🧵 New paper out in @JNeurosci! We found an unexpected source of histamine in the developing brain — and it may help explain Tourette's & OCD. A thread 👇
Congratulations to Naia Marcelino for concluding a very successful vist with the team at @OxfordDPAG
Naia became an expert in striatal pathways and contributed to develop new technologies to create a mini-striatum with hiPSCs. Very well done! @WadeMartinsLab@SPC_Oxford
🧵 New paper out in @JNeurosci! We found an unexpected source of histamine in the developing brain — and it may help explain Tourette's & OCD. A thread 👇
5/ WHY IT MATTERS 🧠
This reframes how we think about histamine signalling: it acts as a *paracrine* neuromodulator, crossing anatomical boundaries. With BNST-DBS already showing efficacy in OCD, histamine release may contribute to its rapid therapeutic effects.
A few years back, Ricardo (@rmargoneuro) and I envisioned a way to turn the spontaneous, cross-disciplinary conversations of #Oxford researchers into something more enduring, a framework that could help those everyday ideas evolve into real, tangible collaborations.
Interdisciplinary collaboration is at the core of technology development.
Hence, we developed #CrossLinks a program tailored to @StCrossCollege to transform ideas into tangible outcomes.
Check it out and support the fundraising!
https://t.co/Re4DFrw0Yq
Our second edition of the Histamine Receptors book is out as e-book! We contributed with an updated chapter on histamine H3 receptors modulation of neurotransmitter release in the Basal Ganglia and Nucleus Accumbens.
Check it out and reach out!
https://t.co/CVFSuu1ELk
Had a chat with ASAP about the fluid-wall technology that we are using to generate reliable neuronal circuits on-a-dish to study #Parkinson. Read more on https://t.co/MobjB35Bwy
https://t.co/Rte1IBE3gH
PhD star Oliver Curry giving a great invited talk at Development of Dopaminergic System Symposium on generating fast-printed and miniaturizad #organoids to study #Parkinson. First congress, first invited talk, fantastic work! @OxfordDPAG@OxfordChemistry@WadeMartinsLab
NEWS: Oxford biologists and engineers awarded £2 million to grow human neurons as brain circuits in chambers made of oil
Researchers from @OxfordDPAG and the Dept of Engineering will study the physiology, regulation and cellular architecture of neurons.
https://t.co/InBfzlJFVN
Couple weeks ago @AishwaryaVedul passed her PhD transfer with flying colours! Congratulations Ash! Setting a solid direction for her PhD, researching purinergic signalling in hiPSCs and mouse models @OxfordDPAG@WadeMartinsLab@StephCragg
My PhD Ollie Curry is fundraising for Parkinson’s UK. Check out their @JustGiving page and please donate if you can. Thank you! #JustGiving https://t.co/dBTub99sVh
Join us today (19 August) at 2pm (Europe/London) to hear from #OpenBiology author Asami Oguro-Ando on her article, CNTN4 modulates neural elongation through interplay with APP, chaired by @rmargoneuro https://t.co/uxFatCxkI9 #neuroscience
Coming up next week - 19 August at 2pm (Europe/London), join us to hear from #OpenBiology author Asami Oguro-Ando on her article, CNTN4 modulates neural elongation through interplay with APP, chaired by @rmargoneuro https://t.co/8wTZDxfr3b #neuroscience
Hi all! I'll be chairing a seminar with @RSocPublishing to chat about the recently published paper about the involvement of cell adhesion molecule contactin-4 in #Alzheimers.
Join us on 19 August :)
https://t.co/vs8BJvDmTS