Polaryx Therapeutics (Nasdaq: PLYX) is developing a multi-modal pipeline of patient-friendly small molecule and gene therapy treatments to treat lysosomal storage disorders. Polaryx is advancing SOTERIA, a Phase 2 basket trial evaluating multiple LSDs at once.
🚨 OFFICIAL: Kylian Mbappe’s camp reacts with a statement to AFP on recent criticism.
“Part of the criticisms are based on an overinterpretation of elements related to a recovery period strictly supervised by the club”.
“This is NOT corresponding to the reality of the commitment and the work that Kylian does daily for the good of the team”.
Beef and Noodles
Ingredients
2 teaspoons kosher salt
2 teaspoons ground black pepper
3 pounds brisket or tri-tip (optional upgrade)
2 tablespoons olive oil
1/2 cup red wine (optional)
2 cups diced carrots
1 cup diced onion
3 cloves garlic, minced
2 tablespoons tomato paste
4 cups beef stock
2 cups water
2 tablespoons fresh thyme
2 bay leaves
12 ounces egg noodles or pappardelle
1/2 cup frozen peas or mixed vegetables
Instructions
Preheat oven to 325°F.
Season your beef with salt and pepper; set aside.
Heat oil in a Dutch oven and sear beef on all sides. Remove and set aside.
Sauté carrots and onion until fragrant, then add garlic. Deglaze with red wine (if using).
Stir in tomato paste, then pour in beef stock, water, thyme, and bay leaves. Simmer and return beef to the pot.
Cover and bake for 2.5–3 hours until beef is tender.
Shred beef in the pot. Bring the liquid to a boil, adding noodles and peas. Cook until noodles are tender (10–12 minutes).
Serve with crusty bread or a light green salad for a balanced meal.
PISTONS or CAVS... Who do you have advancing?
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Chicken Caesar Salad Pizza 🍕😁
Ingredients (Serves 2–3)
Pizza base:
1 pizza dough (store-bought or homemade)
1–2 tablespoons olive oil
1 cup shredded mozzarella cheese
1/4 cup grated Parmesan cheese
Chicken:
1 chicken breast, diced
1 tablespoon olive oil
1/2 teaspoon garlic powder
Salt and black pepper to taste
Caesar salad topping:
2 cups romaine lettuce, chopped
1/3 cup Caesar dressing
2 tablespoons grated Parmesan
Fresh black pepper
Optional:
Caesar dressing for drizzle
Extra Parmesan for topping
Instructions
1. Cook the chicken
Heat olive oil in a pan over medium heat.
Add diced chicken, season with garlic powder, salt, and pepper.
Cook until golden and fully cooked (about 6–8 minutes). Set aside.
2. Preheat oven
Preheat oven to 475°F (245°C) or as hot as your oven allows.
3. Prepare the dough
Roll out pizza dough on a floured surface to desired thickness.
Transfer to a baking tray or pizza stone.
Brush lightly with olive oil.
4. Build the base pizza
Sprinkle mozzarella evenly over the dough.
Add cooked chicken pieces.
Top with a light layer of Parmesan.
5. Bake
Bake for 10–12 minutes until:
Crust is golden and crisp
Cheese is melted and bubbling
6. Prepare Caesar topping
In a bowl, toss romaine lettuce with:
Caesar dressing
Parmesan
Black pepper
7. Assemble (key step for the look)
Remove pizza from oven.
Top generously with the dressed romaine salad.
Drizzle a little extra Caesar dressing and sprinkle more Parmesan on top.
Tips for the same result as the picture
Add lettuce after baking to keep it fresh and crisp
Use high heat for a blistered, golden crust
Don’t overdress the salad—keep it light and glossy
Use freshly grated Parmesan for best flavor
Serving
Slice and serve immediately while the crust is hot and the salad is fresh.
The SEC has settled its lawsuit against Elon Musk over delayed disclosure of his 2022 Twitter stake. Elon will pay $1.5M without admitting wrongdoing.
Elon's lawyer Alex Spiro: “Mr. Musk has now been cleared of all issues related to the late filing of forms in the Twitter acquisition, as we said from the outset he would be. A trust vehicle has agreed to a small fine for being late on one filing.”
The SEC had originally sought $200 million.