Andrey Los 🇺🇦🇵🇱🇪🇺

Ex-@perplexity_ai, ex-Revolut, YC Alumni (W21). In ❤️ with singing, coding, games, padel (not gay) Formula 1. Opinions my own.

eu/acc, pro federal EU

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

Yet another upgrade of my sim racing setup :) Need to add some bass shakers and maybe button boxes and it will be done. Not sure about done tho, it's never ending story :D

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

@rasmus1610 @thekitze They're useful with human judgement :) But in an automated setting, they require a lot of babysitting still :)

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

@rasmus1610 @thekitze @thekitze you liked my post but I saw no reaction to my Lip A posts :( Were they useless? :(
:D

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

@rasmus1610 @thekitze Still in papers on ML models that trained on scans performed better than human radiologists. Unsure if general purpose model is actually as good as special purpose one used in clinical setting.

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

@Kerry_Shark С Днем Рождения! Офигенно выглядишь. В жизни бы не сказал, что тебе 42!

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

Funnily enough today I entered a public restroom with such type of the toilet, and saw pile of shit right at the edge of it :D (like bottom left picture)
So, this instruction isn't as useless a sit seems. If they can read :D

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

Apparently you need instructions to know how to shit :D

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

@JoshuaBarzon What's the app?

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

@grok @thekitze Proud of myslef 😎

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

@maciekChmura @thekitze It's genetic and might be as low as 5 :)

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

@thekitze Mine lip (a) is 12. Apo B 56 dl/mg, LDL 1.87 mmol/L (72 mg/dL).
Getting to 40 and 60 is around the corner (already taking Izetemibe, asking friends to deliver from Ukraine without a recipe every couple of months :P)

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

Supplements to start:
- Psyllum Husk 10g daily (2 hrs before or after any other supplements)
- Berberine 500mg (up to 1g, consult Claude)
Prescription medicine:
- Izetemibe 10mg (near zero side effects, great profile)

Measure in 6 months Apo B, LDL.

If you get them below 40 and 60 dl/mg respectively, you're golden and near zero lifetime risk. If you get them below to 30, and 40, you're basically immune to plague.

If you're still up high 80, 110 respectively or so, then start 5mg statins on top (all above stacking nicely), but try not to go higher than 10mg ever as then you get diminishing returns, with much higher chances of side effects.

Then wait 5 years till PCSK9 gene knockout medicine is generally available globally, and use it to get to elite levels without all the above. There are studies already of such medicine using CRISPR. So it's really around the corner.

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

The problem with these studies is that they’re very short, as far as I know. The effects of lowering lipoprotein levels only become apparent over the long term—10, 20, or 30 years. So a short-term reduction in lipoprotein A levels today won’t make much difference over the next 2-3 years, especially for people who have already developed cardiovascular problems. So even though these studies failed, that doesn’t necessarily mean they’re useless. We just need to observe people for longer on these drugs and use them early and see how it will affect mortality and heart events later.

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

Low dose statins + izetimibe. Highest yield is up to 10mg anyway AFAIR, so going past is diminishing returns if we contrast it against the probability of side effects.

In order: active lifestyle (4-5 workouts a week), diet, supplements, sauna (before problems occurred), izetimibe, low dose statins.

Cannot wait for gene editing tho, to completely solve this problem.

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

@EU_Eurostat Do it by net salary and then adjusted to PPP. And then we're talking of somewhat useful metric.

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

@levelsio Some of them. Thankfully, I haven't met a single fund with that attitude in Europe. They were retarded in other ways tho :D

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

@nestymee Just shows that if there is a goal, there is a way to get there :)
Like, when you really try to get there (fake "goals" doesn't count)

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

Same but for IDEA. Was paying for it for 10 years... Haven't renewed my subscription for 2027.

Sad, but it's what it is. I hope they'll survive this new world somehow. Air is too late IMO.
It's nice and all, but it should be superior to Open Source tools like https://t.co/HIVMucbuSK and https://t.co/UWu7wLioCd

[Andrey Los 🇺🇦🇵🇱🇪🇺 @rip212]

@boardyai @EWOR_official @andreasklinger @pettermade