Mitchell Sammut

PhD(c) @WesternU 🇨🇦 | Endlessly fascinated by metabolic physiology, cardiometabolic disease, exercise & pharmacology🏋️‍♂️🔬

[Mitchell Sammut @SammutMitchell]

Think resistance training only drives skeletal muscle adaptations? Think again.

Our new paper in MSSE shows RET also enhances lipolytic signalling in visceral adipose tissue in female rats.

↓ visceral fat mass
↓ fasting glucose
↔ body weight
DOI: 10.1249/MSS.0000000000004014

[Nature Reviews Cardiology @NatRevCardiol]

New online! Dyslipidaemia and hepatic steatosis: mechanisms and implications for lipid-lowering therapy https://t.co/EfWTUpOjPs

[Michalis Nikolaidis @mg_nikolaidis]

1/13 How many calories does it take to build 1 kg of muscle?

The question is straightforward but, as far as we can tell, it has not yet been answered quantitatively.

https://t.co/4NUq9Moiyk

[Nature Metabolism @NatMetabolism]

Multi-organ proteomic atlas of obesity regression in male mice https://t.co/5GzLt7kN8Q

[Anna Vainshtein, PhD @VainshteinAnna]

A century ago, skeletal muscle was understood largely as the body’s engine. We now know that is much more vital

Our new framework in @NatMetabolism: The Hallmarks of Skeletal Muscle Health. 🧵

🔗 https://t.co/t9S3BdK3IH

#myotwitter

[Gilles Gouspillou @GGouspillou]

Exercise intensity modulates interorgan communication and is associated with cardiometabolic health outcomes in humans: Cell Reports Medicine https://t.co/Jc8j82ElCn

[Cell Metabolism @Cell_Metabolism]

New! Online now: Beta2-adrenergic stimulation by fenoterol increases energy expenditure without activating human brown adipose tissue https://t.co/Jf3EY48cDS

[Bruno Ramos-Molina, PhD @Brunorm84]

GDF15 suppresses liver inflammation independently of weight loss through neuroendocrine glucocorticoid signaling #MASH @Cell_Metabolism https://t.co/EipmkPcngF

[Daniel J Drucker @DanielJDrucker]

A framework identifying ten priorities in #T2D prevention, toward context-specific, actionable interventions capable of altering the natural history of disease early in the life course and restoring metabolic health. https://t.co/P6fkgvy8T8

[Daniel Berglind, PhD @DanielBerglind]

Resistance training benefits more than muscle after menopause.
A meta-analysis of 60 studies found significant improvements in resting heart rate and blood pressure, with the largest effects for systolic and mean BP.

https://t.co/GI8lKkcde4

[Cell Metabolism @Cell_Metabolism]

Insulin resistance and type 2 diabetes as allostatic responses to chronic nutrient excess https://t.co/8MEaAK6Mho

[nature @Nature]

A massive genomic study has linked mutations in a specific gene to an increased proportion of muscle, decreased levels of belly fat and blood sugar and a reduced risk of conditions including heart disease

https://t.co/r4UEYawS2M

[Trends in Endocrinology & Metabolism @Trends_Endo_Met]

Online Now: Broadcasting live: a genetic proximity labelling mouse model to map cell-specific secretomes https://t.co/tMbQ6iZmmV #trends #endocrinology #metabolism

[Cell Metabolism @Cell_Metabolism]

New! Online now: Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity https://t.co/qMxvzKWzBi

[University Health Network @UHN]

UHN’s president and CEO is challenging government, industry and academia to think bigger and act faster. Dr. @KevinSmithUHN has a bold proposal to accelerate health innovation for Canadian patients, communities and the economy here at home.

Learn more: https://t.co/1DdPgrS5C2

[Cell Metabolism @Cell_Metabolism]

New! Online now: Brown fat protects against hepatic oxidative stress by remodeling the circulating metabolome https://t.co/fNzDMHphvy

[Leigh Goedeke, PhD @GoedekeLeigh]

Thrilled to share our latest work, now published in @ScienceTM! We show that targeting mitochondrial energetics can simultaneously improve metabolic and vascular health.

Learn more: https://t.co/4XuG2fFxst

@SinaiHeartBlood @IcahnMountSinai

[Crémieux @cremieuxrecueil]

We now have meta-analytic confirmation:

Adding exercise on top of caloric restriction leads to more weight loss.

It also leads to better weight loss, with less of the weight lost as lean mass, and more of it lost as fat mass.

[Henning Wackerhage @HeWaHippo]

Skeletal muscle biomass as an underappreciated fate of glucose | American Journal of Physiology-Cell Physiology | American Physiological Society https://t.co/B7nRdC20Vk

[Nature Reviews Endocrinology @NatureRevEndo]

New content online: Strengthening the metabolic alliance: exercise as an essential partner of obesity pharmacotherapy https://t.co/Rm2pPgJz3y

[Simon Hill MSc, BSc @theproof]

We have spent decades treating the number on the scale as the goal. What if it was never the right target?

Dr Mauricio Gonzalez, a triple board-certified physician and endocrinology fellow, joins me to explain why liver fat, not body weight, is becoming the real measure of metabolic health, and what that means for how we think about GLP-1 medications, cholesterol, and longevity.

For the full show notes head to: https://t.co/f2sGSaQ4lB