Sara Hakim

Interested in neuroimmune interactions, pain, and diabetic neuropathy | @Harvard Ph.D. @UCSanDiego B.S. | 🇪🇬🇺🇸🌍

[Sara Hakim @sarainthelab]

My PhD work is finally out in @Nature this week! Again, really grateful for all the support I received from mentors and labmates to get this over the finish line. The revision process has uncovered a few more insights that I think are worth pointing out.
https://t.co/L4umgo4WC6

[Sara Hakim @sarainthelab]

Excited to share this pre-print from my thesis work. I spent the past few years developing a model of diabetic neuropathy and unexpectedly found that macrophages infiltrate the nerves of diabetic mice and their recruitment is neuroprotective!! https://t.co/yisVM6XBMc

[IASP @IASPpain]

Read this #EditorsPick from #PapersoftheWeek from @sarainthelab et al. and @Nature showing evidence that recruitment of macrophages into peripheral nerves delayed terminal sensory axon degeneration in a mouse model of diabetic peripheral neuropathy https://t.co/5iMcFywZSn #PRF

[Sara Hakim @sarainthelab]

@AdrianoAguzzi @Nature Thanks!! And thanks for sharing! I agree, i think it’s important as a field to be specific about the subpopulations of macs/microglia we are studying because in reality there’s probably both “good” and “bad” ones at play at different disease stages that need to be understood.

[Sara Hakim @sarainthelab]

My PhD work is finally out in @Nature this week! Again, really grateful for all the support I received from mentors and labmates to get this over the finish line. The revision process has uncovered a few more insights that I think are worth pointing out.
https://t.co/L4umgo4WC6

[Sara Hakim @sarainthelab]

Excited to share this pre-print from my thesis work. I spent the past few years developing a model of diabetic neuropathy and unexpectedly found that macrophages infiltrate the nerves of diabetic mice and their recruitment is neuroprotective!! https://t.co/yisVM6XBMc

[Sara Hakim @sarainthelab]

@EidSteph @Nature Thank you!! 😊

[Sara Hakim @sarainthelab]

@FaltasLab @Nature Thank you!

[Sara Hakim @sarainthelab]

@olgachaim @Nature Thank you for always cheering for me🤍

[Waggoner Lab @LabWaggoner]

Macrophages protect against sensory axon loss in peripheral neuropathy @Nature @sarainthelab
https://t.co/HSOMdgBaDx

[Sara Hakim @sarainthelab]

@TheIbrahimLab Thank you!! 😊

[Veselina Petrova @ves_petrova]

So very proud of my ex-lab mate and forever friend, @sarainthelab! Her PhD paper is an extraordinary body of rigorous research which I believe will shape the field of peripheral neuropathy for years to come!

https://t.co/MxC01u7e8R

[nature @Nature]

Nature research paper: Macrophages protect against sensory axon loss in peripheral neuropathy

https://t.co/Qj4Dh6cDQO

[Sara Hakim @sarainthelab]

Finally, we looked at both skin and DRGs of mice fed HFHFD and found no overt recruitment of macrophages suggesting this is likely a response to something happening in the peripheral nerves (again, potentially accumulation of AGEs or SFAs)

[Sara Hakim @sarainthelab]

We find that mice lacking Galectin-3 have a similar phenotype to mice lacking macrophage recruitment and think that Galectin-3 could be contributing to the neuroprotective effect exerted by CCR2+macs.. potentially helping clear AGEs or excess Fatty Acids? TBD

[Sara Hakim @sarainthelab]

@ves_petrova 🥹 Thank you for your constant support and all your help with this project!! 🤍

[IASP @IASPpain]

Featured as an #EditorsPick, at a look at this #PapersoftheWeek find from @sarainthelab and @NatImmunol reviewing the various immune drivers, like cytokines and endogenous opioids, impacting pain resolution and protection https://t.co/eF9xxaTKpq

[Pain Research Forum @PainResForum]

Featured as an #EditorsPick, at a look at this #PapersoftheWeek find from @sarainthelab and @NatImmunol reviewing the various immune drivers, like cytokines and endogenous opioids, impacting pain resolution and protection https://t.co/hqRfspthE1

[Carlos Gevers @carlosgeversdc]

Beautiful paper by @sarainthelab @Aakanksha__Jain & Clifford J Woolf @BostonChildrens: Immune drivers of pain resolution and protection
https://t.co/ayBTl3JynR

[Sara Hakim @sarainthelab]

@carlosgeversdc @Aakanksha__Jain @BostonChildrens Thank you!!

[Veselina Petrova @ves_petrova]

Our latest paper details part of our unbiased, high-throughput screening efforts to uncover neuroprotective compounds against chemotherapy-induced degeneration on motor and sensory neurons. 4/1902 compounds worked across both neuronal subtypes. @PhRMA

https://t.co/sPFyi47J81

[Sara Hakim @sarainthelab]

Guess who made it to the cover of @NatImmunol 🙋🏽‍♀️✨🥺

[Aakanksha Jain @Aakanksha__Jain]

Check out our recent work @NatImmunol highlighting how every pain condition is different, and immune cells might hold the key to these differences. As a cherry on top, our DRG image was chosen as the cover art 😃
P.C. @sarainthelab
https://t.co/Vx2YsbsvjX