Seth D. Temple

PhD, he/him, @LosAlamosNatLab @um_midas @UWStat

I am rarely on social media but will post informative threads when I publish a scientific paper.

[Seth D. Temple @sdtemple]

Presenting our new scan that uses IBD segments to detect genetic associations with cohorts stratified by a categorical variable (i.e., case-control studies).
https://t.co/NWSy0LXU69

[AJHG @AJHGNews]

🧬New from @sdtemple et al!
📄Multiple-testing corrections in case-control studies using identity-by-descent segments

https://t.co/qdGkl7QhIE

[bioRxiv Genetics @biorxiv_genetic]

FLARE2: local ancestry inference with poorly-matched reference panels https://t.co/Cb2qwvy4OJ #biorxiv_genetic

[Seth D. Temple @sdtemple]

Overall, the method is a scalable and interpretable way to look for haplotype homozygosity in biobanks. I have spent a lot of time implementing it to make it user friendly. Running this can be important to check for confounding: see our other preprint.
https://t.co/LxQm3WHQZ5

[Seth D. Temple @sdtemple]

The final thesis chapter is published OA at @AJHGNews ! In short, we determine a valid significance level for a "selection" scan and apply it to 3 ancestry groups in 2 biobanks. 🧵 for updates from the helpful peer review.
https://t.co/5FtIJtPJ8R

[Seth D. Temple @sdtemple]

While we have improved (made a more conservative threshold for the African American analysis), there are still unmodeled complexities and likely fine-scale structure that violates our assumption. Buyer beware if signal is weak (barely GW significant)!

[AJHG @AJHGNews]

📣New from @sdtemple & Browning!
📄Multiple-testing corrections in selection scans using identity-by-descent segments
https://t.co/RskSqIPhkp

[Seth D. Temple @sdtemple]

This is a new conceptual figure which explains how to make our proofs. I hope this idea is helpful to other population geneticists.

[Seth D. Temple @sdtemple]

Our paper on the limiting distribution of IBD rates (Gaussian) is now published in TPB. Really an amazing experience to work with and learn from Prof Elizabeth Thompson!
https://t.co/ed5TqyYMoS

[Seth D. Temple @sdtemple]

This project completes my development of our suite of methods called isweep, which can detect recent selection and case-control associations, can narrow in on the selection signal, and has fast local simulations to perform statistical inference.

[Seth D. Temple @sdtemple]

The test is a two-sample modification of the one-sample selection scan from my prior work (Temple and Thompson, 2025): high IBD rates differences in cases versus controls could indicate a genetic association.

[Seth D. Temple @sdtemple]

You can also run a fast scan with randomized phenotypes to double check if selection is confounding.

[Seth D. Temple @sdtemple]

Presenting our new scan that uses IBD segments to detect genetic associations with cohorts stratified by a categorical variable (i.e., case-control studies).
https://t.co/NWSy0LXU69

[Seth D. Temple @sdtemple]

The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structure https://t.co/Ow4jKodj0m