Seiichi Mori

がんゲノム研究者です。論文に対するコメントは私自身または私の所属するグループのためのメモとして書いています。つぶやきは個人の見解であり、所属機関のものではありません。論文の引用は必ずしも完全な理解や全面的な肯定を意味しません。

[Seiichi Mori @seiichi_mori]

“Applied to mouse and human brains, Spatial-ATAC-Hi-C revealed distinct chromatin architecture and gene regulatory programs in neuronal and non-neuronal populations in their native tissue context.”

[Seiichi Mori @seiichi_mori]

Spatial chromatin architecture and accessibility co-profiling of mammalian tissues
https://t.co/PTIKHCcCVS

[Seiichi Mori @seiichi_mori]

“Here we present Spatial-ATAC-Hi-C, a microfluidic‑based platform for genome-wide, spatially resolved joint-profiling of 3D genome organization and chromatin accessibility on tissue slides.”

[Seiichi Mori @seiichi_mori]

“•Mutant KRAS allelic imbalance is likely an early event and may lead to MDM2 gain
•Organ-specific metastasis risk based on prior metastases, tumor location, genomics”

[Seiichi Mori @seiichi_mori]

Integrated clinicogenomic analysis reveals the evolution and metastatic tropisms of advanced colorectal cancer
https://t.co/XFkMDw5B3b

[Seiichi Mori @seiichi_mori]

“•Prospective targeted sequencing of >7,000 colorectal cancers in the clinical setting
•Recurrent alterations in CRC are often clonal and enhanced by allelic imbalance”

[Atsushi SHIMIZU @atsushi_ngs]

今回はDNAメチル化解析の結果も大幅に追加してもらいました。生活習慣などで変化する遺伝子のスイッチに興味がある方はぜひアクセスしてください。

[Seiichi Mori @seiichi_mori]

The misunderstood sex chromosome: how X affects your health https://t.co/a3V2aWDiCj

[Seiichi Mori @seiichi_mori]

性染色体と疾患を巡る常識を見直す（後編） https://t.co/d601Y87N0y

[Seiichi Mori @seiichi_mori]

性染色体と疾患を巡る常識を見直す（前編） https://t.co/iew4eDkogs

[Seiichi Mori @seiichi_mori]

“The perireservoir region adjacent to CAR-T cell reservoirs exhibited dense CD8+ infiltration, cleaved caspase-3-mediated apoptosis, and suppressed Ki67 expression, in contrast to minimal activity in control regions.”

[Seiichi Mori @seiichi_mori]

A spatially resolved implantable microdevice for multiplexed in situ screening of engineered cellular therapies in solid tumors | Science Advances https://t.co/hQFLpqBzhc

[Seiichi Mori @seiichi_mori]

“we simultaneously delivered EGFR-targeting CAR-T cells and control T cells and analyzed adjacent tissues via IHC-based quantitative image analysis and multiplexed immunofluorescence.”

[Seiichi Mori @seiichi_mori]

“Ribonucleotide-enriched zones (REZs) cluster near transcription start sites (TSSs), coincide with C–phosphate–G (CpG) islands, R-loops, and G4 structures, and scale with gene expression.”

[Seiichi Mori @seiichi_mori]

Human nuclear ribomes reveal DNA-embedded ribonucleotides as epigenetic modulators of transcription-associated DNA supercoiling
https://t.co/jDCi013SJ5

[Seiichi Mori @seiichi_mori]

“We present high-resolution maps of ∼1 million rNMPs per genome across diverse human cells, revealing a non-random nuclear “ribome,” the genome-wide landscape of embedded rNMPs, enriched in GC-rich regions, regulatory elements, and telomeres.”

[Seiichi Mori @seiichi_mori]

Detection of “hidden” mitotic crossovers by long-read DNA sequencing
https://t.co/2QZnFvmdZ8