Sahar Nissim, MD, PhD

Physician-Scientist
#PancreaticCancer Researcher
Assistant Professor, Harvard Medical School
@DanaFarber, @DanaFarber_Hale, @BrighamWomens, @HarvardMed

[Sahar Nissim, MD, PhD @SaharNissim]

https://t.co/fcrwMQf3tl seeks a postdoc for studies on #epigenetics, #PancreaticCancer. Transcription factor networks + epigenetic barriers maintain cell identity. How are these disrupted to promote cancer? Can we target these for interception? DM with interest! @DanaFarber_Hale

[Sahar Nissim, MD, PhD @SaharNissim]

Can we restrain, reverse, or eliminate pancreatic precancers before they become invasive? Following #AACRpan26, @Aiims1742 @BenStanger01 @MadameSurgeon and I discuss hopes for #PancreaticCancer interception in @Nature.

https://t.co/HxpnocaoLI

[Sahar Nissim, MD, PhD @SaharNissim]

Fantastic science at #AACRpan26! Grateful for the enthusiasm and feedback on our work developing a PDAC interception strategy by targeting NR5A2. Thanks to our team as we work toward new options for high-risk individuals! @DanaFarber_Hale @AACR #PancreaticCancer

[AACR @AACR]

From Detection to Interception: Redefining the Earliest Stages of Pancreatic Cancer—#AACRpan26 cochair Diane M. Simeone, Ben Z. Stanger, Nuria Mallats, Raymond Wadlow, and @SaharNissim addressed this topic in a plenary at the AACR Conference on Pancreatic Cancer.
@MadameSurgeon

[Sahar Nissim, MD, PhD @SaharNissim]

@AneyKatie @jonathan_nowak @DanaFarber_Hale @BWHGenetics @BrighamGI @TheVFoundation (14/14) Interested in acinar metaplasia or pancreas precancer biology?

Give FixNCut a try—and please reach out with questions or ideas. We're excited to keep pushing this field forward and ultimately inform new early detection and interception strategies for #PancreaticCancer !

[Sahar Nissim, MD, PhD @SaharNissim]

TY @Aiims1742!
Thrilled to share our new @AGA_CMGH paper!
Using FixNCut scRNA-seq, we uncover novel acinar metaplastic cell states and precancer programs in pancreas disease.
https://t.co/BottGlQ2Fj
Led by the amazing @Aney_Katie and Woo-Jeong 👏🧵👇

[Anirban Maitra @Aiims1742]

New paper in @AGA_CMGH from @SaharNissim
Novel Acinar Metaplastic States Uncovered in Exocrine Pancreas Disease
https://t.co/GMztVdoYl3
Using FixNCut (which preserves RNA integrity in the pancreas), this study explores acinar plasticity & lineage state heterogeneity in PanINs.

[Sahar Nissim, MD, PhD @SaharNissim]

@AneyKatie @jonathan_nowak (13/14) Many thanks to the support of @DanaFarber_Hale, @BWHGenetics, @BrighamGI, @TheVFoundation, and our generous and visionary philanthropic donors. 🙏

[Sahar Nissim, MD, PhD @SaharNissim]

To all the hard-working trainees out there...

The 4 stages of conference attendance:
1. Nobody knows me, I know nobody
2. Nobody knows me, I know everybody
3. Everybody knows me, I know everybody
4. Everybody knows me, I know nobody

Have fun & keep striving in the progression!

[Sahar Nissim, MD, PhD @SaharNissim]

So proud of @AneyKatie drawing a crowd at @AACR PDAC! Beautiful story in the works to understand how acinar identity unravels on the way to cancer.

[Sahar Nissim, MD, PhD @SaharNissim]

https://t.co/9QLIr5FAJC

[Sahar Nissim, MD, PhD @SaharNissim]

1/17
Thrilled to announce our @AGA_Gastro paper, where we tackle the challenging exocrine #pancreas context to achieve unprecedented scRNA-seq definition of cell landscapes in homeostasis, #AcutePancreatitis, and recovery. Led by NissimLab @aneykatie + Woo-Jeong Jeong. 🧵👇

[Sahar Nissim, MD, PhD @SaharNissim]

17/17
Give FixNCut a try and please reach out with any comments or questions… we’re excited to compare data and illuminate the field together!