Sarah Brüningk

Postdoctoral Researcher at the Machine Learning & Computational Biology Lab
@AGKBorgwardt
at @ETH
Zürich

[Paulina Scheuren @ScheurenPaulina]

Interested in ongoing clinical trials in #SpinalCordInjury❓

Check out our @SCITrialsFinder website🖥️:
✅ Trials carefully curated by experienced investigators
✅ Easy to understand trial summaries
✅ Instant notifications about new trials
✅ Seamless contact to trial locations

[Carlo Cervia-Hasler @carlo_cervia]

Our work on #LongCovid 🩸 is now out in @ScienceMagazine!

We found increased complement activation and markers of thromboinflammation in patients with active Long Covid.
1/

https://t.co/mjD8Vsd4SG

[Carlo Cervia-Hasler @carlo_cervia]

Altogether, an overly activated complement system may connect different hypotheses on Long Covid pathomechanisms.

While the results require further validation in larger patient cohorts, they provide a basis for new diagnostic solutions and possibly targeted treatments.
9/

[Carlo Cervia-Hasler @carlo_cervia]

By measuring antibodies against >80’000 viral epitopes we found increased IgG against #herpesviruses in Long Covid patients, particularly against CMV and EBV.

Anti-CMV was associated with markers of antibody-mediated complement activation.
8/

[Carlo Cervia-Hasler @carlo_cervia]

But why is complement activated in the first place?
1) Tissue injury can be caused by, and activate, complement 🔄
2) Cross-talk with a dysregulated coagulation system ↔️
3) Classical activation mediated by antibodies ⬇️
7/

[Carlo Cervia-Hasler @carlo_cervia]

Using #MassSpec, we found increased markers of tissue injury, including red blood cells, platelets, and endothelial cells.

#FlowCytometry paired with #scRNAseq showed increased monocyte-platelet aggregates in Long Covid patients.
6/

[Carlo Cervia-Hasler @carlo_cervia]

Functional assays revealed increased complement activation. Increased C5bC6 serum levels contrasted with the decrease of C7 complexes.

This pattern suggested increased incorporation of terminal complement complexes in cell membranes.
5/

[Carlo Cervia-Hasler @carlo_cervia]

Experimental validation revealed that C7 complexes were decreased in the blood of Long Covid patients. Long Covid patients that had recovered before 6-month follow-up, showed normal levels.
4/

[Carlo Cervia-Hasler @carlo_cervia]

We measured >6’500 proteins in the blood of COVID-19 patients during initial infection and 6 months later, compared to healthy controls.

6 months after infection, one protein stood out: complement C7.
3/

[Carlo Cervia-Hasler @carlo_cervia]

The complement system is part of the innate immune response and is unfortunately often forgotten right after the immunology exam.

Here’s a recap by @Kurz_Gesagt:
2/

https://t.co/PSAXxHToP5

[Carlo Cervia-Hasler @carlo_cervia]

We are very grateful to all the patients donating blood! Also huge thanks to everybody involved in generating and analyzing all data, including @SBruningk @tebiwankenebi @BrodinPetter @AdrianoAguzzi @chr_messner @noambeckmann1 @kmborgwardt and all members of the Boyman lab.
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[Alvaro Köhn-Luque @AlvaroKohn]

We review in a new preprint the synergistic combination of knowledge-driven and data-driven modeling in #mathonco with @jmetzcar @MathCancer @Jutzeler_Cathy @SBruningk and thanks also to @HauptSaskia @_Alex_Zeilmann_

https://t.co/l9JpNR8cEa

[Mariam Aboian @MariamAboian]

Towards personalized therapy in DMG with #ML by ⁦@SBruningk⁩ Treatment response curves, combining classical mathematical modeling with ML, and interpretability aware model training! ⁦@PNOC_kids⁩ ⁦@act_dmg⁩ ⁦@PNOCFoundation⁩

[Javier Santoyo @jsantoyo]

reComBat: batch-effect removal in large-scale multi-source gene-expression data integration. #BatchEffectRemoval #GeneExpression https://t.co/XtOktTYPVA @biorxiv_bioinfo

[WeComSci @WeComSci]

Excited to share an impression from our first workshop on social media communication held by @scimadesimple and Julia Ecker from @ETHCHAB!

[Sarah Brüningk @SBruningk]

It was a great experience talking to the students at St.Joseph's Academy! Thanks a lot to @SkypeScientist for this opportunity!
Engineering Students Enjoy Skype with Scientist https://t.co/WdL9raIoUU

[Basel Research Centre for Child Health @BRC_CH]

#BRCCH warmly welcomes 5 new research projects! Postdocs, together with established Investigators, will conduct translational and ambitious research in #childhealth. Read about the projects👉https://t.co/MalJzoP8GT

@UniBasel_en @ETH_en @SwissTPH
📷J.Pelikan/SwissTPH

[Karsten Borgwardt @kmborgwardt]

Our most important #COVID19 work so far: @SBruningk @JulianeKlatt & @MadStange examined determinants of SARS-CoV-2 transmission in a city, which could guide vaccination strategies. Spearheaded by @AppliedMicrobi2, w/ H. Hirsch & @UniSpitalBasel @ETH_BSSE https://t.co/Qht1SNAyr2

[AppliedMicrobiologyResearch @AppliedMicrobi2]

What impacts transmission within cities? Knowledge can guide vaccine strategies -> high populated and mobile areas, but also people with more severity. Read more here: https://t.co/vMyxUesfmD
@MadStange @SBruningk @JulianeKlatt @kmborgwardt @UniBasel_en @UniSpitalBasel @ETH_BSSE