rishub

founding engineer @plasmidsaurus | prev. bioinformatics @alloytx, med device founder

[Niko McCarty. @NikoMcCarty]

My first podcast is out today with @markwbudde, CEO of @plasmidsaurus.

Plasmidsaurus took whole-plasmid sequencing from $600 to $15 and turned a "boring" service company idea into a hugely successful company that now serves >70,000 scientists.

We talked about what it means to build a "boring" company, whether the Plasmidsaurus idea could apply to other technologies (like CRISPR screens), and why Plasmidsaurus isn't expanding into China. This podcast is made possible by @AsteraInstitute.

00:00 – Enter Plasmidsaurus
01:21 – Reducing sequencing costs by 40x
04:17 – Scaling Oxford Nanopore technology
06:29 – Venture capital and building a "boring" company
13:03 – Plasmidsaurus vs. traditional CROs
22:25 – On selling customer data
30:10 – Building a moat
37:08 – 50-minute results
39:26 – Logistics and the UPS partnership
48:42 – The Chinese market
50:20 – Playbook for new biotech founders
52:31 – The future of biological reasoning and AI

You can find the podcast, THE NEW BIOLOGY, on YouTube, Spotify, and everywhere else.

[Seth Bannon @sethbannon]

In a couple years this will be seen as a before and after moment for bio. @plasmidsaurus enabling everyone to get good transcriptomics in days will change the way research is done.

[plasmidsaurus @plasmidsaurus]

🦖 Something HUGE just hatched.

Plasmidsaurus now offers RNA sequencing for gene expression analysis with:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results that let you explore changes in genes and pathways

Explore Plasmidsaurus RNA-Seq today.

[rishub @rishub_handa]

@ATinyGreenCell @markwbudde We actually just developed a prototype BLAST feature for your library. I'll turn that on for you

[Sebastian S. Cocioba🪄🌷 @ATinyGreenCell]

New @plasmidsaurus basepair visualizer looks good on mobile! I got my RFP plant expression circuit too. Next week gonna clone into pCambia2300 and then first test in Alice.

[Sebastian S. Cocioba🪄🌷 @ATinyGreenCell]

I love waking up to @plasmidsaurus results. My GFP and RFP petunia constructs are confirmed! Now to shove them into agrobacterium. Petal tests next week!

[plasmidsaurus @plasmidsaurus]

Hey dinos 🦖 we’ve been cooking up something new in your library…

Now you can:
1. Quickly align any two sequences from your history or uploads
2. Search across everything you've sequenced with us

We'd love a few of you to try early access & help build this. Reply if you're in!

[plasmidsaurus @plasmidsaurus]

We're heading to ASM next week!

Come find us at Booth 1241 to check out our new microbiome and bacterial genome sequencing services—and pick up some fun dino swag while you're there! 🦖🎁

[plasmidsaurus @plasmidsaurus]

Wait, you’re still doing minipreps? 💀 Use ZeroPrep to go straight from colony to whole plasmid sequence, overnight. Now supporting low-copy plasmids — so you can save time, reduce labor, and tackle constructs.

Start sequencing our improved service now: https://t.co/fv1Ubo7RiQ

[plasmidsaurus @plasmidsaurus]

We collected our DNA Day mystery swabs at 11am, extracted the DNA, then carried out our 16S Amplification service and sequenced, all before 4pm same day.

We won't make your samples wait, either. Any surprises in these Genus-level results? (1/5)

[plasmidsaurus @plasmidsaurus]

Ski fast…and sequence faster. Plasmidsaurus now lives in Germany! 🇩🇪

Overnight sequencing for ALL of Europe
Pickup ~4PM → Results 8AM

🦖 Dropboxes in 14 European countries...and the dino is looking for MORE! Request your free dropbox here: https://t.co/O7b20zz8fP

Sequence plasmids, amplicons, bacteria, libraries, yeast, AAV, microbiomes, eukaryotes…sequence everything. No primers needed.

Big love to Dr Jan Müller, PI at the Medical University Innsbruck, Austria, for starring in this video!

[plasmidsaurus @plasmidsaurus]

We’re piloting a new way to compare your samples to a reference.

We automatically handle alignment and highlight differences—right on the results page. No need to mess around by hand.

DM us to try it out! 📥

[plasmidsaurus @plasmidsaurus]

New at Plasmidsaurus: Microbiome sequencing without the wait

Full-length 16S, 18S, and ITS amplicons — results in 1-2 days.

[plasmidsaurus @plasmidsaurus]

New feature drop: You can now compare sequences to a reference right from the results page—just drag and drop your files and get your answer in seconds.

No extra steps, just results.

(Video demo below👇)

[plasmidsaurus @plasmidsaurus]

We got you covered

[plasmidsaurus @plasmidsaurus]

New update: Promoters and origins of replication are now easier to spot in your results summary!

No more guessing—just clear, intuitive visualizations.

[plasmidsaurus @plasmidsaurus]

No more clicking around—your DNA sequences now appear directly in your results email. See if your experiment worked straight from your inbox 📧

[plasmidsaurus @plasmidsaurus]

Last week, we gave you a sneak peek—now it’s live! 🎉 Explore the new Plasmidsaurus Library and find your plasmids faster: https://t.co/kxFYWWCENy

[plasmidsaurus @plasmidsaurus]

We're building a new tool—search your plasmids by feature, sample name, and more. Plus, favorite the ones you use most. Tracking your work across experiments is about to get a whole lot easier.

Stay tuned!🔍

[rishub @rishub_handa]

@koeng101 @plasmidsaurus Some example code snippets to get started are here https://t.co/8tq92qrwgp

We’ll flush this out in the coming weeks :)