Our research was just published in Nature Cancer (Nature Portfolio) on HIF prolyl hydroxlyases as potent therapeutic targets for AML. (1/5) https://t.co/TceR7sRHaF
IOX5 ablates AML in vitro and in vivo. Moreover, we discovered that inhibition of BCL-2 by Venetoclax synergises with PHD inhibition, revealing a promising non-toxic therapeutic strategy in AML. Great job everyone! (5/5) @OxfordChemistry@UniofOxford
Delighted to share our new work in @NatureCancer in collaboration with @SchofieldOxford led by @hannahjlawson & James Holt-Martyn. We found that HIF hydroxylases are potent therapeutic targets in AML. @ICR_London. https://t.co/cb3K90Wlot. 1/4
In @JACS_Au today! We show how D-NEMD simulations can be used to identify functionally relevant allosteric sites and communication networks in SARS-CoV-2 #Mpro, including those relevant to drug resistance
https://t.co/p6NaDhJze3 #compchem. Congrats, Henry and everyone involved!
After a long wait, extremely happy to see this work out https://t.co/VxyxvM4lVm WHATACOMPLEX! great collaboration with amazing group of people in Hiro Suga's lab Tokyo @Chem_Todai Chris S lab @SchofieldOxford and Akane Kawamura @UniofNewcastle link here: https://t.co/yx8qyJfQX0
🩻🔬🦠🧫A case study: UK and Slovene researchers are together finding new ways to tackle the growing problem of antimicrobial resistance - and keep your antibiotics working. (Bicyclic boronate inhibitors! No 🚲 involved though…) #AMR
At today’s launch for @ARRS_rfo’s UK-Slovenia Researcher Mobility Scheme, researchers working in 🇬🇧 and 🇸🇮 gathered to explore new projects and partnerships.
‘Bicyclic boronate inhibitors’ is not a phrase you hear often... But they’re crucial in fighting antimicrobial resistance. And they’re a field where 🇬🇧 - 🇸🇮 researchers are collaborating, to great effect. Thank you @ARRS_rfo for an excellent day aimed at building more such links
Your Excellency @TiffanySadlerUK, was such a great day, glad you like BCBs now 😉! With kudos to my great. former PhD advisor @SchofieldOxford + all amazing collaborators/collegues (incl. @Spencer_D60). We will continue working together 🇸🇮-🇬🇧 to combat #AMR@UL_FFA
In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating #DrugDiscovery (Zhang) @SchofieldOxford#openaccess https://t.co/zd6AgkFqTM
Day two of #DDC2022 has started with excellent scientific lectures by Prof. Dr. Christopher Schofield @SchofieldOxford and Prof. Dr. Rolf Müller @Helmholtz_HIPS! Thank You! 😊 🤩
Researchers at @OxfordChemistry, @RaphaelRe1 and @SchofieldOxford, report studies on resistance to the pioneer drug ivosidenib leading to identification of inhibitors retaining activity.
https://t.co/AgOsr1509x