This is wild.
Claude just found something humans missed.
It spotted a hidden repeat pattern in raw bacteriophage DNA…
…and uncovered a previously unknown enzyme system in bacteriophages with CRISPR-like repeats. 🤯
950 agents. 21 hours. 210M tokens.
Let me explain what just happened.
Anthropic built a biology lab where Claude works alongside real scientists.
They told Claude to search a massive DNA database for interesting reverse transcriptases (enzymes that copy RNA into DNA). Then they let it run: ~950 Claude agents worked in parallel for 21 hours across 200,000+ enzymes.
One agent spotted a repeating DNA pattern next to an enzyme, the same kind of signature that originally led humans to discover CRISPR (the gene-editing tool that lets scientists precisely cut and edit DNA, now used in real medical treatments). It cross-checked the pattern against known systems, searched the literature, confirmed nobody had found it before, then wrote up a full scientific report like a human researcher would.
Anthropic scientists verified it in the lab. They named it ART. Its exact function is still unknown, but early signs suggest it may be programmable, similar to how CRISPR can be aimed at specific DNA.
Why it matters: finding tools like CRISPR used to take human experts months of manual searching. Here, AI did that work and found something real, at a speed no human team could match.
So don't misunderstand it as Claude curing cancer. Claude spotted something new in nature that humans missed.
Still crazy!
Jacob was a senior researcher who joined Anthropic in May. My Anthropic colleagues and I had been trying to recruit him for ~2 years, because we knew he was a strong researcher at OpenAI. Before he left, I pitched him to stay and join my team, and I was sad he decided to leave, as are many of my colleagues. 100% agree with him that AI poses serious risks to society, and I'm glad he's speaking out!
[Writing this in a personal capacity, not on behalf of my employer (Anthropic).]
Jacob’s thread is very worth reading. Here’s my birds-eye view of the situation with risks from AI:
1. AI developers believe their technology could cause human extinction (or similarly bad outcomes). This could happen in the next few years. In general, the more senior the employee, the more concerned they are.
2. Why do AI developers continue despite the risk? Due to a mixture of commercial incentives and a belief that they are in a race with other, less responsible AI developers that will abuse the technology or develop it less safely.
3. Unlike traditional software, we can’t “program” AIs to behave how we’d like. AIs frequently severely misbehave. For instance, AIs from multiple developers recently hacked their way out of secure evaluation environments and into real-world companies, even though no one asked them to do this.
4. We have methods that can nudge AIs towards better behavior, but nothing that can robustly align them. Insofar as there is a plan, it’s to make sure that AIs are good enough at alignment training that they can align their successors better than we can align current AIs.
5. Many AI developer staff desperately want to slow down to figure out how to build AI more safely. That was the intent of this open letter (which I signed): https://t.co/TZOm3LfptY
I work on safety research at Anthropic because I hope my work will reduce the chance of these extinction-level bad outcomes.
I resigned from Anthropic today. I spent the last three years doing pretraining research at both OpenAI and Anthropic. Neither company is acting responsibly. They are racing straight to self-improving superintelligence and gambling with our lives. More thoughts below.