As we use tools like #openevidence more, what are the guardrails against knowledge collapse? Is it all up to the user's volition, good habits? Can knowledge seeking be an addiction like doomscrolling?
@arjunmanrai And the fact that sometimes histories are not completely available or filled in from different sources over time. Physician interview skills have stenosed to accommodate the H/P template and not the iterative hypothesis testing an H/P is supposed to be
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The 3-dose regimen for late latent syphilis rests on remarkably thin evidence. The logic: organisms dividing more slowly in long-standing infection require prolonged treponemicidal penicillin levels โ hence weekly benzathine penicillin G (BPG) ร3.
Congratulations to Team India on a fantastic T20 World Cup win ๐ฎ๐ณ Tough luck today, New Zealand.
@Jaspritbumrah93, once again a match winner when it mattered most. @IamSanjuSamson, what a tournament and what an impact. Absolutely incredible.
Jeff Bezos's lifetime charitable giving: ~$4 billion, or about 2 months of his wealth's passive growth. Half a percent of his fortune would fund the Washington Post in perpetuity. Even Gilded Age plutocrats were far more generous. Where's a good robber baron when you need one?
โก๏ธPerhaps one dose is ok in older pts?๐ค
โก๏ธCan we do 2 doses instead of 3?
โก๏ธMore importantly, what is late latent syphilis in PLWHIV? Is it one year? 6 months? No prior titers? โก๏ธWith Benzathine penicillin shortages, I think this is not moot.
The 3-dose regimen for late latent syphilis rests on remarkably thin evidence. The logic: organisms dividing more slowly in long-standing infection require prolonged treponemicidal penicillin levels โ hence weekly benzathine penicillin G (BPG) ร3.
So what can we conclude?
โก๏ธThe 3-dose late latent syphilis regimen is built on an assumed treponemicidal level.
โก๏ธ There is no data about this dosing in the HIV era!! โก๏ธThere are differences in PCNG levels in young vs old populations. (PCN is renally excreted).