Check out our (+ @sabobillo@CwynKate) review on #CNSprophylaxis in this year's educational book
https://t.co/3eq1rMVIZ6
To be presented by @CwynKate in Controversies in Aggressive NHL educational session Sat 9.30
A pleasure to work with @sabobillo @JahanzaibKhwaja & #AndresFerreri on our review of ‘Prevention and Management of secondary CNS lymphoma’
A challenging & contentious area with still much to do to improve outcome for our patients
#lymsm https://t.co/1hKsDyOgAU
Our @SWOG analysis of extranodal presentation in limited-stage DLBCL, demonstrating similar outcomes to nodal presentations when treated with response-adapted therapy. @DebbieMStephens@DrDanPersky https://t.co/NkXTHjn3b2
Review/meta-analysis:
#CAR -T in #PCNSL n=30 & #SCNSL n=98.
SIM CRS/ICANS.
PCNSL vs SCNSL:
70% vs 72% CRS any grade
13% vs 11% grade 3-4
53% vs 48% ICANS any grade
18% vs 26% grade 3-4
SIM RESPONSE:
56% vs 47% CR
37% for both in remission at 6/12
#lymsm https://t.co/W7KaERzaa3
💜Thank you Kerry Savage @pammckay123@sabobillo & @Dr_KatLewis - very engaging discussion & opportunity to discuss data, caveats, practice/doubts & plans for research/future.
Watch/re-watch👇here https://t.co/vw6YQlUf8A
A real pleasure to be involved in this with an amazing group of international experts! Thank you @tobyeyre82 for leading and coordinating this comprehensive review
⏩⏩Just out in @TheLancetOncol
Pleased to shared a comprehensive overview of what we know (& don't know!) about CNS prophylaxis in #DLBCL. Big thanks to stellar team of global co-authors 🔥 #lymsm
CNS prophylaxis for diffuse large B-cell lymphoma https://t.co/1Wx7wl3X9H
Comparative effectiveness of ZUMA-5 (axi-cel) vs SCHOLAR-5 external control in relapsed/refractory follicular lymphoma @ASTCT@lymphomahub@TheEBMT@EHA_Hematology https://t.co/BhL73tpiUq
10 major studies looking at CNS prophy in DLBCL. Only 1 (the smallest) positive. Who is still doing CNS prophy?
I still do IT MTX x4 if double hit based on Petrich (Blood 2014) showing OS benefit and for testicular (based on IELSG phase 2). Not for all CNS-IPI 4-6 though