SilcsBio

SilcsBio provides software and services for unlocking the full potential of computer-driven drug design.

[SilcsBio @silcsbio]

Learn more about Steven and his journey in our official announcement: 👉 https://t.co/rGMoGQBUcN

[SilcsBio @silcsbio]

We’re excited to welcome Steven Gossert , Ph.D. to SilcsBio as our new Applications Scientist -Computational Drug Design! 🎉
Steven has been using SILCS tech for years at BMS to accelerate biologics formulation and champion model-first drug development. 👏

[SilcsBio @silcsbio]

One of his notable contributions? Co-authoring “Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational approaches” - a nice example of how modeling transforms formulation science. (https://t.co/0DmgiojGT5)

[SilcsBio @silcsbio]

Using SILCS-Biologics, the GeneScience Pharmaceuticals team uncovered key protein-protein & protein-excipient interactions to design stable, ultra-high-concentration #antibody #formulations. 👏
Full paper 👉 https://t.co/KmmYsevnQZ
#SILCS #Biologics #mAbs #DrugDevelopment

[SilcsBio @silcsbio]

Run CGenFF for Just $1 per Molecule (July Only)

Industry users can now generate topology and parameters for small molecules for just $1 each.

Explore #CGenFF with minimal commitment and maximum flexibility.

https://t.co/jrDZasf1JC

#CompChem #MolecularModeling

[Machine Learning in Chemistry @ML_Chem]

Harnessing computational technologies to facilitate antibody–drug conjugate development #machinelearning #compchem https://t.co/571Ubm8gWh

[Alex MacKerell @alex_mackerell]

Beyond on overview of physics and ML-based methods applied to antibody-drug conjugates (ADCs) the paper presents calculations showing how MD simulations and the SILCS technology may be used to facilitate ADC development using utilities available from @silcsbio

[SilcsBio @silcsbio]

New Perspective in Nature Chemical Biology: physics-based computational methods like MD and SILCS enable predictive, rapid design of ADCs—optimizing linker–site–DAR choices & payload–antibody interactions. #ADC #Biologics #CompChem #SILCS @alex_mackerell https://t.co/kVn6wizXmz

[SilcsBio @silcsbio]

⚛️ CGenFF Web App (https://t.co/ecsmcyCqVL) has helped 10K+ users generate topology and parameters for 100K+ molecules.

Next week, a special opportunity is coming for industry users to try it with fewer barriers. 📅 Details drop July 1.

#CGenFF #CompChem #GROMACS #CHARMM

[SilcsBio @silcsbio]

KRAS G12D: Once Undruggable, Now Predictable with SILCS

See how our platform delivers:
🔹 Binding site ID from apo structures
🔹 Accurate pose refinement + LGFE scoring
🔹 Atom-level SAR insights

#CompChem #DrugDesign #SILCS

https://t.co/1Xsl7wi3UB

[SilcsBio @silcsbio]

SilcsBio Team will be at #ACSSpring2025

🎤 #Talk by @AsukaOrr : SILCS for ADC development
📅 Sun, Mar 23 | ⏰ 4:30 - 4:55 PM

📜 #Poster by @aakognole : Speed vs. Accuracy in CADD
📅 Tue, Mar 25 | ⏰ 7:00 - 9:00 PM |📌# 865

📍Booth at #ACSExpo # 3951

#CompChem #DrugDesign

[SilcsBio @silcsbio]

ACS Spring 2025 is just two weeks away! The SilcsBio team will be in San Diego!

We’ll be at the ✅ Expo with a booth, plus we have a✅ talk and a ✅ poster session lined up. Stay tuned for details on our schedule.

If you’re attending, let’s connect! 👥 #CompChem #ACSSpring2025

[SilcsBio @silcsbio]

SILCS v2025 Release Webinar Recording is Now Available! 🎬

Missed the live session? Catch up now to explore📺:
https://t.co/FfZCDfKjL6

📄 Read full release notes: https://t.co/pUXJHYtuDU

#CompChem #drugdesign

[SilcsBio @silcsbio]

Register here: https://t.co/KUA8kNqFVq

[SilcsBio @silcsbio]

Reminder to register! SILCS v2025 will be available starting next week. Join us to take an in-depth look.

[SilcsBio @silcsbio]

🌟 Join Us for the SILCS v2025 Release Webinar! 🌟

Key Highlights being coverd:
- Precise docking w/ water inclusion
- Improved ML-based hotspot ranking
- Streamlined multi-cofactor simulations

📅 Feb 13, 2025, 12 PM ET
Register: https://t.co/KUA8kNrdKY

#compchem #drugdesign

[SilcsBio @silcsbio]

🌟 Join Us for the SILCS v2025 Release Webinar! 🌟

Key Highlights being coverd:
- Precise docking w/ water inclusion
- Improved ML-based hotspot ranking
- Streamlined multi-cofactor simulations

📅 Feb 13, 2025, 12 PM ET
Register: https://t.co/KUA8kNrdKY

#compchem #drugdesign

[SilcsBio @silcsbio]

🎥 Missed the SILCS-WATER webinar? Watch the recording now!

Learn how SILCS-WATER provides exciting possibilities for understanding water's role in protein-ligand interactions.

📽️ https://t.co/WZvenIKwHD

Thanks to @anmol_aaryan and @alex_mackerell

#CompChem #DrugDesign

[SilcsBio @silcsbio]

🚀 Beta Testers Wanted for SILCS-Covalent!

We've developed a new covalent workflow module to enhance drug discovery. Check out our publication: https://t.co/rRDhsE0PX9.

Interested? Reach out at [email protected] for details and incentives!

[SilcsBio @silcsbio]

Covalent drug design paper.

Reactive Site Detection: SILCS-Monte Carlo for accurate cysteine identification.

Warhead Optimization: ML models to rank warhead effectiveness.

Integrated Workflow: SILCS-Covalent for comprehensive insights.

https://t.co/fa4MY2h6YQ

[SilcsBio @silcsbio]

SilcsBio 2024.2 Version is officially released.

Check out the new features here:

https://t.co/cdHU9JuYZQ