Caner Akıl

[Caner Akıl @s49727]

Our study is out in Nature Communications!

[CAMS Oxford Institute @CAMS_COI_Ox]

New Publication: Unveiling structural determinants of peptide recognition by public and private SARS-CoV-2-specific T-cell receptors. https://t.co/tjuHUFGJZe
Fernandes Group:
https://t.co/XQCGGsFvEJ
Dong Group:
https://t.co/n0LWjpCoFs
Zhang Group:
https://t.co/lJajIDXlQ2

[Caner Akıl @s49727]

Our study is out in Nature Communications!

[the Peijun Zhang Lab @GroupZhang]

One viral target, different routes to recognition! Our study, now published in Nature Communications, reveals how distinct T-cell receptors recognise the same SARS-CoV-2 target. 🔗 https://t.co/TFRj4xFmRQ
@s49727
@OxfordStrubi
@TaoDongGroup

[the Peijun Zhang Lab @GroupZhang]

One viral target, different routes to recognition! Our study, now published in Nature Communications, reveals how distinct T-cell receptors recognise the same SARS-CoV-2 target. 🔗 https://t.co/TFRj4xFmRQ
@s49727
@OxfordStrubi
@TaoDongGroup

[bioRxiv Immunology @biorxiv_immuno]

Uncovering structural determinants of peptide recognition by public and private T-cell receptors https://t.co/I1fTDVGQ8n #biorxiv_immuno

[Caner Akıl @s49727]

Our study is out in Nature Communications! 🎉

We reveal the full sequence of SARS-CoV-2 spike-mediated membrane fusion & show how S2-targeting antibodies block it using cryoET in a near-native system.

🔬🦠 https://t.co/W0aV8gjgsv

#SARSCoV2 #CryoET #Virology #CryoEM #Antibodies

[Caner Akıl @s49727]

Interestingly, upon interacting with the ACE2 receptor dimer, spikes cluster at membrane interfaces and, following S2' cleavage, transition concurrently to postfusion conformations—encircling the hemifusion and pre-fusion pores in a distinct conical arrangement.

[Caner Akıl @s49727]

Excited to share our study capturing complete fusion event snapshots of SARS-CoV-2 and its inhibition by the S2 antibody WS6 via in situ cryo-ET under near-native conditions🦠.
Big thanks to Jialu Xu, Juan Shen, and Peijun Zhang.
#CryoET #SARSCoV2 #CryoEM
https://t.co/muX9kGeYK8

[Astrobiology @astrobiology]

Early Ocean World Chemistry: Prebiotic Nucleoside Phosphorylation in a Simulated Deep-Sea Supercritical Carbon Dioxide-Water Two-Phase Environment
https://t.co/rIUSmtckn3 #astrobiology #biochemistry #genomics #originoflife

[Caner Akıl @s49727]

@esrabalikci10 Tremendous effort by Esra Balikci-Akil et al.