How should we be drugging RAS and developing clinical combinations for RAS-driven tumors?
@andrewaguirremd, Alice Shaw, @Julien__Dilly, and I have a lot of thoughts (>15,000 words of thoughts), and our mega review is out now at @CD_AACR! Check it out: https://t.co/sUU5fzpM7f
Online now for the #AACR25 session on Advances in #KRAS Biology in PDAC by session speaker @andrewaguirremd: Response and Resistance to RAS inhibition in Cancer https://t.co/y2lwO3oXdz
Absolutely incredible to see the massive benefit of RAS inhibition in pancreatic cancer patients, changing the field as I finish my training!! Led by one of my clinical mentors, Brian Wolpin, and received with standing ovation.
Also very cool to be cited in the discussion :)
Incredible #ASCO26 moment.
Dr. Brian Wolpin, presenter of the daraxonrasib study, received a standing ovation DURING his talk after he stated the survival benefit for PDAC patients. It was sustained. Cheering. I have never see anything like it in the middle of a talk. $RVMD
A new standard for PDAC. Daraxonrasib with 13.2m OS in 2L, and next-generation molecules in development. #RAS
Incredible to see this field changing as I finish training.
Congrats to $RVMD, @NextechInvest + @schroederthilo, and to all the patients!!!
https://t.co/QSwHNJKJte
Happy to have contributed to this new work from @KathleenMulvan4 and @TheSellersLab, showing that KRAS and PRMT5 inhibitors synergy, out now in Cancer Research. KRAS/PRMT5 combos ($RVMD/$TNGX) are now in clinical trials, and results couldn't come sooner!
https://t.co/mIc6hkbMpL
The Trump administration has moved to terminate scores of research grants at Harvard University and its medical school, imperiling scores of research projects and potentially upending the futures of dozens of young scientists. https://t.co/PXz91lOI0v
@jmvyasmdphd@MGHMedicine@mghmedres Thank you @jmvyasmdphd for everything you’ve done for the residency, it was an incredible place to train during your tenure. Looking forward to seeing what you do next!
Beyond grateful to have had the opportunity to pursue residency at @MGHMedicine with the incredible mentors and coresidents at @mghmedres—so much growth and learning over the last few years.
Per my superlative, maybe one day I’ll put these lessons to use in my Ibiza-based lab 😂