t.co/8VF5C5gJdx

[Erica Del Grosso @erica_delgrosso]

Excited to see our latest work finally out in @NatureNano 😍😍. Great collaboration and many thanks to all the authors @leonard_prins @RicciLab @benjamino_acid and @Epenocchio 🥳🥳

[Francesco Ricci Lab @RicciLab]

Great to see this is now out in @NatureNano! Thanks to @leonard_prins for this (yet another) collaborative project...kudos to @erica_delgrosso and Ben Roberts for combining experiment and theory in such a nice way. Thanks also to @EPenocchio for help with the theoretical part!

[Nature Nanotechnology @NatureNano]

New paper online:

An information ratchet improves selectivity in molecular recognition under non-equilibrium conditions.

"...mechanism increases selectivity for the correct DNA duplex from 2:1 at equilibrium to 6:1 under energy-dissipating conditions."

https://t.co/EOCUAmFHRu

[Francesco Ricci Lab @RicciLab]

Hurry up! Today is the deadline to submit an abstract for the next Functional DNA Nanotechnology workshop #FDN2025, Rome 15-17 October 2025! Co-organized with Tim Liedl (@CeNS_LMU) and Fritz Simmel. https://t.co/KjmEci8ASG

[Francesco Ricci Lab @RicciLab]

@rjerala Very nice! Coupling the programmability of nucleic acids with the versatility of proteins might indeed become a game changer for many applications...

[Francesco Ricci Lab @RicciLab]

Finally, big congrats to our PhD student Francesca Miceli for her first first-author paper and to all the coauthors (@Simona_Ranallo, @BracagliaSara, @SorrentinoDa, @alessan_porch).

[Francesco Ricci Lab @RicciLab]

The paper describing our MAIGRET (Molecular Assay based on antibody-Induced Guide-RNA Enzymatic Transcription) system is finally out in @NAR_Open! https://t.co/JzlIcq9SZP. @ERC_Research, @AIRC_it 1/n

[Francesco Ricci Lab @RicciLab]

The name of the assay is an homage to one of the best examples of CRISPR-based sensors (SHERLOCK,
@Sherlock_Bio) developed by @zhangf, Collins + colleagues. While SHERLOCK detects DNA/RNA strands, MAIGRET enables the detection of proteins, antibodies and other molecules. 5/n