Samuel Widodo

PhD @unimelb | Brain tumour microenvironment research; macrophage enthusiast | 🇮🇩🇦🇺

[Theo Mantamadiotis @BrainCancerLab @Theo_BrainC_lab]

Carcinogenesis: https://t.co/YPeAN5Ga8V Mice with targeted Pi3k-Pten mutations develop tumors resembling an aggressive form of sex cord stromal tumors. We describe the cell-of-origin, complex histopathology & using #spatialbiology, map immune cell infiltration of this rare cancer

[Samuel Widodo @samuelsw]

@Theo_BrainC_lab @aruthak to those asking & to be clear the images in the original post used images from the published article focussing on brain tumour analysis - these images are not lung cancer

[Samuel Widodo @samuelsw]

@dinevska_marija & @Theo_BrainC_lab This review is special bcs we love spatial biology & want to contribute to expanding the treatment choices for patients & their families. Special thanks to @marianna_raps and @martinelliadr for the collaboration and insights.

[Samuel Widodo @samuelsw]

We share our review discussing several key studies investigating the immunosuppressive tumour microenvironment, with a focus on brain cancer​
https://t.co/0GMd9x5dPT

@dinevska_marija @Theo_BrainC_lab

[Samuel Widodo @samuelsw]

We have used some of these technologies to demonstrate preferential distribution of T-cells in ECM-rich regions in both primary & metastatic brain tumours

https://t.co/CvINxo2PbW
https://t.co/tJyNhT9Wpi

[Samuel Widodo @samuelsw]

Thanks Theo, I’m looking forward to seeing this research in press too!

[Theo Mantamadiotis @BrainCancerLab @Theo_BrainC_lab]

Very proud to witness the excellent PhD oration seminar by Samuel @samuelsw about a mechanism in #GBM TAMs which can be targeted, to reverse tumor immunosuppression. Looking forward to seeing this research in press, in the near future!

[Samuel Widodo @samuelsw]

Thanks Marija, I wouldn’t have made it this far without your support!

[Marija Dinevska @dinevska_marija]

Congratulations on your completion seminar @samuelsw! So exciting to see all your hard work come together 🎉🎉👏👏

[Theo Mantamadiotis @BrainCancerLab @Theo_BrainC_lab]

Back at #lornecancer! Highlight was @michelle_monje 's neuro-glioma talk! photo with fabulous researchers @samuelsw @dinevska_marija @BerrocalRubio checkout SW's poster #215 'Transcriptional reprogramming of tumour associated macrophages in glioblastoma'

[Theo Mantamadiotis @BrainCancerLab @Theo_BrainC_lab]

Our review on how a master transcriptional regulator of brain function & immunity, CREB, is co-opted to support brain tumour development @UniMelbMDHS @TheDohertyInst @drlaura_cook @dinevska_marija @samuelsw #glioblastoma #brain #TME #immunosuppression
https://t.co/2RXXtC6zXT

[Marija Dinevska @dinevska_marija]

If you're interested in the spatial analysis of spheroids/organoids/tumorspheres,
check out our new published protocol chapter in Neurobiology Methods & Protocols. https://t.co/PYKvjqAikd @Theo_BrainC_lab @samuelsw We thank editor @DworkinSeb

[Theo Mantamadiotis @BrainCancerLab @Theo_BrainC_lab]

#Glioblastoma initiation visualized using @AkoyaBio Phenocycler 2.0 showing transition of neural #stemcells into #GBM cells. H&E image published in doi: 10.1093/neuonc/noy068. Using multiplex-IHC we can now see cell-molecular changes occurring during GBM development @UniMelbMDHS

[Theo Mantamadiotis @BrainCancerLab @Theo_BrainC_lab]

Incredible depth & clarity of mouse brain & mouse brain tumor tissue using @AkoyaBio Phenocycler-Fusion 2.0 combining barcoded antibody labeling & AI-assisted cell-immune-tissue phenotyping. CHECK POSTER @ #sfn2023 #research @UniMelbMDHS #GBM #glioblastoma #neuroscience #cancer

[Miguel A. Berrocal Rubio @BerrocalRubio]

Today at the Melbourne Brain Symposium, presenting our multi-omics approach to characterize the molecular diversity of the myeloid lineage.

@mincle & the Well's lab are working towards identifying novel myeloid transcripts and proteins that explain macrophage diversity (1/2).

[Samuel Widodo @samuelsw]

A great conference with a diverse range of speakers with the same focus of tackling cancer. I felt honoured to be given the opportunity to share my PhD work, thanks to the organisers @VCCCAlliance #VCCCA23

[Theo Mantamadiotis @BrainCancerLab @Theo_BrainC_lab]

Great rapidfire presentation from @samuelsw @ #VCCCA23 about targeting macrophage-driven, CREB-dependent immunosuppression in brain cancer @UniMelbMDHS @TheDohertyInst #GBM #BrainCancer #glioblastoma

[Samuel Widodo @samuelsw]

@jack_chan15 @EACRnews Thanks Jack! It is indeed.

[Samuel Widodo @samuelsw]

I am grateful to the @EACRnews for the travel award, which enabled me to present my research at #EACR2023 Congress in Torino, Italy.

[EACR @EACRnews]

We’re delighted to have awarded 71 Travel Grants to help researchers from 24 countries to attend #EACR2023 – congratulations to all of you!

[Theo Mantamadiotis @BrainCancerLab @Theo_BrainC_lab]

@UniMelbMDHS PhD graduate researchers @samuelsw & @dinevska_marija @ #EACR2023 Torino, presenting their fabulous discovery research: mapping cancer cell & immune cell activity, & ECM, in #glioblastoma #GBM & #brainmet #TME using @AkoyaBio #spatialbiology #pathology 4 #BrainCancer

[Samuel Widodo @samuelsw]

@dinevska_marija and I will be presenting our posters on investigating the cellular and transcriptional mechanisms regulating tumor immunosuppression in glioblastoma & metastatic brain cancer. Find us at P-0515 and P-0533. #EACR2023 @Theo_BrainC_lab