Excited to see this one out. https://t.co/6DQpx1KIFt. Estrogen muzzles microtubules to protect the RV! Huge thanks to @TimLahm for helping use get this one across the line! @jclinicalinvest made this a wonderful experience! @ResearchMUSC@MUSC_Cardiology
Congratulations to @MUSChealth cardiologist & physician-scientist @kurt_prins on his election to the prestigious American Society for Clinical Investigation. He is the 1st MUSC physician-scientist elected since 2014. Learn more: https://t.co/E3YSEhW86H
Do you want to know the cellular and molecular determinant of progressive RV dysfunction? @Jenna_Mendelson caps off her PhD thesis to define them in a porcine model: https://t.co/yeE9dJfKJv
My thesis paper is out in @CircRes! We did a little bit of everything in this one: single-nucleus RNA seq, electron/confocal microscopy, proteomics, metabolomics, lipidomics - all in large animals to show how GP130 antagonism improves RV function in pigs. https://t.co/HcGLUblGsk
Led my @MadelynJBlake, our latest pre-print in which we performed a multi-tissue, multi-omic, multi-species, and multi-continent evaluation of BCAA metabolism in PAH and liver dysfunction. @ResearchMUSC@MUSC_Cardiology@MUSC_COM https://t.co/VOx0yyrmSu.
New work from MUSC Gazes Cardiac Research Institute Director @kurt_prins defines a multi-omic signature of skeletal muscle dysfunction in PAH. https://t.co/gyI4EeXWCo
Thank you @CircHF for the opportunity to share our work on how modulating the gut microbiome may be an approach to enhance RV function in PAH. Grateful to the entire research team for their help on this project. @ATS_PC@3CPRCouncil@PVRI @GiessenPh @RyanTedfordMD@GMFHx
Finally across the finish line! Excited to share with the community very soon @SashaPrisco's work showing modulating the micro/mycobiome with Lactobacillus has anti-inflammatory effects and combats rodent RV failure. @3CPRCouncil
Sex, drugs, and microtubules? Excited to share our latest preprint showing estrogen can exert cardioprotective effects by combatting microtubule densification in the failing RV. https://t.co/4o3kNB4IU9. @3CPRCouncil@UMN_IBP@LilleheiHrt#microtubules.
New article in Circulation by Drs. Kurt Prins and Sasha Prisco highlights a previously unknown function for protein junctophilin-2. (https://t.co/UoIU2ShJdB) #UMNresearch#UMNheart#UMNproud#Cardionerds
From the microbiome to the microtubules: Latest preprint led by @SashaPrisco showing the anti-inflammatory bacteria Lactobacillus can counteract systemic inflammation-associated microtubule remodeling in RV failure. https://t.co/TgknZp2Z5B @3CPRCouncil@PVRI@UMNresearch