In one of the largest cohorts of patients with moderate/severe functional MR, including 14,004 adults from the National Echocardiographic Database of Australia (NEDA), AFMR and VFMR were classified based on LA and LV size and LVEF and were found in 40% (n = 5562) and 60% (n = 8442) of included patients, respectively.6 Prevalence of AFMR is often reported in AF and HFpEF
- RVEALとほとんど一緒の頻度
PRAISE-MR (NCT05991284) study, a multicentre, prospective, randomized trial, is ongoing to evaluate whether sacubitril-valsartan is beneficial in reducing MR severity in pa- tients with HFpEF and AFMR.51
- @Ph_Bertrand がやっている前向きRCT。非常に期待
DAPA-MODA trial52 showed that treatment with dapagliflozin significantly reduces LA vol- ume, irrespective of LVEF or diabetes status. A meta-analysis confirmed the association between SGLT2 inhibitors and im- proved LA volume index.53,5
- DAPA-MODA試験はあまり知りませんでした
Although dapagliflozin recently demonstrated to reduce MR severity among 104 patients with moderate or severe functional MR enrolled in the DEFORM trial, no specific details on AFMR were reported.57 In the EFFORT trial enrolling 128 patients with HF, LVEF ≥35% and <50%, and substantial functional MR (i.e., effective regurgitant orifice area >0.1 cm2), ertugliflozin significantly improved LV global longitudinal strain and LA remodelling, and reduced MR severity as compared with placebo.58 Of note, the mechanism of MR was VFMR in 80.5% and AFMR in 19.5% enrolled patients, and the benefit of ertugliflozin on the primary endpoint of change in effective regurgitant or- ifice area was consistent in both VFMR and AFMR subgroups (P-interaction = 0.827).58
- 思ったよりSGLT2iのFMRへのエビデンスは豊富である
In the Semaglutide Treat- ment Effect in People with Obesity and HFpEF (STEP-HFpEF) echocardiographic substudy,61 semaglutide attenuated LA re- modelling over 52 weeks, with a significant reduction in LA volume (estimated mean difference 6.13 mL; P = 0.0013). Furthermore, a meta-analysis showed that semaglutide reduced AF incidence by 30% compared with control therapies,indicating a potentially favourable effect on atrial electrical stability.62
- GLP-1 も左房への効果を期待
ELEVATE-AF (NCT06883864) is an ongoing multicentre, randomized trial to evaluate whether catheter ablation would significantly improve the severity of MR in patients with severe AFMR combined with persistent AF compared with drug therapy alone.
- アブレーションのRCTも進んでようです。Chinaの公的fundみたい。https://t.co/X9omYbQnFU
Could continuous positive airway pressure be the key to better heart health for high-risk sleep apnea patients? New multi-trial analysis shows promising cardiovascular benefits! Read more in #EHJ. https://t.co/pg1H9kFJIX
#cardiotwitter@ESC_Journals@escardio
Is transcatheter edge-to-edge repair the game changer for atrial functional mitral regurgitation? Read new insights from OCEAN-Mitral & REVEAL-AFMR registries show a crucial comparison with medical therapy in #EHJ.
https://t.co/lXsuLe8s4p
#cardiotwitter@ESC_Journals@escardio
Excellent work by Dr. Javed Butler and colleagues—new research in JACC: Advances presents an observational study comparing tirzepatide vs GLP-1RAs and their impact on cardiovascular outcomes.
https://t.co/lefmVtHbem
#cardiotwitter#heartfailure#hfc#clinicalresearch