Eivind Nyland

[Eivind Nyland @sernova]

@GreatStrides65 Also, the homozygous cohort result is additive on top of Symdeko (3-4% increase inFEV and a 10 decrease in mmol sweat chloride).

[Eivind Nyland @sernova]

@SymdekoT Tezacaftor (the other component in Symdeko) helps correct CFTR to enable it to reach the cell surface (which the DF508 mutation prevents). When at the cell surface, that protein acts like one with a gating defect (G551D) and Ivacaftor gets to do its thing.

[Marques Brownlee @MKBHD]

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