It does!! Not a randomized study .
Patients represent a real-world population treated at a single US medical center during the study. The median peak ALC was 3.2 × 103/μL. Across the full cohort, 16 patients (30.2%) developed peak ALC expansion >5 × 103/μL. For patients in the preintervention group (received cilta-cel between September 2023 and July 2024), 9 of 30 (30.0%) developed a peak ALC >5 × 103/μL; 5 of 9 (55.6%) experienced atypical neurologic events, and all 5 patients died of complications related to cilta-cel treatment. In the intervention group (patients who received cilta-cel between August 2024 and January 2025), 7 of 23 patients (30.4%) developed a peak ALC >5 × 103/μL, all of whom received ALC-directed dexamethasone prophylaxis. Only 1 of 7 of these patients experienced an atypical neurologic event, and the only death in this cohort was due to an infectious complication 9 months after CAR T-cell treatment.
https://t.co/B76wch69Sl
@RupClevelandCli@ASH_hematology I found ASH-SAP review for hematology very helpful and the ASH Hematology Review Series videos/ discussions were great.
Thanks @US_FDA for co-hosting the FDA-ASH Workshop! The past two days, participants explored the FDA’s role in #hematology product development through panels and case discussions, fostering dialogue on key regulatory issues.
https://t.co/pxS5dCV3uU
#HemeOnc@FDAOncology
It’s #ASHCRTI week in LaJolla.
@ASH_hematology
A week full of redoing study proposals, mentorship and forming life long professional friendships for participants and faculty - 28 trainees across classical and malignant hematology
#ASHTrainee
“Nonclassical” myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms represent a heterogeneous group of malignancies characterized by a wide range of clinical manifestations. https://t.co/7Xbu5haUbp #myeloidneoplasia#transplantation
#ASCO25 Looking forward to seeing CARTITUDE-1 long term presentation shortly! #mmsm
1 in 3 (32/97) patients alive and progression-free for ≥5 years - functional cure in my opinion.
Simultaneous JCO pub, highlighted NY Times
https://t.co/hNBVu0xx3a
https://t.co/2o2D9Ker1I
Dr. Punita Grover @UMNews showing ⬆️ chronic #GVHD with #PTCy/siro/MMF vs PTCy/tac/MMF in a sequential phase II well matched myeloablaive study setting ⚡️#Tandem25
@MediHumdani Agreed. Next step would be to understand the toxicities of PtCy and optimizing the dosage and regime ( as many groups are already trying to do)