Science Immunology

Science Immunology publishes original, peer-reviewed research articles that report critical advances in all areas of immunological research.

[Science Immunology @SciImmunology]

A new Science #Immunology study in mice shows that loss of #Langerhans cells in early life reduces antigen transport to draining lymph nodes and impairs T cell responses in adults. https://t.co/tkhe61JIBa

[Science Immunology @SciImmunology]

Restoring MHC-I expression on tumor cells and harnessing antitumor CD4 T cells with CTLA-4 blockade could reduce #metastasis in #immunotherapy-resistant pancreatic cancer.

Learn more in Science #Immunology: https://t.co/CGeW2vgG1K

[Science Immunology @SciImmunology]

In mice, #Langerhans cells regulate lymphatic growth in the skin by producing VEGF-C and PIGF and shape immune responses in adulthood.

Learn more in Science #Immunology: https://t.co/tkhe61JIBa

[Science Immunology @SciImmunology]

A new Science #Immunology study shows that PD-L1 blockade can inhibit MHC-I presentation on tumor cells, enabling immune evasion and #metastasis in mouse models of #pancreatic cancer. @IngunnStromnes https://t.co/CGeW2vgG1K

[Science Immunology @SciImmunology]

Streptococcal #meningoencephalitis can deplete dural #macrophages and remodel recruited monocyte lineages, reshaping immune dynamics in the central nervous system.

Learn more in Science #Immunology: https://t.co/UPsFRp6htK

[Science Immunology @SciImmunology]

Blocking IL-17A–producing γδ T cells reduces social and anxiety-like behaviors in a mouse model of 15q11-q13 duplication syndrome, which could inform future interventions for #autism spectrum disorder.

Learn more in Science #Immunology: https://t.co/dyS6VMmPx4

[Science Immunology @SciImmunology]

A DNA-chemokine nanoparticle adjuvant can simultaneously enhance immune activation and memory T cell recruitment to the genital tract, promoting protection against genital herpes after intravaginal boosting in mice.

Learn more in Science #Immunology: https://t.co/R3ZEyjurvF

[Science Immunology @SciImmunology]

A new Science #Immunology study in mice demonstrates how group B #streptococcus infections in the meninges can trigger dural #macrophage depletion and trigger emergency monocyte production in the skull and peripheral marrow. https://t.co/UPsFRp6htK

[Science Immunology @SciImmunology]

A new Science #Immunology study shows that recruitment of #IL17A–producing γδ T cells to the brain shapes social behavior in a genetic mouse model that recapitulates features of #autism spectrum disorder. https://t.co/dyS6VMmPx4

[Science Immunology @SciImmunology]

A new Science #Immunology study in mice showcases a vaccine adjuvant that can induce protective immunity against herpes simplex virus 2 (HSV-2) infections without causing excessive local inflammation. @VirusesImmunity @sachinbhag
https://t.co/R3ZEyjurvF

[Science Immunology @SciImmunology]

A new Review examines the regulation of #IL17 signaling pathways and highlights how the cytokine can shape #immunometabolism, regulate neuroimmune interactions, and promote tumor growth.

Learn more in Science #Immunology: https://t.co/np6Rxi2DXF

[Science Immunology @SciImmunology]

A new Science #Immunology study demonstrates how RNA editing can destabilize or stabilize #dsRNA via different mechanisms, and shows that unleashing the latter can hinder #tumor growth in mice. https://t.co/bopxCSqQYp

[Science Immunology @SciImmunology]

A new Science #Immunology Review highlights the diverse tissue-specific functions of #IL17 and discusses the potential for targeted therapies to control IL-17–mediated inflammation. https://t.co/WPrwa0bLaj

[Science Immunology @SciImmunology]

The RNA helicase DDX6 promotes immunosuppression in #cancer by repressing ADAR1-mediated #dsRNA stabilization, preventing interferon activation. Learn more in Science #Immunology: https://t.co/bopxCSqQYp

[Science Immunology @SciImmunology]

A new atlas of human gut-associated lymphoid tissue demonstrates interactions between different B cell subsets, hinting at how the appendix mediates immune equilibrium while constantly sampling gut microbes.

Learn more in Science #Immunology: https://t.co/3tvaTTKB3B

[Science Immunology @SciImmunology]

A new Science #Immunology study highlights an approach called Effero-seq, which shows that #efferocytosis of tumor cells in mouse models of melanoma can induce protumoral functions in #macrophages. @meravcohen8 https://t.co/AD8rXbbvbZ

[Science Immunology @SciImmunology]

A new Science #Immunology study has identified subsets of tumor-associated #NaturalKiller cells in patients with lung #cancer, and shows that a subset of CD39+ cells can be selectively targeted to boost cytotoxicity ex vivo. https://t.co/aBLlS0r8PK

[Science Immunology @SciImmunology]

A new Science #Immunology study identified the distribution and immune interactions of immunomodulatory B cells in the human #appendix, and shows that they are disrupted during ulcerative #colitis. @JoSpencerLab https://t.co/3tvaTTKB3B

[Science Immunology @SciImmunology]

A new approach combines fluorescent labels and single-cell RNA sequencing to analyze transcriptional changes after #efferocytosis of tumor cells in #macrophages.

Learn more in Science #Immunology: https://t.co/k2vCAZFtgz

[Science Immunology @SciImmunology]

A subset of tumor-associated #NaturalKiller cells show enhanced cytotoxicity and respond to inhibitory checkpoint blockades, showcasing their potential as #immunotherapeutic targets for lung cancers. @AlfredZippelius @EricVivier1
https://t.co/s5ZfjU48JJ