Simone_Cappelli

MD, Resident in Diabetes, Endocrinology and Metabolic Diseases in Pisa, focused on #MASLD, liver and lipidology.

Passionate in history, geopolitics, defence.

[Simone_Cappelli @SimoneCappelli6]

I use Twitter mostly for politic-related stuff, here are my works so far. (Nothing too impressive)

https://t.co/0g06FH61Ms

https://t.co/2EURSEynrm

https://t.co/WdNMkeC875

For now just sandy topics. 😳

[Antonio Di Siena @Antonio_DiSiena]

Quando un large host che gestisce più di trecento appartamenti sostiene apertamente e candidamente che gli studenti dovrebbero vivere in periferia perché il centro è economicamente destinato ad ospitare i B&B, succedono contemporaneamente due cose.
La prima è che emerge con estrema chiarezza come il modello di sviluppo basato su turismo e affitti brevi produca storture concrete e tangibili: opportunità e ricchezza per pochi, emarginazione e disagio per tanti.
La seconda, ancora più pericolosa, che definisce benissimo il concetto di cittadinanza all’interno della città turistica: il turista è infatti considerato il cittadino premium, il fruitore esclusivo di risorse e spazi urbani centrali. I secondi, ovvero tutti gli altri, invece, sono cittadini di serie D, una sorta di paria da emarginare perché incapaci di rispettare certi standard e di generare valore adeguato. Di fronte alla netta distinzione tra abitanti legittimi e illegittimi, su chi è prioritario e chi invece no, allora la domanda viene facile: quando politica ed enti locali (benché - a parole - si dicano timidamente pentiti fuori tempo massimo) sono parte attiva del processo di implementazione del modello di sviluppo turistico quale città e quale concetto di cittadinanza stanno concretamente contribuendo a plasmare? #Turistiacasanostra

[Naga Chalasani @nagachalasani]

It is of great interest to evaluate if PNPLA3 G-allele modifies response to MASH therapies. In our @HEP_Journal article, histological response to effruxifermin (FGF21 agonist) is PNPLA3 genotype agnostic. Await sema, tirza, and resmetirom data.

[Cheng Han Ng @ChengHanNg]

🧬 Excited to share our new review in npj Gut and Liver! We map the genetic, metabolic, histologic & environmental diversity of MASLD—and how this heterogeneity can shape precision-medicine strategies for risk stratification & targeted therapy. 🔗 https://t.co/kW9lyNHiG2

[Samuel Hume @DrSamuelBHume]

I count 12 abstracts on GLP1s for cancer prevention at ASCO

All of them are observational, and it's clear a proper randomized trial is needed here – two things on that

1. Lilly and Novo are not currently interested in doing it (thanks to @theglpman for helping to figure this out)

2. The first randomized trial is planned (called INSPIRE, from the ECOG-ACRIN research group) – for primary and secondary prevention of breast cancer in 11,000 overweight (non-obese) women, with a 5 year follow-up

[𝘽𝙡𝙖𝙠𝙚 @Arealmfngl]

If true this would be a huge win for feminism. Women are grossly underrepresented in the dictatorship and authoritarianism fields

[Hypertension @HyperAHA]

RESEARCH ARTICLE: Frailty Index Offers Greater Discrimination Than Age for Optimal Blood Pressure Targets: A Pooled Analysis of Two Randomized Trials

https://t.co/cZ8TDU0oif

[The Baveno Cooperation: an EASL Consortium @BavenoCoop]

🧫 New multisociety consensus on PSVD
🗣️ L. Elkrief | #EASLCongress
🔬 PSVD & NCPF now interchangeable
⚠️ Biopsy mandatory | can be diagnosed WITHOUT portal hypertension
💡 First globally endorsed framework (EASL/AASLD/APASL/ALEH)
🔗 https://t.co/aO1PaWIuN0

[Ryohei ONO, MD, PhD, FACC, FESC @ono_cardiology]

心不全におけるカリウムの至適範囲について #EHJ に掲載されました！

要点は、
👉3つの解析手法から至適範囲はK 4.2–5.0 mmol/L

👉HFrEFはreverse J-shaped、HFpEFはFlat U-shaped

👉従��のK<3.5 mmol/Lではなく、心不全ではK<4.0 mmol/Lを“低カリウム”と考えるべき可能性

https://t.co/i7JVZdxzRP

[CGH @AGA_CGH]

🌟Noninvasive scores (SAVE, ABC, LSPS, CHESS-ALARM) better predict decompensation in compensated advanced chronic liver disease than fibrosis models (MELD, ALBI, VITRO, FIB‑4) in practice.

🔗: https://t.co/TV2p5LnJtj

[Hypertension @HyperAHA]

RESEARCH ARTICLE: Sex-Specific Blood Pressure and Brain Microvascular Traits in a Model of Low-Renin Hypertension @SabharwalLab

https://t.co/GO5VoKPfMl

[Simone_Cappelli @SimoneCappelli6]

Is this a bad or a good thing?

[Eric Topol @EricTopol]

Here's all the published data on GLP-1 micro-dosing

[Hepatology Research @HepatolRes]

▶️Exploring a Subpopulation of MASLD Associated With New Onset of CKD Using Supervised Clustering Techniques

👉https://t.co/VsPUpcQK6R

#LiverX @WileyHealth

[Sophia Than @SophiaThan]

Carvedilol works better than propanolol in reduction of HVPG #EASL2026

[Melian Refugee @escapefrommelos]

>grants the love of the many
>teaches skill in the arts
>grants the power of similitude (changing ones appearance)

[S A I ™️ @WallStSai]

$AZN ASTRAZENECA’S MASH CANDIDATE AZD2693, A PNPLA3 ANTISENSE OLIGONUCLEOTIDE SHOWED NO IMPROVEMENT IN MASH RESOLUTION WITHOUT WORSENING OF FIBROSIS $IONS #MASH PH2 FAIL

$MDGL $NVO #MASH $XBI $VKTX

[Ahmed Bennis MD 🫀 @drbennisahmed]

Serum potassium as a modifier of MRA benefit — two trials, two drugs, consistent signal.

the therapeutic window for MRAs may be potassium-dependent. Optimising K⁺ — not just avoiding hyperkalaemia — could be integral to maximising benefit.

[Diabetologia @DiabetologiaJnl]

Low-dose anti-CD3 + GLP1-E2 combination therapy synergised to delay & reduce T1D in NOD mice 🐁Immunomodulation + beta cell resilience = a potent path towards durable efficacy 🔬https://t.co/wJKUfWfzAY 🔓 #T1D #CombinationTherapy #aCD3 #GLP1-E2

[Ahmed Bennis MD 🫀 @drbennisahmed]

New data from ORBITA: computed microvascular resistance (MVR) predicts who benefits from PCI.

Patients with HIGH MVR → attenuated benefit. Microvascular disease may be the reason PCI underperforms.

Bottom line: assess microvascular disease BEFORE stenting.

[Diabetes Care, an ADA research journal 🌟 @DiabetesCareADA]

Elevated ambient temperature significantly increases the short-term risk of hypoglycemia in adults with T1DM. #DCare #Article

Read here ➡️ https://t.co/iK4hRNdEFT

@AmDiabetesAssn @ADA_DiabetesPro @ADA_Pubs

[Eric Topol @EricTopol]

By connecting the brain and pancreas, activation of the vagus nerve increases insulin release after eating. But with obesity the opposite occurs!
Now we know why (NO-nitric oxide, Nos-nitric oxide synthase, KO-knockout). From experimental model work @scisignal
https://t.co/jvbJUxsIZX