We’re excited to welcome Steven Gossert , Ph.D. to SilcsBio as our new Applications Scientist -Computational Drug Design! 🎉
Steven has been using SILCS tech for years at BMS to accelerate biologics formulation and champion model-first drug development. 👏
One of his notable contributions? Co-authoring “Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational approaches” - a nice example of how modeling transforms formulation science. (https://t.co/0DmgiojGT5)
Using SILCS-Biologics, the GeneScience Pharmaceuticals team uncovered key protein-protein & protein-excipient interactions to design stable, ultra-high-concentration #antibody#formulations. 👏
Full paper 👉 https://t.co/KmmYsevnQZ
#SILCS#Biologics#mAbs#DrugDevelopment
Run CGenFF for Just $1 per Molecule (July Only)
Industry users can now generate topology and parameters for small molecules for just $1 each.
Explore #CGenFF with minimal commitment and maximum flexibility.
https://t.co/jrDZasf1JC
#CompChem#MolecularModeling
Beyond on overview of physics and ML-based methods applied to antibody-drug conjugates (ADCs) the paper presents calculations showing how MD simulations and the SILCS technology may be used to facilitate ADC development using utilities available from @silcsbio
New Perspective in Nature Chemical Biology: physics-based computational methods like MD and SILCS enable predictive, rapid design of ADCs—optimizing linker–site–DAR choices & payload–antibody interactions. #ADC#Biologics#CompChem#SILCS@alex_mackerell https://t.co/kVn6wizXmz
⚛️ CGenFF Web App (https://t.co/ecsmcyCqVL) has helped 10K+ users generate topology and parameters for 100K+ molecules.
Next week, a special opportunity is coming for industry users to try it with fewer barriers. 📅 Details drop July 1.
#CGenFF#CompChem#GROMACS#CHARMM
KRAS G12D: Once Undruggable, Now Predictable with SILCS
See how our platform delivers:
🔹 Binding site ID from apo structures
🔹 Accurate pose refinement + LGFE scoring
🔹 Atom-level SAR insights
#CompChem#DrugDesign#SILCS
https://t.co/1Xsl7wi3UB
ACS Spring 2025 is just two weeks away! The SilcsBio team will be in San Diego!
We’ll be at the ✅ Expo with a booth, plus we have a✅ talk and a ✅ poster session lined up. Stay tuned for details on our schedule.
If you’re attending, let’s connect! 👥 #CompChem#ACSSpring2025
SILCS v2025 Release Webinar Recording is Now Available! 🎬
Missed the live session? Catch up now to explore📺:
https://t.co/FfZCDfKjL6
📄 Read full release notes: https://t.co/pUXJHYtuDU
#CompChem#drugdesign
🎥 Missed the SILCS-WATER webinar? Watch the recording now!
Learn how SILCS-WATER provides exciting possibilities for understanding water's role in protein-ligand interactions.
📽️ https://t.co/WZvenIKwHD
Thanks to @anmol_aaryan and @alex_mackerell#CompChem#DrugDesign
🚀 Beta Testers Wanted for SILCS-Covalent!
We've developed a new covalent workflow module to enhance drug discovery. Check out our publication: https://t.co/rRDhsE0PX9.
Interested? Reach out at [email protected] for details and incentives!
Covalent drug design paper.
Reactive Site Detection: SILCS-Monte Carlo for accurate cysteine identification.
Warhead Optimization: ML models to rank warhead effectiveness.
Integrated Workflow: SILCS-Covalent for comprehensive insights.
https://t.co/fa4MY2h6YQ