Schofield Group

News from Prof Christopher J. Schofield's Group. CJS is a Fellow of the Royal Society & Professor @OxfordChemistry

[Schofield Group @SchofieldOxford]

@OxfordChemistry @UniofOxford Thanks to our funders @CRUKOxford, @theMRC

[Schofield Group @SchofieldOxford]

Our research was just published in Nature Cancer (Nature Portfolio) on HIF prolyl hydroxlyases as potent therapeutic targets for AML. (1/5) https://t.co/TceR7sRHaF

[Schofield Group @SchofieldOxford]

IOX5 ablates AML in vitro and in vivo. Moreover, we discovered that inhibition of BCL-2 by Venetoclax synergises with PHD inhibition, revealing a promising non-toxic therapeutic strategy in AML. Great job everyone! (5/5) @OxfordChemistry @UniofOxford

[Kamil R Kranc @kamilkranc]

Delighted to share our new work in @NatureCancer in collaboration with @SchofieldOxford led by @hannahjlawson & James Holt-Martyn. We found that HIF hydroxylases are potent therapeutic targets in AML. @ICR_London. https://t.co/cb3K90Wlot. 1/4

[Duarte Group @duarte_group]

In @JACS_Au today! We show how D-NEMD simulations can be used to identify functionally relevant allosteric sites and communication networks in SARS-CoV-2 #Mpro, including those relevant to drug resistance
https://t.co/p6NaDhJze3 #compchem. Congrats, Henry and everyone involved!

[Oxford Chemistry Outreach @ChemOutreachOxf]

Answering questions about research & career journeys as part of our ⁦@IneosOxford⁩ ⁦@OxfordChemistry⁩ ⁦@SchofieldOxford⁩ Bug Fight! Workshop⁩. Thank you ⁦@CartertonCC⁩ for trialling this with us today. ⁦@mplsoxford⁩ ⁦⁦@OxOutreach⁩

[Martin Walsh OBE @MartinWalshDLS]

After a long wait, extremely happy to see this work out https://t.co/VxyxvM4lVm WHATACOMPLEX! great collaboration with amazing group of people in Hiro Suga's lab Tokyo @Chem_Todai Chris S lab @SchofieldOxford and Akane Kawamura @UniofNewcastle link here: https://t.co/yx8qyJfQX0

[Schofield Group @SchofieldOxford]

Congratulations @GiorgiaFiorini6!

[Trends in Microbiology @TrendsMicrobiol]

Metallo-β-lactamase-mediated antimicrobial resistance and progress in inhibitor discovery

@alanmcn1 @IMIBirmingham @SchofieldOxford https://t.co/217I7IGNI3

[British Embassy Ljubljana 🇬🇧🇸🇮 @UKinSlovenia]

🩻🔬🦠🧫A case study: UK and Slovene researchers are together finding new ways to tackle the growing problem of antimicrobial resistance - and keep your antibiotics working. (Bicyclic boronate inhibitors! No 🚲 involved though…) #AMR

[British Embassy Ljubljana 🇬🇧🇸🇮 @UKinSlovenia]

At today’s launch for @ARRS_rfo’s UK-Slovenia Researcher Mobility Scheme, researchers working in 🇬🇧 and 🇸🇮 gathered to explore new projects and partnerships.

[Tiffany Sadler @TiffanySadlerUK]

‘Bicyclic boronate inhibitors’ is not a phrase you hear often... But they’re crucial in fighting antimicrobial resistance. And they’re a field where 🇬🇧 - 🇸🇮 researchers are collaborating, to great effect. Thank you @ARRS_rfo for an excellent day aimed at building more such links

[Alen Krajnc @krajnc_alen]

Your Excellency @TiffanySadlerUK, was such a great day, glad you like BCBs now 😉! With kudos to my great. former PhD advisor @SchofieldOxford + all amazing collaborators/collegues (incl. @Spencer_D60). We will continue working together 🇸🇮-🇬🇧 to combat #AMR @UL_FFA

[Angewandte Chemie @angew_chem]

In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating #DrugDiscovery (Zhang) @SchofieldOxford #openaccess https://t.co/zd6AgkFqTM

[National Research and Innovation Institute (NIRI) @niri_lv]

Day two of #DDC2022 has started with excellent scientific lectures by Prof. Dr. Christopher Schofield @SchofieldOxford and Prof. Dr. Rolf Müller @Helmholtz_HIPS! Thank You! 😊 🤩

[Nature Communications @NatureComms]

Researchers at @OxfordChemistry, @RaphaelRe1 and @SchofieldOxford, report studies on resistance to the pioneer drug ivosidenib leading to identification of inhibitors retaining activity.

https://t.co/AgOsr1509x

[Nils Frank @1999Nils]

I am delighted to see that our work on using [3.1.1]propellane to derive meta-arene bioisosteres is accepted in @Nature https://t.co/CR9fpK99Lk

@EdAndersonGroup @duarte_group @GroupBrennan @SchofieldOxford @abbvie @Jeremy__Nugent @BethanyShire @helenapickford @ASterlingChem