Rohit Roy

Postdoc @ MRC LMB

[Cell @CellCellPress]

In the latest issue! Thermodynamic prediction of RNA cellular activity from sequence via conformational ensembles https://t.co/gxEkeVsetl

[NatureStructMolBiol @NatureSMB]

New online! Predicting RNA cellular activity https://t.co/NXx7VWto1f

[Cell @CellCellPress]

Now online! Thermodynamic prediction of RNA cellular activity from sequence via conformational ensembles https://t.co/xPHvcyrzwG

[Rohit Roy @rroy97]

Associated press release:
https://t.co/6W7yYIHDpr

[Rohit Roy @rroy97]

Excited to share my final PhD work from the Al-Hashimi lab at @Columbia titled “Thermodynamic prediction of RNA cellular activity from sequence via conformational ensembles” is now out in Cell @CellCellPress:
https://t.co/rnPhtbJqRU

[Rohit Roy @rroy97]

Working with my amazing lab mate @GengAinan, we used NMR combined with binding & cellular measurements to show that conformational ensembles provide the energetic link to go from RNA sequence to cellular activity using existing RNA secondary structure prediction tools.

[J. Am. Chem. Soc. @J_A_C_S]

Kinetic Dissection of Proton-Coupled Conformational Transitions in Nucleic Acids by Integrating pH-Dependent NMR and Chemical Modifications | Journal of the American Chemical Society @Columbia https://t.co/cG5nsd1yKS

[Or Szekely @OrSzekely]

Our paper is out in @NAR_Open !
https://t.co/W3ZFX84wBu

[Or Szekely @OrSzekely]

A fantastic paper about the conformational ensemble of an invisible state of RNA! By the amazing @GengAinan! https://t.co/IRoP1BJtcL

[Rohit Roy @rroy97]

Cool new work from the lab, led by @GengAinan looking at the structure of an “invisible” RNA conformational state enriched in mismatches! https://t.co/GWKJltAWrn

[Rohit Roy @rroy97]

rendered movie depicting these resolved conformational states

[Rohit Roy @rroy97]

Excited to have our work on resolving conformational states in RNA ensembles using NMR out in JACS!

[J. Am. Chem. Soc. @J_A_C_S]

Kinetic Resolution of the Atomic 3D Structures Formed by Ground and Excited Conformational States in an RNA Dynamic Ensemble | Journal of the American Chemical Society @Columbia #Structure #RNA #Dynamics #ExcitedState #Conformation https://t.co/fqbbEByATZ

[Or Szekely @OrSzekely]

1/ Negative is also positive! Our new study shows that mismatches in RNA:DNA hybrids can adopt a negative charge and have a substantial effect on fidelity of biochemical processes, such as transcription, translation and CRISPR/Cas9 off-target gene editing!
https://t.co/twDD0w0Uon

[Rohit Roy @rroy97]

Cool new PNAS perspective from my advisor Hashim Al-Hashimi on describing biological systems as computational machines, titled: Turing, von Neumann, and the computational architecture of biological machines | PNAS https://t.co/FYVhPNUUrw

[Megan Ken MD PhD @Magnetic_Megan]

It's been a week folks! The project that defined my PhD has been published today in @Nature: https://t.co/AAZEJ8tEyW. Congrats to everyone involved in this work and a huge thank you to Hashim and Dan for their mentorship!! Also, my name is not a typo ! 1/2

[MS NOW @MSNOWNews]

BREAKING: Twitter says it has "permanently suspended" President Trump's account "due to the risk of further incitement of violence."

[Biophysical Society @BiophysicalSoc]

Hashim Al-Hashimi has been named a 2021 Fellow of the Biophysical Society https://t.co/oGc7OupQiK